Sublobar resection versus lobectomy for stage IA non-small-cell lung cancer ≤ 2 cm: a systematic review and patient-level meta-analysis

Fong, Khi Yung; Chan, Yiong Huak; Chia, Cynthia Ming Li; Agasthian, Thirugnanam; Lee, Pyng

doi:10.1007/s13304-023-01627-z

Cited by 5 publications

(4 citation statements)

References 57 publications

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“…A recent meta-analysis of randomized clinical trials comparing sublobar to lobar resection in stage IA NSCLC showed sublobar resection and lobectomy to have similar OS, DFS, and disease recurrence rates for stage IA NSCLC [ 39 ]. Another meta-analysis by Fong et al also revealed similar outcomes, adding that sublobar resection ensures safer future treatments for patients experiencing recurrence or a second primary tumor [ 40 ]. A cross-sectional study by Brunelli et al discussed dyspnea after segmentectomy versus lobectomy, comparing their Dyspnea Index Score.…”

Section: Discussionmentioning

confidence: 95%

“…The GGO group also had a superior 5-year DFS [ 51 ]. Hence, while some studies found no association between CTR and tumor prognosis [ 52 , 53 ], the majority suggested the utilization of CTR to assess the T stage [ 40 , 45 , 54 ]. This prognosis may also differ based on the histologic characteristics of SSNs ( Table 1 ) [ 40 , 55 ].…”

Section: Discussionmentioning

confidence: 99%

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Recent Advancements in Minimally Invasive Surgery for Early Stage Non-Small Cell Lung Cancer: A Narrative Review

Khan,

Albalkhi,

Garatli

et al. 2024

JCM

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Introduction: Lung cancer remains a global health concern, with non-small cell lung cancer (NSCLC) comprising the majority of cases. Early detection of lung cancer has led to an increased number of cases identified in the earlier stages of NSCLC. This required the revaluation of the NSCLC treatment approaches for early stage NSCLC. Methods: We conducted a comprehensive search using multiple databases to identify relevant studies on treatment modalities for early stage NSCLC. Inclusion criteria prioritized, but were not limited to, clinical trials and meta-analyses on surgical approaches to early stage NSCLC conducted from 2021 onwards. Discussion: Minimally invasive approaches, such as VATS and RATS, along with lung resection techniques, including sublobar resection, have emerged as treatments for early stage NSCLC. Ground-glass opacities (GGOs) have shown prognostic significance, especially when analyzing the consolidation/tumor ratio (CTR). There have also been updates on managing GGOs, including the non-surgical approaches, the extent of lung resection indicated, and the level of lymphadenectomy required. Conclusions: The management of early stage NSCLC requires a further assessment of treatment strategies. This includes understanding the required extent of surgical resection, interpreting the significance of GGOs (specifically GGOs with a high CTR), and evaluating the efficacy of alternative therapies. Customized treatment involving surgical and non-surgical interventions is essential for advancing patient care.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Recent Advancements in Minimally Invasive Surgery for Early Stage Non-Small Cell Lung Cancer: A Narrative Review

Khan,

Albalkhi,

Garatli

et al. 2024

JCM

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show abstract

“…A recent meta-analysis of randomized clinical trials comparing sublobar to lobar resection in stage IA NSCLC showed sublobar resection and lobectomy to have similar OS, DFS, and disease recurrence rates for stage IA NSCLC [37]. Another meta-analysis by Fong et al also revealed similar outcomes, adding that sublobar resection ensures safer future treatments for patients experiencing recurrence or a second primary tumor [38].…”

Section: Is Sublobar Resection Superior To Lobectomy For Stage Ia Nsc...mentioning

confidence: 97%

Recent Advancements in Minimally Invasive Surgery for Early-Stage Non-Small Cell Lung Cancer: A Narrative Review

Ibrar,

Albalkhi,

Garatli

et al. 2024

Preprint

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Introduction: Lung cancer remains a global health concern, with non-small cell lung cancer (NSCLC) comprising the majority of cases. Early detection of lung cancer has led to an increased number of cases identified in the earlier stages of NSCLC. This required the revaluation of the NSCLC treatment approaches for early-stage NSCLC. Methods: We conducted a comprehensive search using multiple databases to identify relevant studies on treatment modalities for early-stage NSCLC. Inclusion criteria prioritized but were not limited to, clinical trials and meta-analyses on surgical approaches to early-stage NSCLC conducted from 2021 onwards. Discussion: Minimally invasive approaches, such as VATS and RATS, along with lung resection techniques, including sublobar resection have emerged as treatments for early-stage NSCLC. Ground-glass opacities (GGOs) hve shown prognostic significance, especially when analyzing the consolidation-tumor ratio (CTR). There have also been updates on managing GGOs, including the non-surgical approaches, the extent of lung resection indicated, and the level of lymphadenectomy required. Conclusion: The management of early-stage NSCLC requires further assessment of treatment strategies. This includes understanding the required extent of surgical resection, interpreting the significance of GGOs (specifically GGOs with a high CTR), and evaluating the efficacy of alternative therapies. Customized treatment involving surgical and non-surgical interventions is essential for advancing patient care.

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“…No significant differences exist in the overall survival (OS) or recurrence-free survival (RFS) between lobectomy and sublobectomy in clinical stage IA non small cell lung cancer (NSCLC) ≤2 cm. [1] Besides, the studies on surgical methods in early LIMA are limited. In this study, we reviewed the clinicopathological features of LIMA and compared its prognosis under different surgical methods.…”

mentioning

confidence: 99%

Long-term outcomes of lobectomy vs. sublobectomy for stage I lung invasive mucinous adenocarcinoma

Wang,

Zhang,

Zheng

et al. 2024

Chinese Medical Journal

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Sublobar resection versus lobectomy for stage IA non-small-cell lung cancer ≤ 2 cm: a systematic review and patient-level meta-analysis

Cited by 5 publications

References 57 publications

Recent Advancements in Minimally Invasive Surgery for Early Stage Non-Small Cell Lung Cancer: A Narrative Review

Recent Advancements in Minimally Invasive Surgery for Early Stage Non-Small Cell Lung Cancer: A Narrative Review

Recent Advancements in Minimally Invasive Surgery for Early-Stage Non-Small Cell Lung Cancer: A Narrative Review

Long-term outcomes of lobectomy vs. sublobectomy for stage I lung invasive mucinous adenocarcinoma

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