Subjective, cognitive/psychomotor, and physiological effects of aripiprazole in Chinese light and heavy smokers

Yu, Long-Chuan; Sun, Hongqiang; Bao, Yanping; Li, Suxia; Beveridge, Thomas J.R.; Di, Xiaolan; Yang, Fude; Lü, Lin

doi:10.1016/j.drugalcdep.2008.10.024

Cited by 19 publications

(24 citation statements)

References 89 publications

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“…A forward and a backward condition were used. Participants earned one point for each correctly repeated set (Liu et al, 2009;Lynn and Dai, 1993;Wechsler et al, 2002).…”

Section: Task Batterymentioning

confidence: 99%

Stress Enhances Retrieval of Drug-Related Memories in Abstinent Heroin Addicts

Zhao

Shi

Zhang

et al. 2009

Neuropsychopharmacol

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Stress is associated with relapse to drugs after abstinence, but the mechanisms for this association are unclear. One mechanism may be that stress enhances abstinent addicts' recall of memories of drugs as stress relievers. This study assessed the effects of stress on free recall and cued recall of 10 heroin-related and 10 neutral words learned 24 h earlier by 102 abstinent heroin addicts. These participants were randomly assigned to three experiments that also assessed attention and working memory. Experiment 1 used a psychosocial stressor (Trier social stress test (TSST)) before testing for recall of heroin-related words. Experiment 2 added administration of the b-adrenoceptor antagonist propranolol 1 h before the psychosocial stressor. Experiment 3 added administration of either cortisol with propranolol, cortisol alone, or propranolol alone 1 h before word recall to determine whether stress enhancement of heroin-related word recall required noradrenergic-glucocorticoid interactions. We found that free recall of heroin-related words in abstinent addicts was enhanced after stress or cortisol administration when compared with a non-stress condition or placebo, respectively, whereas these interventions had no effect on neutral word recall. b-adrenergic blockade blocked the enhancing effect of stress or cortisol on free recall of heroin-related words. Neither stress nor cortisol affected cued recall, attention, or working memory. The potential of b-adrenergic blockade to reduce or block stress-induced enhancement of drug-related memory retrieval may be relevant to preventing stress-induced relapse in abstinent heroin addicts.

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“…A forward and a backward condition were used. Participants earned one point for each correctly repeated set (Liu et al, 2009;Lynn and Dai, 1993;Wechsler et al, 2002).…”

Section: Task Batterymentioning

confidence: 99%

Stress Enhances Retrieval of Drug-Related Memories in Abstinent Heroin Addicts

Zhao

Shi

Zhang

et al. 2009

Neuropsychopharmacol

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“…44 Finally, neither 5 nor 10 mg of aripiprazole resulted in working memory or attention/psychomotor deficits in participants. 44 However, in this previous study, aripiprazole was immediately administered, and only male smokers were recruited. To further characterize the therapeutic effects of aripiprazole for smoking cessation, the present study investigated whether 2-week treatment with 10-mg aripiprazole could affect smoking urge, nicotine withdrawal symptoms, and the subjective response to the first cigarette in Chinese male and female heavy smokers.…”

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confidence: 92%

“…44 Immediate administration of 10-mg aripiprazole significantly decreased the subjective response to a smoked cigarette and attenuated drug cue-induced urges to smoke. 44 Furthermore, the attenuating effects of 10-mg aripiprazole were most prominent in heavy smokers treated. 44 Finally, neither 5 nor 10 mg of aripiprazole resulted in working memory or attention/psychomotor deficits in participants.…”

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confidence: 96%

“…44 Furthermore, the attenuating effects of 10-mg aripiprazole were most prominent in heavy smokers treated. 44 Finally, neither 5 nor 10 mg of aripiprazole resulted in working memory or attention/psychomotor deficits in participants. 44 However, in this previous study, aripiprazole was immediately administered, and only male smokers were recruited.…”

mentioning

confidence: 97%

“…However, a recent multicenter doubleblind study found that alcohol-dependent patients treated with aripiprazole dropped out of the trial at higher rates than patients receiving placebo, possibly due to dose-related aversive effects. 43 In contrast to these inconclusive results from alcohol studies, the safety and the efficacy of aripiprazole have been demonstrated in a number of clinical studies of other drugs of abuse, including nicotine, 44 amphetamine, 45Y48 cocaine, 49 and ephedrine. 50 Notably, most of the clinical studies mentioned previously enrolled a limited number of participants and involved short-term aripiprazole administration.…”

