Substantive antimicrobial activity in chlorhexidine-treated human root dentin

Basrani, Bettina; Santos, João Miguel; Tjäderhane, Leo; Grad, Helen; Görduysus, Melahat; Huang, Jia; Lawrence, Herenia P.; Friedman, Shimon

doi:10.1067/moe.2002.124002

Cited by 154 publications

(173 citation statements)

References 35 publications

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“…62 Chlorhexidine exhibits substantivity to dentin and consequently may present residual antimicrobial effects for days to weeks and help prevent root canal reinfection. 52,[63][64][65][66][67][68][69] This seems to be an important advantage over NaOCl. Nevertheless, one important disadvantage of chlorhexidine is that it lacks tissue-dissolving ability, which is one of the obvious benefits of NaOCl.…”

Section: Discussionmentioning

confidence: 99%

Bacteriologic investigation of the effects of sodium hypochlorite and chlorhexidine during the endodontic treatment of teeth with apical periodontitis

Siqueira

Rôças

Paiva

et al. 2007

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

146

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Objective. This clinical study was undertaken to compare the effectiveness of 2.5% sodium hypochlorite (NaOCl) and 0.12% chlorhexidine digluconate as irrigants in reducing the cultivable bacterial populations in infected root canals of teeth with apical periodontitis. Study design. According to stringent inclusion/exclusion criteria, 32 teeth with primary intraradicular infections and chronic apical periodontitis were selected and followed in the study. Bacterial samples were taken at the baseline (S1) and after chemomechanical preparation using either NaOCl (n ϭ 16) or chlorhexidine (n ϭ 16) as irrigants (S2). Cultivable bacteria recovered from infected root canals at the 2 stages were counted. Isolates from S2 samples were identified by means of 16S rRNA gene sequencing analysis.

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Section: Discussionmentioning

confidence: 99%

Bacteriologic investigation of the effects of sodium hypochlorite and chlorhexidine during the endodontic treatment of teeth with apical periodontitis

Siqueira

Rôças

Paiva

et al. 2007

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

146

View full text Add to dashboard Cite

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“…Therefore, medicating the canal with a more concentrated CHX preparation should result in increased resistance to microbial colonization. 101 In large bovine root canals, 0.2% CHX imparted substantivity whereas in smaller human root canals a higher concentration of CHX was required to achieve a comparable effect.…”

Section: Chlorhexidinementioning

confidence: 99%

“…56,[96][97][98][99][100][101] The positively-charged molecules of CHX can adsorb onto dentine and prevent microbial colonization on the dentine surface for some time beyond the actual medication period 101 -this may inhibit re-infection of the canal subsequent to treatment 98 during that time period. CHX is retained in root canal dentine in levels sufficient to exert antimicrobial effects for at least 12 weeks.…”

Section: Chlorhexidinementioning

confidence: 99%

The use of calcium hydroxide, antibiotics and biocides as antimicrobial medicaments in endodontics

Athanassiadis

Abbott

Walsh

2007

Australian Dental Journal

300

278

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Bacteria have been implicated in the pathogenesis and progression of pulp and periapical diseases. The primary aim of endodontic treatment is to remove as many bacteria as possible from the root canal system and then to create an environment in which any remaining organisms cannot survive. This can only be achieved through the use of a combination of aseptic treatment techniques, chemomechanical preparation of the root canal, antimicrobial irrigating solutions and intracanal medicaments. The choice of which intracanal medicament to use is dependent on having an accurate diagnosis of the condition being treated, as well as a thorough knowledge of the type of organisms likely to be involved and their mechanisms of growth and survival. Since the disease is likely to have been caused by the presence of bacteria within the root canal, the use of an antimicrobial agent is essential. Many medicaments have been used in an attempt to achieve the above aims but no single preparation has been found to be completely predictable or effective. Commonly used medicaments include calcium hydroxide, antibiotics, non-phenolic biocides, phenolic biocides and iodine compounds. Each has advantages and disadvantages, and further research is required to determine which is best suited for root canal infections.Key words: Endodontics, bacteria, antimicrobial, medicaments.Abbreviations and acronyms: Ca(OH) 2 = calcium hydroxide; CFU = colony forming units; CHX = chlorhexidine; CMP = camphorated monochlorophenol; CP = camphorated phenol; IPI = iodine potassium iodide; LPS = lipopolysaccharide; NaOCI = sodium hypochlorite; PEG = polyethyleneglycol; PMCP = paramonochlorophenol; QAC = quaternary ammonium compounds.

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“…Basrani et al (6) found a brown colour precipitate when chlorhexidine was mixed with sodium hypochlorite in the test tube and parachloraniline (PCA) was found when this precipitate subjected to gas chromatography (14,15). This precipitate is an insoluble neutral salt formed by the acid base reaction between NaOCl and CHX.…”

Section: Discussionmentioning

confidence: 99%

Comparing the Effect of Irrigation With 70% Isopropyl Alcohol, Distilled Water and Saline to Remove the Residual Sodium Hypochlorite before Irrigation with Chlorhexidine in Root Canal Therapy – An In Vitro Study

Singh¹,

Tudu²,

Munda³

et al. 2017

IOSR JDMS

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Substantive antimicrobial activity in chlorhexidine-treated human root dentin

Abstract: Canal dressing for 1 week with 2% CHX may provide residual antimicrobial activity against E faecalis.

Cited by 154 publications

References 35 publications

Bacteriologic investigation of the effects of sodium hypochlorite and chlorhexidine during the endodontic treatment of teeth with apical periodontitis

Bacteriologic investigation of the effects of sodium hypochlorite and chlorhexidine during the endodontic treatment of teeth with apical periodontitis

The use of calcium hydroxide, antibiotics and biocides as antimicrobial medicaments in endodontics

Comparing the Effect of Irrigation With 70% Isopropyl Alcohol, Distilled Water and Saline to Remove the Residual Sodium Hypochlorite before Irrigation with Chlorhexidine in Root Canal Therapy – An In Vitro Study

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