Substance P and intensity of pruritus in hemodialysis and peritoneal dialysis patients

Śnit, Mirosław; Gawlik, Radosław; Łącka-Gaździk, Beata; Kuźniewicz, Roman; Dwornicki, M; Owczarek, Aleksander; Walaszczyk, Małgorzata; Grabiec, P.; Grzeszczak, W

doi:10.12659/msm.889349

Cited by 11 publications

(6 citation statements)

References 40 publications

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“…Dialysis duration is an important factor affecting the prevalence of CKD-associated pruritus. Our findings indicated that the dialysis duration was negatively associated with the prevalence of CKD-associated pruritus, which was different from previous reports [11,17,35,43,45,50–54] that revealed no correlation between the 2. The following reasons could explain this phenomenon.…”

Section: Discussioncontrasting

confidence: 99%

“…This meta-analysis showed that the pooled prevalence of CKD-associated pruritus in HD and PD was 55% and 56%, respectively. While some previous studies [11,63,67] had shown similar results, Min et al [10] found that HD patients had a higher prevalence of CKD-associated pruritus than PD patients. Moreover, Wu et al [9] found that HD patients had a significantly higher severity of CKD-associated pruritus than PD patients, while Mistik et al [68] showed the opposite results.…”

Section: Discussionmentioning

confidence: 59%

“…Moreover, 22 studies assessed CKD-associated pruritus by other validated and invalid study tools. Thirty-six (85%) studies (10,003 patients) [8,16–18,29–60] only included HD patients, 2 (5%) studies (403 patients) [61,62] only included PD patients, and 4 (10%) studies (1394 patients) [9–11,63] included both HD and PD patients.…”

Section: Resultsmentioning

confidence: 99%

“…[7,8] Patients with peritoneal dialysis (PD) or hemodialysis (HD) suffer from different CKD-associated pruritus at different rates, which requires further study. [9–11]…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of chronic kidney disease-associated pruritus among adult dialysis patients

Sang

Yang

et al. 2018

Medicine

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Chronic kidney disease (CKD)-associated pruritus is a common adverse symptom in patients with end-stage renal disease treated by dialysis. Herein, a systematic review and meta-analysis of the prevalence of CKD-associated pruritus among adult dialysis patients was conducted.An electronic search of PubMed, Web of Science, Elsevier, Wanfang, and Chinese National Knowledge Infrastructure databases was conducted from inception to November 23, 2016, and all cross-sectional studies that reported the prevalence of CKD-associated pruritus in dialysis were collected. The pooled prevalence was estimated by random-effects model. Potential publication bias was evaluated by the funnel plot as well as Begg and Egger tests.After rigorous screening, a total of 42 studies conducted on 11,800 patients were included in this study. The overall prevalence of CKD-associated pruritus among adult dialysis patients was 55% (95% confidence interval [CI], 49-61, I = 97.6%), the stratification of which was 55% (95% CI, 45-65, I = 94.7%) in men and 55% (95% CI, 46-65, I = 93.3%) in women. In hemodialysis (HD) patients, the prevalence of CKD-associated pruritus was 55% (95% CI, 49-62, I = 97.9%), while in peritoneal dialysis (PD) patients, it was 56% (95% CI, 44-68, I = 89.9%). The prevalence of CKD-associated pruritus for mean dialysis duration <40 months was 56% (95% CI, 48-63, I = 75.1%), while that for mean dialysis duration ≥40 months was 50% (95% CI, 36-64, I = 99.1%).The prevalence of CKD-associated pruritus is high in HD and PD. The prevalence among adult dialysis patients is comparable between China and foreign countries as well as between females and males. Studies with the similar disease definition and analysis of the effects of risk factors on CKD-associated pruritus are needed.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 59%

Section: Resultsmentioning

confidence: 99%

“…[7,8] Patients with peritoneal dialysis (PD) or hemodialysis (HD) suffer from different CKD-associated pruritus at different rates, which requires further study. [9–11]…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of chronic kidney disease-associated pruritus among adult dialysis patients

Sang

Yang

et al. 2018

Medicine

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“…However, few studies have directly compared the characteristics of uremic pruritus between patients with PD and HD, and their results are controversial. 15 – 20 Some studies reported similar prevalence of uremic pruritus among patients receiving PD and HD, 16 – 20 whereas other study found differences in favor of PD. 15 Furthermore, the current standard for dialysis adequacy of solute clearance has not been considered in these studies.…”

Section: Introductionmentioning

confidence: 99%

A Comparison of Uremic Pruritus in Patients Receiving Peritoneal Dialysis and Hemodialysis

Peng

Chen

et al. 2016

Medicine

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Uremic pruritus is common and bothersome in patients receiving either peritoneal dialysis (PD) or hemodialysis (HD). To date, the preferred dialysis modality regarding the alleviation of uremic pruritus remains controversial. We conducted this cross-sectional study to compare the prevalence, intensity, and characteristics of uremic pruritus between PD and HD patients.Patients receiving maintenance dialysis at a referral medical center in Taiwan were recruited. Dialysis modality, patient demographic, clinical characteristics, and laboratory data were recorded. The intensity of uremic pruritus was measured using visual analogue scale (VAS) scores. Multivariate linear regression analysis was conducted to compare the severity of uremic pruritus between PD and HD patients. Generalized additive models were applied to detect nonlinear effects between pruritus intensity and continuous covariates.A total of 380 patients completed this study, with a mean age of 60.3 years and 49.2% being female. Uremic pruritus was presented in 24 (28.6%) of the 84 PD patients and 113 (38.2%) of the 296 HD patients (P = .12). The VAS score of pruritus intensity was significantly lower among the PD patients than the HD patients (1.32 ± 2.46 vs 2.26 ± 3.30, P = .04). Multivariate linear regression analysis showed that PD was an independent predictor for lower VAS scores of pruritus intensity compared with HD (β-value −0.88, 95% confidence interval −1.62 to −0.13). The use of active vitamin D was also an independent predictor for a lower intensity of uremic pruritus, whereas hyperphosphatemia and higher serum levels of triglyceride and aspartate transaminase were significantly associated with higher pruritus intensity. There was a trend toward a less affected body surface area of uremic pruritus in the PD patients than in the HD patients, but the difference did not reach statistical significance (P = .13).In conclusion, the severity of uremic pruritus was lower among PD patients than HD patients, and PD may provide better alleviation of pruritus symptoms. The result provides a valuable reference for clinicians and patients when choosing a dialysis modality.

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Pruritus

Teixeira¹,

Combs²,

Germain³

2022

Evidence‐Based Nephrology

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Substance P and intensity of pruritus in hemodialysis and peritoneal dialysis patients

Cited by 11 publications

References 40 publications

Prevalence of chronic kidney disease-associated pruritus among adult dialysis patients

Prevalence of chronic kidney disease-associated pruritus among adult dialysis patients

A Comparison of Uremic Pruritus in Patients Receiving Peritoneal Dialysis and Hemodialysis

Pruritus

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