Submandibular gland carcinoma ex pleomorphic adenoma clinically mimicking a benign lesion

Lubamba, Grace Paka; Guan, Jian; Wang, Yu; liang, Zhang Guo; Bo, Ning Shang; Peng, Dai Xin; Bushabu, Fidele Nyimi

doi:10.1016/j.omsc.2020.100166

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…It has a prevalence rate of 5.6 cases/100,000 malignant tumors and an incidence rate of CXPA is 0.17 tumors/1 million persons [ 10 ]. Although it usually presents with an uneventful rapidly growing mass, less commonly, it can present with pain, facial nerve palsy, enlarged lymph nodes, skin fixation, and ulceration [ 11 ]. CXPA usually spreads through a direct local extension and metastasis via lymphatic spread to cervical lymph nodes [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Carcinoma Ex Pleomorphic Adenoma of the Parotid Gland: A Rare Case

Umar¹,

Ilyas²,

Alshamam³

et al. 2022

Cureus

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Cancer is a major cause of morbidity and mortality worldwide, with squamous cell carcinoma (SCC) being the most common type. Even though SCC is the major type of cancer found in the head and neck region, the salivary glands contribute to about 1/20 cases, of which 1/10 are said to be carcinoma ex pleomorphic adenoma (CXPA) type, and the parotid gland is found to be the most common origin of such cases. Although it usually arises later in life, it can grow rapidly, with local symptoms being late findings, if any. Even though fine needle aspiration cytology has low sensitivity for diagnosing such cancer, multiple/repeated biopsies can increase the yield and the accuracy of the test. Surgical resection is the main choice for treatment with postoperative radiation for select cases. Our case presented with CXPA with distant metastasis to multiple sites.

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Section: Discussionmentioning

confidence: 99%

Carcinoma Ex Pleomorphic Adenoma of the Parotid Gland: A Rare Case

Umar¹,

Ilyas²,

Alshamam³

et al. 2022

Cureus

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Dendritic cell subpopulations in carcinoma ex‐pleomorphic adenoma: A multicenter study

Machado,

Gama‐Cuellar,

Scarini

et al. 2024

Oral Diseases

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ObjectiveCarcinoma ex‐pleomorphic adenoma (CEXPA) represents a malignant transformation from a recurrent or primary pleomorphic adenoma (PA), and the immune response may be essential in this process. Therefore, in this study, we aimed to identify and quantify subpopulations of dendritic cells (DCs) in CEXPA, residual PA in CEXPA (rPA), and PA.Materials and MethodsA multicenter study was performed collecting salivary gland tumor (SGT) samples from three Oral and Maxillofacial Pathology Centers. A tissue microarray containing 41 samples of CEXPA and 22 samples of PA was included in this study and submitted to immunohistochemical reactions against CD1a, CD83, CD207, and Ki67 antibodies.ResultsBoth PA and rPA showed a higher quantification of CD207+ and CD83+ cells when compared to CEXPA (p < 0.001 and p < 0.01, respectively). There was also a difference when comparing the cell proliferation index between PA/rPA and CEXPA using the Ki‐67 marker (p = 0.043). However, there was no difference in the DC population regarding clinical parameters such as sex, anatomical location, size, and metastases (p > 0.06).ConclusionsImmunohistochemical profile of DC subpopulations and cell proliferation biomarkers in SGTs can contribute as an important tool in the differentiation of benign and malignant tumors or detection of initial areas with malignant transformation.

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Never too young for a salivary gland carcinoma ex-pleomorphic adenoma

Fuad,

Guan,

Yunus

2024

Egypt J Otolaryngol

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Background Carcinoma ex-pleomorphic adenoma (CXPA) can either arise primarily as a de novo or from the malignant transformation of a benign pleomorphic adenoma (PA). CXPA mostly occurs in adults aged 50 to 70 years; hence, the occurrence of CXPA in younger ages is not common. Case presentation We report a 27-year-old female who had a history of submandibulectomy for pleomorphic adenoma, and presented with recurrent left submandibular swelling for 4 months. The mass was rapidly increasing in size and was associated with occasional throbbing pain. Examination showed a multilobulated, firm left submandibular swelling with no overlying skin changes. FNAC was performed twice, by conventional and ultrasound-guided techniques, and both concluded as benign salivary gland tumours. CT scan and MRI revealed a well-demarcated tumour with an area of necrosis within, with no obvious invasion into surrounding soft tissue and no significant lymphadenopathy. Having high suspicion of a malignant transformation, the tumour was resected with a concurrent modified radical neck dissection. The histopathological examination confirmed a carcinoma ex-pleomorphic adenoma with the myoepithelial malignant component. The patient subsequently received adjuvant radiotherapy. This case demonstrated that CXPA, although rare, can occur in young adults. Pre-operative FNAC and radiological imaging may mimic a pleomorphic adenoma. Conclusion The presence of recurrent tumours with rapid growth should alarm the clinician about a possible malignant transformation of a benign parotid tumour.

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Submandibular gland carcinoma ex pleomorphic adenoma clinically mimicking a benign lesion

Cited by 3 publications

References 28 publications

Carcinoma Ex Pleomorphic Adenoma of the Parotid Gland: A Rare Case

Carcinoma Ex Pleomorphic Adenoma of the Parotid Gland: A Rare Case

Dendritic cell subpopulations in carcinoma ex‐pleomorphic adenoma: A multicenter study

Never too young for a salivary gland carcinoma ex-pleomorphic adenoma

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