Subthalamic Nucleus Deep Brain Stimulation in Primary Meige Syndrome: A 1-Year Follow-Up Study

Ouyang, Jia; Hao, Qingpei; Zhu, Runze; Wu, Guangyong; Ding, Hu; Wang, Dongliang; Liu, Ruen

doi:10.1111/ner.13174

Cited by 16 publications

(16 citation statements)

References 25 publications

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“…This not only verified the results of our previous study but also verified basal ganglia-thalamocortical motor circuit abnormalities as a pathogenic mechanism of Meige syndrome, and this abnormal metabolic pattern is regulated by STN-DBS. In addition, the baseline characteristics and clinical efficacy of the patients in this group were similar to those of previous studies at our center, which was representative ( Liu et al, 2020 , 2021a ; Ouyang et al, 2021 ). BFMDRS-M and BFMDRS-D scores were improved by 60.08 and 85.84%, respectively, confirming our previous findings that STN-DBS was effective for the treatment of Meige syndrome ( Liu et al, 2021a ).…”

Section: Discussionsupporting

confidence: 77%

“…The surgical procedure for bilateral STN-DBS was consistent with a previous study from our team ( Ouyang et al, 2020 ). In brief, patients underwent bilateral stereotactic surgery under local anesthesia.…”

Section: Methodsmentioning

confidence: 69%

“…The safety and efficacy of deep brain stimulation (DBS) have been gradually recognized, and it has become an important method for the treatment of Meige syndrome. Commonly used clinical targets include the globus pallidus internus (GPi) and subthalamic nucleus (STN), which have proven effective for the treatment of Meige syndrome by our research team ( Hao et al, 2020 ; Ouyang et al, 2021 ). Comparing the effects of these two targets, we also found that STN-DBS and GPi-DBS exerted similar effects in Meige syndrome ( Liu et al, 2021a ).…”

Section: Discussionmentioning

confidence: 99%

“…The globus pallidus internus (GPi) is the most widely targeted region in deep brain stimulation in Meige syndrome ( Tian et al, 2019 ; Hao et al, 2020 ). Our previous study also demonstrated the safety and efficacy of subthalamic nucleus (STN) DBS ( Ouyang et al, 2021 ), revealing that patients with Meige syndrome had similar improvements in motor function, quality of life and sleep after either GPi-DBS or STN-DBS ( Liu et al, 2021a ).…”

Section: Introductionmentioning

confidence: 91%

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Metabolic Imaging of Deep Brain Stimulation in Meige Syndrome

Liu

et al. 2022

Front. Aging Neurosci.

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ObjectivesThe subthalamic nucleus (STN) has been shown to be a safe and effective deep brain stimulation (DBS) surgical target for the treatment of Meige syndrome. The aim of this study was to compare changes in brain metabolism before and 6 months after STN-DBS surgery.MethodsTwenty-five patients with primary Meige syndrome underwent motor function assessment, including the Burke–Fahn–Marsden Dystonia Rating Scale movement (BFMDRS-M) and disability subscale (BFMDRS-D) and positron emission tomography with an 18[F]-fluorodeoxyglucose scan before and 6 months after STN-DBS surgery. For the voxelwise metabolic change assessment, the p-value was controlled for multiple comparisons using the familywise error rate.ResultsThere was a significant decrease in BFMDRS-M scores 6 months after STN-DBS, from 10.02 ± 3.99 to 4.00 ± 2.69 (p < 0.001). The BFMDRS-D scores also decreased significantly from 4.52 ± 2.90 to 0.64 ± 1.29 (p < 0.001). In the left hemisphere, hypermetabolism was found in the occipital lobe, superior parietal gyrus, postcentral gyrus and thalamus. In the right hemisphere, hypermetabolism was found in the lentiform nucleus, precuneus and precentral gyrus in patients with Meige syndrome receiving DBS. In addition, the bilateral inferior temporal gyrus and middle frontal gyrus exhibited glucose hypermetabolism.ConclusionOur findings indicate that STN-DBS has a significant effect on metabolic level in the brain, which may be an important mechanism for the treatment of Meige syndrome using STN-DBS.

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Section: Discussionsupporting

confidence: 77%

Section: Methodsmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 91%

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Metabolic Imaging of Deep Brain Stimulation in Meige Syndrome

Liu

et al. 2022

Front. Aging Neurosci.

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“…However, in our previous voxel-based morphological study, we did not observe the involvement of the basal ganglia and motor cortex in the pathophysiology of the disorder in Meige syndrome 5 . Our experiences with stereotaxic surgeries have revealed that deep brain stimulation (DBS) of the internal globus pallidus or subthalamic nucleus alleviates Meige syndrome 16 , 17 . The basal ganglia might be a key structure in the mechanisms underlying Meige syndrome.…”

Section: Discussionmentioning

confidence: 99%

Regional metabolic and network changes in Meige syndrome

Liu

et al. 2021

Sci Rep

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To contribute to the understanding of the aetiology and pathogenesis of Meige syndrome, the metabolic networks of patients with Meige syndrome were investigated using 18F-fluoro-D-glucose positron emission tomography (18F-FDG-PET) imaging of cerebral glucose metabolism. Fifty right-handed and unmedicated primary Meige syndrome patients enrolled between September 2017 and September 2020 at the Department of Neurosurgery, Peking University People’s Hospital, and 50 age- and sex-matched healthy control subjects participated in the study. Metabolic connectivity and graph theory analysis were used to investigate metabolic network differences based on 18F-FDG-PET images. Glucose hypometabolism was detected in the left internal globus pallidus and parietal lobe, right frontal lobe and postcentral gyrus, and bilateral thalamus and cerebellum of patients with Meige syndrome. Clustering coefficients (Cps) (density threshold: 16–28%; P < 0.05) and shortest path lengths (Lps) (density threshold: 10–15%; P < 0.05) were higher in Meige syndrome patients than in healthy controls. Small-worldness was lower in Meige syndrome patients than in healthy controls, and centrality was significantly lower in the right superior occipital gyrus and pallidum and higher in the right thalamus. Hypometabolism in the globus pallidus and thalamus may indicate basal ganglia-thalamocortical motor circuit abnormalities as a pathogenic mechanism of Meige syndrome, providing a possible explanation for the efficacy of deep brain stimulation (DBS) in improving symptoms. Meige syndrome patients had abnormal small-world properties. Centrality changes in the right pallidus and thalamus verified the important roles of these regions in the pathogenesis of Meige syndrome.

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Arching deep brain stimulation in dystonia types

Kim

Jeon

2021

J Neural Transm

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Subthalamic Nucleus Deep Brain Stimulation in Primary Meige Syndrome: A 1-Year Follow-Up Study

Cited by 16 publications

References 25 publications

Metabolic Imaging of Deep Brain Stimulation in Meige Syndrome

Metabolic Imaging of Deep Brain Stimulation in Meige Syndrome

Regional metabolic and network changes in Meige syndrome

Arching deep brain stimulation in dystonia types

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