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confidence: 99%

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Long-Term Treatment With Aripiprazole on the Waking and Postprandial Urges to Smoke in Chinese Heavy Smokers

Liu

Bao²,

Sun³

et al. 2010

Journal of Clinical Psychopharmacology

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The central dopaminergic system plays a critical role in the reinforcing effects of nicotine, which are key determinants in the urge to smoke. Previous study has demonstrated that immediate administration of 10-mg aripiprazole significantly decreased various subjective responses to smoking. The present study investigated whether 2-week treatment with 10-mg aripiprazole could attenuate waking and postprandial urges to smoke in Chinese male and female heavy smokers. A randomized and placebo-controlled pilot clinical study was conducted to assess the effect of aripiprazole on various responses to smoking. The primary outcomes were subject's ratings on questionnaires of smoking urge, withdrawal syndromes, and cigarette evaluation. All participants were administered either placebo or 10-mg aripiprazole for 2 weeks. Throughout the experiment, participants were required to self-report (1) smoking urge and nicotine withdrawal symptoms before their first cigarette after awakening and after lunch and (2) subjective responses to the first cigarette smoked of the day and after lunch. Aripiprazole was associated with significantly decreased waking and postprandial urges to smoke. Aripiprazole failed to produce a significant effect on overall nicotine withdrawal symptoms after awakening and after lunch. However, waking, but not postprandial, withdrawal craving and syndromes were significantly reduced by aripiprazole. Aripiprazole had no effect on the overall subjective responses to the first cigarette of the day and after lunch. The attenuating effects of aripiprazole on waking and postprandial urges to smoke demonstrate the promising effect of aripiprazole in the treatment of nicotine dependence.

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Effects of aripiprazole and haloperidol on neural activation during a simple motor task in healthy individuals: A functional MRI study

Goozée

O’Daly

Handley

et al. 2016

Human Brain Mapping

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The dopaminergic system plays a key role in motor function and motor abnormalities have been shown to be a specific feature of psychosis. Due to their dopaminergic action, antipsychotic drugs may be expected to modulate motor function, but the precise effects of these drugs on motor function remain unclear. We carried out a within-subject, double-blind, randomized study of the effects of aripiprazole, haloperidol and placebo on motor function in 20 healthy men. For each condition, motor performance on an auditory-paced task was investigated. We entered maps of neural activation into a random effects general linear regression model to investigate motor function main effects. Whole-brain imaging revealed a significant treatment effect in a distributed network encompassing posterior orbitofrontal/anterior insula cortices, the inferior temporal, and postcentral gyri. Post-hoc comparison of treatments showed neural activation after aripiprazole did not differ significantly from placebo in either voxel-wise or region of interest analyses, with the results above driven primarily by haloperidol. We also observed a simple main effect of haloperidol compared with placebo, with increased task-related recruitment of posterior cingulate and precentral gyri.Furthermore, region of interest analyses revealed greater activation following haloperidol compared with placebo in the precentral and post-central gyri, and the putamen. These diverse modifications in cortical motor activation may relate to the different pharmacological profiles of haloperidol and aripiprazole, although the specific mechanisms underlying these differences remain unclear. Evaluating healthy individuals can allow investigation of the effects of different antipsychotics on cortical activation, independently of either disease-related pathology or previous treatment.

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Subjective, cognitive/psychomotor, and physiological effects of aripiprazole in Chinese light and heavy smokers

Cited by 19 publications

References 89 publications

Stress Enhances Retrieval of Drug-Related Memories in Abstinent Heroin Addicts

Stress Enhances Retrieval of Drug-Related Memories in Abstinent Heroin Addicts

Long-Term Treatment With Aripiprazole on the Waking and Postprandial Urges to Smoke in Chinese Heavy Smokers

Effects of aripiprazole and haloperidol on neural activation during a simple motor task in healthy individuals: A functional MRI study

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