Submicrometer axial resolution optical coherence tomography

Považay, Boris; Bizheva, Kostadinka; Unterhuber, Angelika; Hermann, B.; Sattmann, Harald; Fercher, Adolf Friedrich; Drexler, Wolfgang; Apolonski, Alexander; Wadsworth, William J.; Knight, Jonathan C.; Russell, P. St. J.; Vetterlein, M.; Scherzer, E.

doi:10.1364/ol.27.001800

Cited by 450 publications

(221 citation statements)

References 13 publications

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“…However, it is difficult to broaden the emission bandwidth of a NIR SLD beyond $100 nm, which is one of the reasons for the limitation of the axial resolution in an OCT image to around $10 lm. Although alternative light sources have been developed for realizing high-resolution OCT, such as the use of a shortpulsed femtosecond laser 5 or supercontinuum generation in a photonic crystal fiber, 6 a SLD still offers the advantages of being a compact, robust, and inexpensive device compared with alternative light sources.…”

Section: Introductionmentioning

confidence: 99%

Superluminescent diode with a broadband gain based on self-assembled InAs quantum dots and segmented contacts for an optical coherence tomography light source

Ozaki

Childs

Sarma

et al. 2016

Journal of Applied Physics

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Articles you may be interested inBroadband InGaAs tapered diode laser sources for optical coherence radar and coherence tomography Appl. Phys. Lett. 86, 191101 (2005) We report a broadband-gain superluminescent diode (SLD) based on self-assembled InAs quantum dots (QDs) for application in a high-resolution optical coherence tomography (OCT) light source. Four InAs QD layers, with sequentially shifted emission wavelengths achieved by varying the thickness of the In 0.2 Ga 0.8 As strain-reducing capping layers, were embedded in a conventional p-n heterojunction comprising GaAs and AlGaAs layers. A ridge-type waveguide with segmented contacts was formed on the grown wafer, and an as-cleaved 4-mm-long chip (QD-SLD) was prepared. The segmented contacts were effective in applying a high injection current density to the QDs and obtaining emission from excited states of the QDs, resulting in an extension of the bandwidth of the electroluminescence spectrum. In addition, gain spectra deduced with the segmented contacts indicated a broadband smooth positive gain region spanning 160 nm. Furthermore, OCT imaging with the fabricated QD-SLD was performed, and OCT images with an axial resolution of $4 lm in air were obtained. These results demonstrate the effectiveness of the QD-SLD with segmented contacts as a highresolution OCT light source. V C 2016 AIP Publishing LLC.[http://dx

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Section: Introductionmentioning

confidence: 99%

Superluminescent diode with a broadband gain based on self-assembled InAs quantum dots and segmented contacts for an optical coherence tomography light source

Ozaki

Childs

Sarma

et al. 2016

Journal of Applied Physics

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“…With typical light sources, for instance superluminescent diodes (SLD), a resolution around 5 -10 µm in tissue (n ≈ 1.4) is possible, while ultra broadband light sources, e. g. supercontinuum sources, enable a resolution down to 1 µm [5,6]. Most optical microscopy techniques, such as confocal microscopy [8], achieve high resolution with a high numerical aperture (NA) objective.…”

Section: Figures Of Meritmentioning

confidence: 99%

“…It is capable of providing realtime cross-sectional images ( Fig. 1), resolving features typically on the order of 10 µm, but even depth resolution down to 1 µm or less is possible [5][6][7]. The penetration depth into scattering samples is limited; in biologic tissues typically to a few millimeters, which is nevertheless higher than other high-resolution optical techniques, e. g. confocal microscopy [8], can achieve.…”

Section: Introductionmentioning

confidence: 99%

Optical coherence tomography—current technology and applications in clinical and biomedical research

et al. 2011

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Optical coherence tomography (OCT) is a non-invasive imaging technique providing real-time twoand three-dimensional images of scattering samples with micrometer resolution. Mapping the local reflectivity, OCT visualizes the morphology of the sample. In addition, functional properties such as birefringence, motion or the distribution of certain substances can be detected with high spatial resolution. The main field of application is bio-medical imaging and diagnostics. In ophthalmology, OCT is accepted as a clinical standard for diagnosing and monitoring treatment of a number of retinal diseases, and OCT is becoming an important instrument for clinical cardiology. New applications are emerging in various medical fields, e. g. early-stage cancer detection, surgical guidance, and early diagnosis of musculoskeletal diseases. OCT has also proven its value as a tool for developmental biology. The number of companies involved in manufacturing OCT systems has increased substantially during the last years-especially due to its success in opthalmology-and this technology can be expected to continue to spread into various fields of application.

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“…Retinal imaging also profits from the proposed processing techniques. have been demonstrated with time domain (TD) systems at resolutions of < 1 mm [6,7]. Optical coherence microscopy (OCM) using en face TD detection offers the benefit of coherence gating [1,8].…”

Section: Biophotonicsmentioning

confidence: 99%

Artefact reduction for cell migration visualization using spectral domain optical coherence tomography

Höfer¹,

Povazˇay²,

Hermann³

et al. 2011

Journal of Biophotonics

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Visualization of cell migration during chemotaxis using spectral domain optical coherence tomography (OCT) requires non‐standard processing techniques. Stripe artefacts and camera noise floor present in OCT data prevent detailed computer‐assisted reconstruction and quantification of cell locomotion. Furthermore, imaging artefacts lead to unreliable results in automated texture based cell analysis. Here we characterize three pronounced artefacts that become visible when imaging sample structures with high dynamic range, e.g. cultured cells: (i) time‐varying fixed‐pattern noise; (ii) stripe artefacts generated by background estimation using tomogram averaging; (iii) image modulations due to spectral shaping. We evaluate techniques to minimize the above mentioned artefacts using an 800 nm optical coherence microscope. Effect of artefact reduction is shown exemplarily on two cell cultures, i.e. Dictyostelium on nitrocellulose substrate, and retinal ganglion cells (RGC‐5) cultured on a glass coverslip. Retinal imaging also profits from the proposed processing techniques. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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Submicrometer axial resolution optical coherence tomography

Cited by 450 publications

References 13 publications

Superluminescent diode with a broadband gain based on self-assembled InAs quantum dots and segmented contacts for an optical coherence tomography light source

Superluminescent diode with a broadband gain based on self-assembled InAs quantum dots and segmented contacts for an optical coherence tomography light source

Optical coherence tomography—current technology and applications in clinical and biomedical research

Artefact reduction for cell migration visualization using spectral domain optical coherence tomography

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