2024
DOI: 10.1002/1873-3468.15042
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Substrate recognition by the 4‐hydroxytryptamine kinase PsiK in psilocybin biosynthesis

Kai Rogge,
Tobias Johannes Wagner,
Dirk Hoffmeister
et al.

Abstract: Psilocybin, the natural hallucinogen from Psilocybe (magic) mushrooms, is a highly promising drug candidate for the treatment of depression and several other mental health conditions. Biosynthesis of psilocybin from the amino acid l‐tryptophan involves four strictly sequential modifications. The third of these, ATP‐dependent phosphorylation of the intermediate 4‐hydroxytryptamine, is catalysed by PsiK. Here we present a crystallographic analysis and a structure‐based mutagenesis study of this kinase, providing… Show more

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