Subcutaneous microchip-associated tumours in B6C3F1 mice: A retrospective study to attempt to determine their histogenesis

Calvez, Sophie Le; Perron-Lepage, Marie-France; Burnett, Roger M.

doi:10.1016/j.etp.2005.10.007

Cited by 37 publications

(39 citation statements)

References 18 publications

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“…These include migration, infection, neoplastic growth reaction, failure to work or loss from the body (Rao & Edmonson 1990, Burk & Eich 1995, Swift 2000, Elcock et al 2001, Swift 2002, Le Calvez et al 2006, Vascellari et al 2006. To minimize the risk of adverse reactions in the fetus, it is important to follow the manufacturers' instructions and to fix the animal so the thigh muscle is accessible without harming the fetus.…”

Section: Discussionmentioning

confidence: 99%

“…The microchip is hermetically encapsulated within a smooth and strong biocompatible glass and is small enough to fit into a 12G hypodermic needle. The capsule is about the size of a grain of rice (12 mm long and 2 mm in diameter) and a 5 mm long part of the body is covered by a porous polypropylene polymer sheath as an antimigration measure (Rao & Edmondson 1990, Ball et al 1991, Elcock et al 2001, Le Calvez et al 2006. This polypropylene cap causes development of a thin coherent membrane consisting of fibrocytes and collagen fibres thereby fixing the microchip (Rao & Edmondson 1990).…”

mentioning

confidence: 99%

“…This polypropylene cap causes development of a thin coherent membrane consisting of fibrocytes and collagen fibres thereby fixing the microchip (Rao & Edmondson 1990). Compared with other conventional means, such as ear notches, tags, toe-clips or tattoos which can be lost, may be painful or become difficult to see, the implantable microchip device is recommended as a fast and secure way of identifying animals (Le Calvez et al 2006).…”

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confidence: 99%

“…Implantable microchips were introduced in the late 1980s and have since then been routinely used in companion animals, production animals, laboratory animals, etc. for secure, permanent and unique identification of individual animals (Rao & Edmonson 1990, Ball et al 1991, Murasugi et al 2003, Le Calvez et al 2006). The system is based on the radiofrequency identification technology and does not use batteries.…”

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A novel method for transuterine identification of piglets

Birck¹,

Iburg²,

Schmidt³

et al. 2008

Lab Anim

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SummaryImplantable microchips provide a secure, permanent and unique identification of individual animals. When performing fetal intervention studies in experimental animal models easy and secure identification of fetuses is desirable, as having test and control groups within the same uterus reduces the total number of animals used in a study. The aims of this study were: (1) to establish a protocol to identify porcine fetuses in utero by microchip implantation and (2) to assess postnatally whether clinical or pathological reactions to the implant occurred. Two Danish Landrace/Danish Large White crossbred sows at day 100 of gestation were used. The sows were sedated with azaperone and induced with propofol intravenously. Anaesthesia was maintained with isoflurane and oxygen. Antibiotics were administered intramuscularly (i.m.) at induction and analgesia was given pre-, intra-and postoperatively. A laparotomy was performed and the uterus exteriorized. The rump of the first fetus was recognized through the uterine wall and the thigh muscle of the fetus was fixed between the thumb and the forefinger. The microchip was then implanted into the fetus at an angle of 458 i.m. in the lateral hindleg using an insertion device with a 12G needle. The same procedure was done in every fetus. The uterus was returned to the abdomen and the abdominal wall closed. The sows gave birth to 24 liveborn piglets and one stillborn. None of the liveborn piglets were limping at the time of birth and no visible cutaneous or palpable reactions on the hindlegs were observed. Following euthanasia, the microchip was easily localized and no macroscopic reactions at the implantation site were seen. None of the piglets had more than one microchip implanted. Histology showed a chronic mild foreign body granulomatous inflammatory response with peripheral eosinophils surrounding the microchip. No inflammation was evident in the adjacent muscles. It is concluded that transuterine identification of piglets two weeks before delivery is feasible using a microchip implant as an effective, easy and reliable method for identification of individuals after birth.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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A novel method for transuterine identification of piglets

Birck¹,

Iburg²,

Schmidt³

et al. 2008

Lab Anim

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“…In a fibrosarcoma found at the site of a microchip implant in a dog, the authors describe that the microchip was attached to the mass and there was multifocal random necrosis and peripheral lymphoid aggregates of a T cell phenotype (Vascellari et al 2006). In a report of subcutaneous microchip-associated tumors in 52 B6C3F1 mice, all masses contained the microchip or were adjacent to it and there was a vestigial fibrous capsule and/or a focus of necrosis associated with the microchip (Le Calvez et al 2006). In this study, there were multinucleated giant cells in some tumors and areas of hemorrhage and necrosis with variable amounts of inflammation commonly seen in the larger tumors.…”

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Role of inflammation/wound healing in feline oncogenesis: A commentary

Kidney

2008

Journal of Feline Medicine and Surgery

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Mouse Breeding and Colony Management

2011

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The possibility to genetically modify the mouse genome has enabled the creation of numerous lines of genetically engineered mouse models (GEMMs). As a result, the demand for housing space in research facilities is increasing. Knowledge of the basis of mouse reproduction and of the methods to handle colonies of GEMMs is therefore mandatory to efficiently populate facilities. The mouse has a short generation period, produces large progenies, and can breed all year round. However, environmental parameters (bedding, diet, cage type, temperature, hygrometry, light, noise, and sanitary status) strongly influence the breeding efficiency and experimental data, and must be tightly controlled. Efficient GEMM colony management requires adequate recording of breeding and proper identification and genotyping of animals. Various mating types and breeding schemes can be used, depending on the type of studies conducted. The recent development of assisted reproduction methods helps circumvent some of the issues faced with those lines especially difficult to breed. Curr. Protoc. Mouse Biol. 1:239-264. © 2011 by John Wiley & Sons, Inc.

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Subcutaneous microchip-associated tumours in B6C3F1 mice: A retrospective study to attempt to determine their histogenesis

Cited by 37 publications

References 18 publications

A novel method for transuterine identification of piglets

A novel method for transuterine identification of piglets

Role of inflammation/wound healing in feline oncogenesis: A commentary

Mouse Breeding and Colony Management

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