Subgrouping school-aged children on the autism spectrum based on co-occurring psychiatric symptoms

Piergies, Antonia M.H.; Hirota, Tomoya; Monden, Rei; Zheng, Shuting

doi:10.1016/j.rasd.2022.101983

Cited by 6 publications

(3 citation statements)

References 127 publications

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“…In part due to this extensive phenotype variability, autism diagnosis in humans is a lengthy process that encompasses direct observation of the individuals, which can be extended with neuropsychological evaluation tests, and interviews with parents or caregivers 11,12 . Therefore, there have recently been considerable scientific efforts to identify distinct subgroups within the spectrum of autism 13–15 .…”

Section: Introductionmentioning

confidence: 99%

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Multi-parametric assays capture sex- and environment-dependent modifiers of behavioral phenotypes in autism mouse models

Wahl,

Karim,

Hassett

et al. 2024

Preprint

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Current phenotyping approaches for murine autism models often focus on one selected behavioral feature, making the translation onto a spectrum of autistic characteristics in humans challenging. Furthermore, sex and environmental factors are rarely considered. Here, we aimed to capture the full spectrum of behavioral manifestations in three autism mouse models to develop a "behavioral fingerprint" that takes environmental and sex influences under consideration. To this end, we employed a wide range of classical standardized behavioral tests; and two multi-parametric behavioral assays: the Live Mouse Tracker and Motion Sequencing (MoSeq), on male and femaleShank2,Tsc1and Purkinje cell specific-Tsc1mutant mice raised in standard or enriched environments. Our aim was to integrate our high dimensional data into one single platform to classify differences in all experimental groups along dimensions with maximum discriminative power. Multi-parametric behavioral assays enabled far more accurate classification of experimental groups compared to classical tests, and dimensionality reduction analysis demonstrated significant additional gains in classification accuracy, highlighting the presence of sex, environmental and genotype differences in our experimental groups. Together, our results provide a complete phenotypic description of all tested groups, suggesting multi-parametric assays can capture the entire spectrum of the heterogenous phenotype in autism mouse models.

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Section: Introductionmentioning

confidence: 99%

“…Therefore, there have recently been considerable scientific efforts to identify distinct subgroups within the spectrum of autism [13][14][15] .…”

Section: Introductionmentioning

confidence: 99%

Multi-parametric assays capture sex- and environment-dependent modifiers of behavioral phenotypes in autism mouse models

Wahl,

Karim,

Hassett

et al. 2024

Preprint

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“…many other psychiatric disorders, neurologic and other non-psychiatric medical disorders must be considered (M. Gupta et al, n.d.), These may be more common in individuals with non-verbal IQs < 70 and atypical sleep duration(Piergies et al, 2022) …”

mentioning

confidence: 99%

Autism and Suicide: Strategies to Dovetail Emerging Evidence in Child and Adolescent Suicide Risk Assessments

Gupta,

Petti

2023

Preprint

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Background: This narrative review provides readers with a greater awareness of the increasing prevalence of diagnosed autism spectrum disorder (ASD) in psychiatric clinical settings and the high risk that ASD and autistic traits in the population place the affected individuals at heightened risk for suicidality and suicide. Methods: It represents a comprehensive, systematic literature review. supplemented with reverse citations to assure updated information. By title and abstract 456 articles were identified 456 and 71 articles met the inclusion criteria. Out of those, 50 articles were used for initial review and 15 were added later, manually or through reverse citations. Results: Results indicate that associated suicidal thoughts and behaviors (STB) with ASD, many concomitants comorbid mental health conditions ASD, and suicide risk factors that overlap with ASD symptoms are not clearly understood. Higher rates of STB and suicide have been identified across the age spectrum with ASD/high autistic traits compared to those from the general population in age/sex-matched comparison groups. Increased risk of STB in higher functioning ASD is emphasized. Interpersonal conflict and depression are significant risk factors as are comorbid borderline personality, bipolar disorder, anxiety, and obsessive-compulsive disorders. Conclusions: Multiple diagnostic challenges are considered that support the need for more focused research in this area, better, more ASD-related screening instruments that address the unique features of ASD-related psychopathology, and improved training for clinicians in screening and preventive efforts for enhanced competence and greater comfort in dealing with STB in those with autistic traits and ASD.

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Brief Report: Psychometric Properties of the Brief Problem Monitor-Parent (BPM-P) 6–18 in a Sample of Children Referred to an Autism Specialty Clinic

Lampinen,

Zheng,

Olson

et al. 2024

J Autism Dev Disord

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Subgrouping school-aged children on the autism spectrum based on co-occurring psychiatric symptoms

Cited by 6 publications

References 127 publications

Multi-parametric assays capture sex- and environment-dependent modifiers of behavioral phenotypes in autism mouse models

Multi-parametric assays capture sex- and environment-dependent modifiers of behavioral phenotypes in autism mouse models

Autism and Suicide: Strategies to Dovetail Emerging Evidence in Child and Adolescent Suicide Risk Assessments

Brief Report: Psychometric Properties of the Brief Problem Monitor-Parent (BPM-P) 6–18 in a Sample of Children Referred to an Autism Specialty Clinic

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