Substrate induced generation of transient self-assembled catalytic systems

Abstract

This review highlights the studies which show substrate induced generation of transient catalytic moieties. Examples have been discussed with keeping an eye on the design strategies for development of non-equilibrium high energy assemblies as seen in Nature.

Systems chemistry of peptide-assemblies for biochemical transformations

“…175 Over the last decade, the quest for accessing such dynamic catalytic structures that are transiently formed in the presence of chemical fuels has gained significant interest in the emerging field of systems chemistry. 50,51,[176][177][178][179][180][181][182] From the perspective of this review, we have included selected examples where transient self-assembly has been achieved utilizing enzyme like activity from assembled states of simple building blocks. These examples specifically utilize augmented catalytic performance from the self-assembled state to access transient self-assemblies under non-equilibrium conditions.…”

“…16,17 Looking beyond minimal systems that work close to equilibrium, extant enzymes and protein polymers of modern biology exploit energy sources to perform work away from equilibrium with remarkable spatiotemporal control, both via transient catalysis and compartmentalization. [48][49][50][51] In this regard, reports showing the generation of catalytic systems and compartments under non-equilibrium conditions utilizing simple synthetic precursors have attempted to shed light on how bioenergetics played an essential role in chemical evolution. 51,52 From the perspective of the emerging field of systems chemistry, in this review, we have focused on recent developments towards the understanding of short peptide based catalytic assemblies.…”

“…[48][49][50][51] In this regard, reports showing the generation of catalytic systems and compartments under non-equilibrium conditions utilizing simple synthetic precursors have attempted to shed light on how bioenergetics played an essential role in chemical evolution. 51,52 From the perspective of the emerging field of systems chemistry, in this review, we have focused on recent developments towards the understanding of short peptide based catalytic assemblies. First, the examples of the self-assembled systems with proximally located active residues are covered where diverse sets of advanced enzyme like chemical transformations have been accessed by short peptide based assemblies.…”

“…48–51 In this regard, reports showing the generation of catalytic systems and compartments under non-equilibrium conditions utilizing simple synthetic precursors have attempted to shed light on how bioenergetics played an essential role in chemical evolution. 51,52…”

Insights into chemically-fueled supramolecular polymers

“…Unlike biology, synthetic chemists are not restricted to natural fuels like ATP and GTP, amino acid building blocks, or even to aqueous solvents. The past decade has seen an exploration of suitable chemistries, switches, and monomers that can reproduce some aspects of dissipative self-assembly that make microtubules so mesmerizing (see recent reviews ) [5][6][7][8][9] .…”