Substance P facilitates memory in goldfish in an appetitively motivated learning task

Mattioli, Rosana; Santangelo, Erika Mattos; Costa, Ana C.C.; Vasconcelos, Luciana Mabel Ferreira

doi:10.1016/s0166-4328(96)00166-0

Cited by 30 publications

(14 citation statements)

References 22 publications

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“…In addition to pain mediation, the neuropeptide substance P is involved in learning, memory and reward processes in mammals, and its effects may be mediated through dopaminergic systems (Mattioli et al, 1995). In fish, as in mammals, dopaminergic cell bodies can be located at similar brain regions where substance P terminals are found (Mattioli et al, 1997). Using an appetitively motivated learning task, Mattioli et al (1997) demonstrated that substance P treatment has a similar effect on the memory and reward system of goldfish, and that these effects are also mediated by dopaminergic systems.…”

Section: Dopaminergic Systemsmentioning

confidence: 99%

“…In fish, as in mammals, dopaminergic cell bodies can be located at similar brain regions where substance P terminals are found (Mattioli et al, 1997). Using an appetitively motivated learning task, Mattioli et al (1997) demonstrated that substance P treatment has a similar effect on the memory and reward system of goldfish, and that these effects are also mediated by dopaminergic systems. In addition, Santangelo et al (2001) showed that substance P improved learning and memory processes of goldfish during avoidance testing, and implicated ventral telencephalic structures in mediating such processes.…”

Section: Dopaminergic Systemsmentioning

confidence: 99%

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Can fish suffer?: perspectives on sentience, pain, fear and stress

Chandroo

Duncan

Moccia

2004

Applied Animal Behaviour Science

340

165

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In contrast to other major forms of livestock agriculture, there is a paucity of scientific information on the welfare of fish raised under intensive aquacultural conditions. This reflects an adherence to the belief that these animals have not evolved the salient biological characteristics that are hypothesised to permit sentience. In this review, we evaluate the scientific evidence for the existence of sentience in fish, and in particular, their ability to experience pain, fear and psychological stress. Teleost fish are considered to have marked differences in some aspects of brain structure and organization as compared to tetrapods, yet they simultaneously demonstrate functional similarities and a level of cognitive development suggestive of sentience. Anatomical, pharmacological and behavioural data suggest that affective states of pain, fear and stress are likely to be experienced by fish in similar ways as in tetrapods. This implies that fish have the capacity to suffer, and that welfare consideration for farmed fish should take these states into account. We suggest that the concept of animal welfare can be applied legitimately to fish. It is therefore appropriate to recognize and study the welfare of farmed fish.

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Section: Dopaminergic Systemsmentioning

confidence: 99%

Section: Dopaminergic Systemsmentioning

confidence: 99%

Can fish suffer?: perspectives on sentience, pain, fear and stress

Chandroo

Duncan

Moccia

2004

Applied Animal Behaviour Science

340

165

View full text Add to dashboard Cite

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“…Nomenclature and subdivisions based on Reiner et al (2004). thies, 1982;Schlesinger et al, 1986;Tomaz and Huston, 1986;Tomaz and Nogueira, 1997) and fish (Mattioli et al, 1997;Santangelo et al, 2001). Moreover, chronic SP administration reverses age-related memory deficits in rats (Hasenohrl et al, 1994).…”

mentioning

confidence: 99%

Distribution of substance P reveals a novel subdivision in the hippocampus of parasitic South American cowbirds

Nair-Roberts

Erichsen

Reboreda

et al. 2006

J of Comparative Neurology

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Parasitic cowbirds monitor potential hosts' nests and return to lay when appropriate, a task that is likely to involve spatial recall. Seasonal and sexual behavioral variations in the cowbirds correlate with anatomical changes in the hippocampal formation. During the breeding season, parasites have larger hippocampal formations than nonparasites. In parasitic species in which females alone perform nest bookkeeping, females have larger hippocampal formations than males. We investigated the distribution of the neuropeptide substance P (SP) in three sympatric cowbirds: two obligate parasites (shiny cowbird and screaming cowbird) and one nonparasite (bay-winged cowbird). Distribution of SP was similar to that in other songbirds, except for a previously undescribed field of dense SP-rich terminals within the hippocampus that we call the hippocampal SP terminal field (SPh). We found robust species differences in the volume of this new area, measured relative to the remainder of the telencephalon. SPh was largest in the generalist parasite (shiny cowbird) and smallest in the nonparasitic species (bay-winged cowbird). In the specialist parasite (screaming cowbird), SPh was smaller than in the generalist parasite but larger than in the nonparasitic species. SPh overlaps with two subdivisions described in the pigeon that have been related to the mammalian dentate gyrus and subiculum. The area containing SPh receives a major input from the lateral mammillary nucleus, which is probably the avian equivalent of the mammalian supramammillary nucleus (SUM), the main source of extrinsic SP input to mammalian hippocampus. SPh may be the termination of a pathway homologous to the SP-rich projection from SUM to the hippocampus in mammals.

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“…Both SP and ACTH have been shown to promote learning and memory (Greven & de Wied, 1973;de Wied & Gispen, 1977;Stiubli & Huston, 1980;Wetzel & Matthies, 1982;Tomaz & Huston, 1986;Tomaz et al, 1990;Wan et al, 1992;Huston & Hasen6hrl, 1995;Mattioli et al, 1997), and to have reinforcing effects in rats and goldfish (Huston & Oitzl, 1989;Oitzl et al, 1990;Huston & Hasen6hrl, 1995;Mattioli et al, 1995;, and such effects may facilitate functional recovery, for example, by improving behavioral compensation and re-learning. Effects on learning might also explain why the peptides acted rather rapidly and why their effectiveness outlasted drug discontinuation.…”

Section: Resultsmentioning

confidence: 99%

ACTH4 ‐10, Substance P, and Dizolcipine (Mk‐801) Accelerate Functional Recovery After Hemilabyrinthectomy in Goldfish

2000

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SUMMARYIn this study, we evaluated the goldfish model of hemilabyrinthectomy for investigating potential recovery-promoting drugs. In this lesion model, the unilateral removal of the labyrinth induces a postural imbalance in response to light (Dorsal Light Reflex), from which the animals can recover over time. The behavioral effects of two neuropeptides were testednamely, of substance P and ACTH4-10, both of which are known to promote functional recovery in several other lesion models. Furthermore, the effect of MK-801, an antagonist of the glutamatergic NMDAreceptor subtype, was tested because this substance has also been shown to exert a neuroprotective effect. After lesion of the right labyrinth, the animals (n=12) were treated intraperitoneally daily either with vehicle (n=12), substance P (n=ll),

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Substance P facilitates memory in goldfish in an appetitively motivated learning task

Cited by 30 publications

References 22 publications

Can fish suffer?: perspectives on sentience, pain, fear and stress

Can fish suffer?: perspectives on sentience, pain, fear and stress

Distribution of substance P reveals a novel subdivision in the hippocampus of parasitic South American cowbirds

ACTH4 ‐10, Substance P, and Dizolcipine (Mk‐801) Accelerate Functional Recovery After Hemilabyrinthectomy in Goldfish

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