Substrate independent silver nanoparticle based antibacterial coatings

Taheri, Shima; Cavallaro, Alex; Christo, Susan N; Smith, Louise E.; Majewski, Peter; Barton, Mary; Hayball, John D.; Vasilev, Krasimir

doi:10.1016/j.biomaterials.2014.02.033

Cited by 138 publications

(107 citation statements)

References 46 publications

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“…There is abundant research focusing on the antibacterial activity of Ag NPs. [3][4][5] Inhibition of bacterial growth was observed for both Gram-positive and Gram-negative bacteria, 5 and no resistance has been convincingly demonstrated for clinically-relevant pathogens. 4 Moreover, the bactericidal properties of Ag NPs are superior to other silver compounds, 6 and it has diverse applications in the form of wound dressings, medical device coatings, Ag NP-impregnated textile fabrics, etc.…”

Section: Introductionmentioning

confidence: 99%

“…10,11 It is evident that Ag NPs can be ionized after entering the cells, and induce a series of proinflammatory responses, markedly increasing the expression of TNF-α. 4,12 They have also been shown to cause cell death in vitro, including macrophage cells, liver cells, and neuronal cells. [13][14][15] In addition, liver damage and decrease in several red blood cell parameters induced by Ag NPs were confirmed in vivo.…”

Section: Introductionmentioning

confidence: 99%

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Ag-plasma modification enhances bone apposition around titanium dental implants: an animal study in Labrador dogs

Qiao

Cao

Zhao

et al. 2015

IJN

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Dental implants with proper antibacterial ability as well as ideal osseointegration are being actively pursued. The antimicrobial ability of titanium implants can be significantly enhanced via modification with silver nanoparticles (Ag NPs). However, the high mobility of Ag NPs results in their potential cytotoxicity. The silver plasma immersion ion-implantation (Ag-PIII) technique may remedy the defect. Accordingly, Ag-PIII technique was employed in this study in an attempt to reduce the mobility of Ag NPs and enhance osseointegration of sandblasted and acid-etched (SLA) dental implants. Briefly, 48 dental implants, divided equally into one control and three test groups (further treated by Ag-PIII technique with three different implantation parameters), were inserted in the mandibles of six Labrador dogs. Scanning electron microscopy, X-ray photoelectron spectroscopy, and inductively coupled plasma optical emission spectrometry were used to investigate the surface topography, chemical states, and silver release of SLA- and Ag-PIII-treated titanium dental implants. The implant stability quotient examination, Microcomputed tomography evaluation, histological observations, and histomorphometric analysis were performed to assess the osseointegration effect in vivo. The results demonstrated that normal soft tissue healing around dental implants was observed in all the groups, whereas the implant stability quotient values in Ag-PIII groups were higher than that in the SLA group. In addition, all the Ag-PIII groups, compared to the SLA-group, exhibited enhanced new bone formation, bone mineral density, and trabecular pattern. With regard to osteogenic indicators, the implants treated with Ag-PIII for 30 minutes and 60 minutes, with the diameter of the Ag NPs ranging from 5–25 nm, were better than those treated with Ag-PIII for 90 minutes, with the Ag NPs diameter out of that range. These results suggest that Ag-PIII technique can reduce the mobility of Ag NPs and enhance the osseointegration of SLA surfaces and have the potential for future use.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ag-plasma modification enhances bone apposition around titanium dental implants: an animal study in Labrador dogs

Qiao

Cao

Zhao

et al. 2015

IJN

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“…6 Briey, 12 ml of 2 mM AgNO 3 was mixed with 5 ml of 2 mM MSA under ice cold condition. 0.5 ml of 0.5 M of NaBH 4 was added to the solution under vigorous stirring.…”

Section: Synthesis Of Agnps@msamentioning

confidence: 99%

“…In this work, we used established platforms for generation of antibacterial surfaces combining plasma polymer coatings and silver nanoparticles. 6 These types of surfaces were selected since they were demonstrated in our previous work to have excellent antibacterial properties but no toxicity to primary human broblasts or MSCs. The method of preparation also allowed us to generate two different silver nanoparticle surface concentrations which facilitated examination of dose dependent effects.…”

mentioning

confidence: 99%

“…The method of preparation also allowed us to generate two different silver nanoparticle surface concentrations which facilitated examination of dose dependent effects. 6,12 The effect of the silver nanoparticle modied surface on the attachment, proliferation, viability, spreading and differentiation of mKSCs was evaluated via microscopic and immunostaining techniques.…”

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confidence: 99%

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Silver nanoparticle modified surfaces induce differentiation of mouse kidney-derived stem cells

et al. 2018

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In this paper, we interrogate the influence of silver nanoparticle (AgNPs)-based model surfaces on mouse kidney-derived stem cells (mKSCs) differentiation. The widespread use of silver in biomedical and consumer products requires understanding of this element's effect on kidney cells. Moreover, the potential for using stem cells in drug discovery require methods to direct their differentiation to specialized cells. Hence, we generated coated model substrates containing different concentrations of surface immobilized AgNPs, and used them to evaluate properties and functions of mKSCs. Initially, mKSCs exhibited reduced viability on higher silver containing surfaces. However, longer culture periods assisted mKSCs to recover. Greater degree of cell spreading and arborization led by AgNPs, suggest podocyte differentiation. Proximal tubule cell marker's expression revealed differentiation to the specific lineage. Although the exact mechanism underpinning these findings require significant future efforts, this study demonstrate silver's capacity to stimulate mKSC differentiation, which may provide opportunities for drug screenings.

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