Substrate stiffness modulates extracellular vesicles’ release in a triple-negative breast cancer model
Beatrice Senigagliesi,
Otmar Geiss,
Stefano Valente
et al.
Abstract:Aim: The microenvironment effect on the tumoral-derived Extracellular Vesicle release, which is of significant interest for biomedical applications, still represents a rather unexplored field. The aim of the present work is to investigate the interrelation between extracellular matrix (ECM) stiffness and the release of small EVs from cancer cells. Here, we focus on the interrelation between the ECM and small extracellular vesicles (sEVs), specifically investigating the unexplored aspect of the influence of EC… Show more
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