Subiculum–BNST structural connectivity in humans and macaques

Berry, Samuel C; Lawrence, Andrew D.; Lancaster, Thomas M.; Casella, Chiara; Aggleton, John P.; Postans, Mark

doi:10.1016/j.neuroimage.2022.119096

Cited by 3 publications

(2 citation statements)

References 137 publications

(271 reference statements)

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“…The results of the current study showed that retro‐labelled input neurons in the HIP were primarily located in the pyramidal layers of the CA1 and SUB. In prior studies, the vSUB→BNST→VTA pathway has been suggested as a flow that integrates learning‐associated information with reward or motivation (Berry et al, 2022; Jalabert et al, 2009). Our data suggest that BNST CR‐expressing neurons may be hubs in this pathway.…”

Section: Discussionmentioning

confidence: 99%

Whole‐brain connectivity to the bed nucleus of the stria terminalis calretinin‐expressing interneurons in male mice

Zhu,

Tao,

Huang

et al. 2023

Eur J of Neuroscience

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The bed nucleus of the stria terminalis (BNST) is a neuropeptide‐enriched brain region that modulates a wide variety of emotional behaviours and states, including stress, anxiety, reward and social interaction. The BNST consists of diverse subregions and neuronal ensembles; however, because of the high molecular heterogeneity within BNST neurons, the mechanisms through which the BNST regulates distinct emotional behaviours remain largely unclear. Prior studies have identified BNST calretinin (CR)‐expressing neurons, which lack neuropeptides. Here, employing virus‐based cell‐type‐specific retrograde and anterograde tracing systems, we mapped the whole‐brain monosynaptic inputs and axonal projections of BNST CR‐expressing neurons in male mice. We found that BNST CR‐expressing neurons received inputs mainly from the amygdalopiriform transition area, central amygdala and hippocampus and moderately from the medial preoptic area, basolateral amygdala, paraventricular thalamus and lateral hypothalamus. Within the BNST, plenty of input neurons were primarily located in the oval and interfascicular subregions. Furthermore, numerous BNST CR‐expressing neuronal boutons were observed within the BNST but not in other brain regions, thus suggesting that these neurons are a type of interneuron. These results will help further elucidate the neuronal circuits underlying the elaborate and distinct functions of the BNST.

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Section: Discussionmentioning

confidence: 99%

Whole‐brain connectivity to the bed nucleus of the stria terminalis calretinin‐expressing interneurons in male mice

Zhu,

Tao,

Huang

et al. 2023

Eur J of Neuroscience

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“…Apart from its role in episodic memory and spatial navigation ( Poppenk et al, 2013 ), the subiculum as one of the main output regions of the hippocampus has been shown to play an important role in regulating the HPA-axis. This regulation is mediated almost exclusively via the BNST as a relay center and this connection was first described in rodents ( Cullinan et al, 1993 ; Dong et al, 2001a ), but has since also been reported in both humans and non-human primates ( Berry et al, 2022 ).…”

Section: Anatomy and Functional Connectivity In The Bnstmentioning

confidence: 90%

The neurophysiological basis of stress and anxiety - comparing neuronal diversity in the bed nucleus of the stria terminalis (BNST) across species

van de Poll,

Cras,

Ellender

2023

Front. Cell. Neurosci.

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The bed nucleus of the stria terminalis (BNST), as part of the extended amygdala, has become a region of increasing interest regarding its role in numerous human stress-related psychiatric diseases, including post-traumatic stress disorder and generalized anxiety disorder amongst others. The BNST is a sexually dimorphic and highly complex structure as already evident by its anatomy consisting of 11 to 18 distinct sub-nuclei in rodents. Located in the ventral forebrain, the BNST is anatomically and functionally connected to many other limbic structures, including the amygdala, hypothalamic nuclei, basal ganglia, and hippocampus. Given this extensive connectivity, the BNST is thought to play a central and critical role in the integration of information on hedonic-valence, mood, arousal states, processing emotional information, and in general shape motivated and stress/anxiety-related behavior. Regarding its role in regulating stress and anxiety behavior the anterolateral group of the BNST (BNSTALG) has been extensively studied and contains a wide variety of neurons that differ in their electrophysiological properties, morphology, spatial organization, neuropeptidergic content and input and output synaptic organization which shape their activity and function. In addition to this great diversity, further species-specific differences are evident on multiple levels. For example, classic studies performed in adult rat brain identified three distinct neuron types (Type I-III) based on their electrophysiological properties and ion channel expression. Whilst similar neurons have been identified in other animal species, such as mice and non-human primates such as macaques, cross-species comparisons have revealed intriguing differences such as their comparative prevalence in the BNSTALG as well as their electrophysiological and morphological properties, amongst other differences. Given this tremendous complexity on multiple levels, the comprehensive elucidation of the BNSTALG circuitry and its role in regulating stress/anxiety-related behavior is a major challenge. In the present Review we bring together and highlight the key differences in BNSTALG structure, functional connectivity, the electrophysiological and morphological properties, and neuropeptidergic profiles of BNSTALG neurons between species with the aim to facilitate future studies of this important nucleus in relation to human disease.

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Human BNST volume is not simply sexually dimorphic

Berry,

Suri,

Lisi

et al. 2024

Preprint

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"The bed nucleus of the stria terminalis (BNST) is a sexually dimorphic basal forebrain region", is a claim prevalent across rodent and human neuroscience research, with particular emphasis on its substantially larger size in males. Despite the pervasiveness of this claim, with potential implications for understanding sex differences in anxiety and substance use disorders, inspection of prior literature reveals a complex and nuanced picture. Direct evidence for larger male BNST size in humans comes solely from a handful of mostly small-scale post-mortem studies, which show either no, moderate, or very large differences, therefore indicating the need for a larger systematic investigation. Addressing this, we developed a novel 3T T1-weighted (T1w) manual segmentation protocol of the BNST, which was applied to T1w structural MRI data in 170 young human adults. Using a Bayesian modelling approach, taking into account existing post-mortem data, and controlling for total brain volume, age, and sibship, we find little evidence for total BNST volume differences between males and females. We recommend that researchers exercise caution when reporting evidence of BNST sexual dimorphism, particularly when translating findings from rodent models in which the BNST may play a different, olfaction-focused, role.

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Subiculum–BNST structural connectivity in humans and macaques

Cited by 3 publications

References 137 publications

Whole‐brain connectivity to the bed nucleus of the stria terminalis calretinin‐expressing interneurons in male mice

Whole‐brain connectivity to the bed nucleus of the stria terminalis calretinin‐expressing interneurons in male mice

The neurophysiological basis of stress and anxiety - comparing neuronal diversity in the bed nucleus of the stria terminalis (BNST) across species

Human BNST volume is not simply sexually dimorphic

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