Subcutaneous Dermoid Cysts

Brownstein, Martin H.

doi:10.1001/archderm.1973.01620170049013

Cited by 92 publications

(32 citation statements)

References 5 publications

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“…Cutaneous dermoid cysts result from the sequestration of cutaneous tissue along lines of embryonic fusion (1). DC in the periorbital area, midline of the neck, nasal root, forehead, mastoid area and the scalp have been reported (2).…”

Section: Introductionmentioning

confidence: 99%

Cutaneous dermoid cyst: Cytokeratin and filaggrin expression suggesting differentiation towards follicular infundibulum and mature sebaceous gland

Kurokawa

Nishimura²,

Hakamada³

et al. 2006

Oncol Rep

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Abstract. We experienced two cases of cutaneous dermoid cysts (DC). To elucidate the histogenesis of DC, we have studied cytokeratin (CK) expression in DC using ten different anti-keratin antibodies against CK1,7,8,10,14, 15, 16, 17, 18 and 19, antibody. In the cyst wall of DC, CK1 and 10 were expressed in suprabasal layer, and CK14 was limited to the basal layer. In sebaceous gland-like structures, CK14 was detected in sebaceous acinus, and CK17 was detected in sebaceous duct. The other CKs were not detected. Filaggrin was intensely detected in the granular layer in the cyst wall of DC. CK expression profile of DC was similar to follicular infundibulum and sebaceous gland. These results suggested that DC differentiates towards follicular infundibulum and mature sebaceous gland. IntroductionCutaneous dermoid cysts result from the sequestration of cutaneous tissue along lines of embryonic fusion (1). DC in the periorbital area, midline of the neck, nasal root, forehead, mastoid area and the scalp have been reported (2). DCs of the auricle are very rare (3). The histogenesis of DC still remains unclear.CK is an essential marker to evaluate the origin of epithelial tumors (4). Besides CK, filament aggregating protein (filaggrin), a histidine-rich phosphorylated basic protein of major constituents of keratohyaline granules, is a marker of terminal differentiation of epidermis (5). No immunohistochemical study of CK and filaggrin in DC has been reported.To elucidate the histogenesis of DC, we studied CK and filaggrin expression in DC using ten different anti-keratin antibodies against CK1,7,8,10,14, 15, 16, 17, 18 and 19, and anti-filaggrin antibody. Materials and methodsThe patient, a 48-year-old male had DC located on the left postauriclar area from at birth. The other patient, a 31-yearold female developed DC on the right postauriclar area ten years ago. The lesions were surgically excised. Each specimen was formalin-fixed, paraffin-embedded, stained with hematoxylin and eosin, and serially-cut sections were used for the immunohistochemical study. The anti-keratin antibodies used were as follows: 34ßB4 (CK1) (6), LHP1 (CK10) (7), LL002 (CK14) (7), LHK15 (CK15) (8), LL025 (CK16) (7), E3 (CK17) (7), 5D3 (CK18) (7) and b170 (CK19) (9) (all from Novocastra Laboratories Ltd., Newcastle-upon-Tyne, UK).The immunohistochemical study was carried out with the labeled streptoavidin-biotin method (LSAB, Dako, Carpenteria, CA, USA) was performed as previous study (10). Normal skin from the auricle served as controls. ResultsHematoxylin and eosin staining. Histopathological findings of the cases were similar. The cyst wall of DC was located in the deep dermis. Cyst wall was partly ruptured, resulting in the fibrosis with vellus hairs. The cyst wall was formed with keratinizing epithelium in granular layers. The keratinizing epithelium partly projected into the lumen-like crenulation. Thick laminated corneocytes were observed. In the vicinity of the cyst wall, sebaceous gland-like structure was observed (Fig. 1).Immunohistochem...

