Substance P receptor in the rat indusium griseum during postnatal development

Barbaresi, Paolo

doi:10.1016/j.neures.2017.08.007

Cited by 7 publications

(5 citation statements)

References 52 publications

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“…The distribution of nNOS neurons in IG seems to be strictly related to the vascular anatomy of CC. The presence of nNOS neurons at the IG/CC boundary points to a role of these neurons in the IG/CC communication, as already hypothesized by recent immunohistochemical findings in rat IG (Barbaresi 2018 ). These neurons could be similar to those recently observed in layer III of IG which were positive to calbindin (Bobić Rasonja et al 2021 ; Sanders et al 2021 ), a protein that has a threefold function as buffer, transporter and likely as a non-canonical sensor of Ca 2+ (Schmidt 2012 ).…”

Section: Discussionsupporting

confidence: 78%

“…A very recent paper in humans (Bobić Rasonja et al 2021 ) found that IG is developmentally distinct from the hippocampal formation; in addition, it exhibits continuous maturation, also in the final trimester of gestation, without signs of regression during the fetal period; this suggests that IG is not a rudimentary tissue, but may play a functional role in the adult brain (Bobić Rasonja et al 2021 ). Moreover, a Golgi (Wyss and Sripanidkulchai 1983 ) and an immunocytochemical study (Barbaresi 2018 ) described the presence of neurons within the rat IG. In accordance with previous studies, Lorenzi et al ( 2019 ) confirmed that human IG contains neurons, and that some of them are immunopositive to neuronal nitric oxide synthase (nNOS), the enzyme responsible for the synthesis of nitric oxide (NO).…”

Section: Introductionmentioning

confidence: 99%

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Neuronal nitric oxyde synthase positive neurons in human indusium griseum

et al. 2022

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The study was designed to analyze the nNOS positive neurons present in the indusium griseum by describing their distribution and morphology. To this purpose, sagittal serial sections from paraffin or frozen autopsy specimens of corpus callosum including the overlying indusium griseum were processed by immunohistochemistry and immunofluorescence, using an antibody against the neuronal form of the enzyme nitric oxyde synthase. To test the specificity of the antibody used, Western Blot was performed in the indusium griseum of the same specimens. The stainings revealed the presence of many neuronal nitric oxyde synthase-immunopositive neurons in human indusium griseum, located along both rostral-caudal and medio-lateral directions. In particular, they were more numerous 1 mm apart from the midline, and their number peaked over the body of the corpus callosum. They showed different morphologies; in some cases, they were located at the boundary between indusium griseum and corpus callosum, more densely packed in proximity to the pial arteries penetrating into the corpus callosum. The significant presence and distribution of neuronal nitric oxyde synthase-immunopositive neurons suggests that indusium griseum likely plays a functional role in the neurovascular regulation within the corpus callosum. Graphical abstract Schematic representation of human adult IG and the neurovascular unit originating from sopracallosal artery (Sca) that branches into smaller arterioles (Br) (created in PowerPoint). The arterioles cross the three layers of IG (layers I, II and III) and penetrate into the CC separated from IG by the Virchow-Robin space (VRs). As the arterioles go deeper, this space disappears and the vascular basement membrane comes into direct contact with the astrocytic end-feets (intracallosal arterioles and capillaries). nNOS-immunopositive neurons (nNOSIP N) surround the arterioles and control the vasomotore tone secreting nitric oxyde (NO). Two morphological types of nNOSIP N can be appreciated by the use of different colors: fusiform (blue) and ovoidal (pink). Also NeuN-immunopositive neurons (N) and many astrocytes (As) are present, more numerous in IG than in CC.

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Section: Discussionsupporting

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Neuronal nitric oxyde synthase positive neurons in human indusium griseum

et al. 2022

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“…Thus, the presence of neurons and of nNOS positive neuronal-like cells in IG suggest that it is not a merely rudimentary tissue, 4 but likely plays a functional role in the adult brain. As evidenced by a recent immunohistochemical paper 5 the rat IG contains neurons expressing neurokinin-1 receptor, sending fibers to the underlying CC and to the cingulate cortex (Cg). Altogether, these observations suggest an intercommunication among IG, CC and Cg, leading to the hypothesis that CC lesioning could provoke functional detrimental effects.…”

mentioning

confidence: 99%

Letter: The Indusium Griseum: Anatomic Study with Potential Application to Callosotomy

et al. 2019

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To the Editor:We read with great interest the paper by Tubbs et al 1 describing the human indusium griseum (IG) to be a glial membrane above the corpus callosum (CC) without neuronal cells nor connections with the hippocampus. The study, carried out by magnetic resonance imaging and histological and immunohistochemical (ihc) techniques, led the Authors to conclude that transection of this membrane, unavoidable when performing callosotomy (ie, to relieve drug-resistant epilepsy), FIGURE. Sagittal sections of IG. A, B, Staining of IG by Luxol fast blu A and eosin B. The identification of IG is possible thanks to the orientation of its fibers which travel perpendicularly to those of the CC. C, nNOS-positive cells (arrows) are present within the IG, often at the border with CC. Several IG areas contain nNOS-positive nerve fibers (arrowheads). D, NEUN-positive cells are distributed throughout the entire IG (arrows). Scale bars, 100 μm.

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“…P50 and p65 are then released and transferred to the nucleus, resulting in the binding to κB sites on nuclear DNA. Hence, inflammatory factors gene transcription is initialized and further causes the overexpression of multiple cytokines that induce neurogenic inflammation (Conti et al, 2019;Ramachandran, 2018) (Barbaresi, 2018;McCleane, 2004;White, Targett, & Harris, 2018). Moreover, five main ingredients (1-dodecanol, elemene, palmitic acid ethyl ester, a-pinene, and 1-pentadecanol) were detected using the GC-MS method, among which 1-dodecanol occupied 13.71% (J. .…”

Section: Migraine Pathogenesismentioning

confidence: 99%

“…When ENK combines with opioid peptide receptors (DORR), pain signaling transmission is suppressed in the periaqueductal gray (PAG). Meanwhile, antagonistic neuropeptide cholecystokinin (CCK) competes with ENK for DORR, which further underpins central pain sensitization and thus triggers migraine headache (Barbaresi, 2018; McCleane, 2004; White, Targett, & Harris, 2018).…”

Section: Migraine Pathogenesismentioning

confidence: 99%

Role of herbal medicine for prevention and treatment of migraine

Chen

Wang

2021

Phytotherapy Research

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Migraine is a disabling neurovascular disease with unilateral or bilateral pulsatile headache, which intensively affects human health and quality of life due to high morbidity worldwide. Migraine is commonly accompanied by abnormal pain sensitization, neuroinflammatory response, and vasomotor dysfunction. Owing to the management dilemmas of migraine, there is an urgent need to develop effective and low-cost therapies. In recent years, herbal medicines as a promising strategy with analgesic activity and minor side effect, have been proposed for the prevention and treatment of migraine. Considering the lack of a review integrating experimental studies regarding the herbal treatment of migraine, this review systematically summarizes the important potential applications of herbal medicines in ameliorating migraine via multiple therapeutic targets and pathways, as well as provides a reference for further development of novel antimigraine drugs.

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Substance P receptor in the rat indusium griseum during postnatal development

Cited by 7 publications

References 52 publications

Neuronal nitric oxyde synthase positive neurons in human indusium griseum

Neuronal nitric oxyde synthase positive neurons in human indusium griseum

Letter: The Indusium Griseum: Anatomic Study with Potential Application to Callosotomy

Role of herbal medicine for prevention and treatment of migraine

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