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Section: Introductionmentioning

confidence: 99%

Cutaneous dermoid cyst: Cytokeratin and filaggrin expression suggesting differentiation towards follicular infundibulum and mature sebaceous gland

Kurokawa

Nishimura²,

Hakamada³

et al. 2006

Oncol Rep

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“…Korisitoma tanım olarak bir organ ya da organın bir parçasına ait normal histolojik doku odağının olması gereken bölgeden başka bir bölgede bulunmasını ifade eder. Dermoid ve epidermoid kistler histopatolojik olarak korisitomaya da uyar ve orbita kavitesinde değişik lokalizasyonlarda saptanabilirler, ancak en sık saptanma yeri süperior ve temporal bölgedeki orbital kemiklerin sütürlerin komşuluğudur (3)(4)(5)(6). Dermoid ve epidermoid kistler gelişimsel olmakla birlikte doğumda saptanmazlar.…”

Section: Discussionunclassified

Orbital ve Paraorbital Dermoid-Epidermoid Kistlerin BT ve MRG Bulguları

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Erdoğan

Uğurlu

2012

Haseki

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ÖzetAmaç: Bu derlemede intra-orbital ve peri-orbital bölge yerleşimli histopatolojik olarak kanıtlanmış dermoid ve epidermoid kist olgularında radyolojik bulguların sunulması amaçlanmıştır. Yöntem: Ağustos 2010 -Mart 2012 tarihleri arasında orbita BT ve/veya MR inceleme uygulanmış orbital dermoid ve epidermoid kist tanısı alan 9 olgu değerlendirilmiştir. Radyolojik bulgular, literatür bulguları ışığında histopatolojik tanı bulguları ile birlikte değerlendirilmiştir. Bulgular: Hastaların 3'ü kadın, 6'sı erkekti. Yaş ortalamaları 19.3 yıl (13-29 yıl) idi. Tüm hastalara tedavi öncesi orbita MRG veya BT inceleme gerçekleştirildi. Lezyonlar yüzeyel yerleşimli ve derin yerleşimli şeklinde ikiye ayrıldı. Radyolojik bulgular lezyon yerleşimine göre değerlendirildi. Sonuç: Epidermoid ve dermoid kistler tüm orbital tümörlerin %3-9'unu oluşturan benign tümörlerdir. Bu tümörler sıklıkla orbita lateral duvar komşuluğunda yerleşirler, nadiren derin orbital kaviteye uzanım izlenebilir. Bu lezyonlar yavaş büyür ve nadiren komşu kemik yapılar ve sütürlerde erozyon oluşturur. Lezyonların radyolojik olarak tanınması ve olası komplikasyonların bilinmesi tanı ve takipte önemlidir. (Ha se ki T›p Bül te ni 2012; 50: 127-30) Anah tar Ke li me ler: Dermoid kist, orbital neoplazmlar, bilgisayarlı tomografi, manyetik rezonans görüntüleme Abs tractAim: The aim of this review was to present the radiological findings of patients with histopathologically proven dermoid and epidermoid cysts in periorbital and intraobital region. Methods: We evaluated 9 patients who underwent computed tomography (CT) or magnetic resonance imaging (MRI) of the orbit and were diagnosed with orbital dermoid and epidermoid cyts between August 2010 and March 2012. The radiological findings together with the histopathological findings were evaluated in light of the literature. Results: Three patients were women and 6 were men. The mean age of the subjects was 19.3 years (13-29 years). Before treatment, MRI or CT of the orbit was performed in all patients. The lesions were divided into two groups: superficially located and profoundly located. The radiological findings were evaluated according to the location of the lesions. Conclusion: Epidermoid and dermoid cysts are rare benign tumors, representing 3 to 9% of all orbital tumors. These tumors are most often located adjacent to the lateral orbital wall, and may rarely be found in deep orbital cavity. These lesions grow slowly and occasionally do erode adjacent bone and sutures. Radiological recognition of the lesions and to know possible complications are important in the diagnosis and follow-up. (The Me di cal Bul le tin of Ha se ki 2012; 50: 127-30)

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“…Congenital epidermoid cysts may result from failure of ectoderm to separate from underlying neural tube, or due to abnormal sequestration of surface ectoderm along the embryologic sites of dermal fusion along the eyes, ears, and face. 4,5 The acquired cysts, which are known as epidermal inclusion cysts, arise from inclusion of epidermal structures in the dermis and other deeper tissues after trauma. 2,3,6 The terms traumatic epidermoid cysts and EIC describe the same phenomenon, and both indicate a traumatic etiology.…”

Section: Discussionmentioning

confidence: 99%