Subthreshold Depression and Regional Brain Volumes in Young Community Adolescents

Vulser, Hélène; Lemaître, Hervé; Artiges, Éric; Miranda, Rubén; Penttilä, Jani; Struve, Maren; Fadai, Tahmine; Kappel, Viola; Grimmer, Yvonne; Goodman, Robert; Stringaris, Argyris; Poustka, Luise; Conrod, Patricia J.; Frouin, Vincent; Banaschewski, Tobias; Barker, Gareth J.; Bokde, Arun L.W.; Bromberg, Uli; Büchel, Christian; Flor, Herta; Gallinat, Juergen; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Lawrence, Claire; Loth, Eva; Mann, Karl; Nees, Frauke; Paus, Tomáš; Pausová, Zdenka; Rietschel, Marcella; Robbins, Trevor W.; Smolka, Michael N.; Schumann, Günter; Martinot, Jean Luc; Paillère-Martinot, M.L.; Dalley, Jeffrey W.; Subramaniam, Naresh; Theobald, David E.; Bach, Christiane; Fauth‐Bühler, Mira; Millenet, Sabina; Spanagel, Rainer; Albrecht, Lisa M.; Ivanov, Nikolay; Rapp, Michael A.; Reuter, Johanna; Strache, Nicole; Ströhle, Andreas; Lalanne, Christophe; Poline, J.-B.; Schwartz, Yannick; Thyreau, Benjamin; Lathrop, Mark; Ireland, James; Rogers, Jennifer L.; Bordas, N.; Bricaud, Zuleima; Filippi, Irina; Galinowski, A.; Gollier-Briant, Fanny; Massicotte, Jessica; Andrew, Chris; Cattrell, Anna; Desrivières, Sylvane; Hall, Daniel E.; Havatzias, S; Jia, Tianye; Mallik, Catherine; Nymberg, Charlotte; Reed, Laurence; Ruggeri, Barbara; Smith, Lance A.; Stueber, Kerstin; Topper, Lauren; Werts, Helen; Brühl, Rüdiger; Ihlenfeld, Albrecht; Walaszek, B.; Hübner, Thomas; Müller, Kathrin; Ripke, Stephan; Rodehacke, Sarah; Mennigen, Eva; Schmidt, Dirk; Vetter, Nora C.; Ziesch, Veronika; Carter, D.; Connolly, Colm G.; Nugent, Scott; Jones, Jennifer; Whelan, Robert; Yacubian, Juliana; Schneider, Sarah; Head, Kevin; Heym, Nadja; Newman, Craig; Tahmasebi, Amir M.; Stephens, David

doi:10.1016/j.jaac.2015.07.006

Cited by 53 publications

(46 citation statements)

References 45 publications

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“…The white matter is known as the main connecting structure responsible for signal transduction between different encephalic regions but is also the primary structure showing pathologic changes in major depression (Lyoo et al, ; Vulser et al, ). In previous qualitative and semiquantitative studies, Kumar et al () used magnetization transfer imaging and reported significantly lower magnetization ratios in the genu and splenium of the corpus callosum.…”

Section: Discussionmentioning

confidence: 99%

Exercise protects myelinated fibers of white matter in a rat model of depression

Xiao

Wang

Luo

et al. 2017

J of Comparative Neurology

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The antidepressive effects of exercise have been a focus of research and are hypothesized to remodel the brain networks constructed by myelinated fibers. However, whether the antidepressant effects of exercise are dependent on changes in white matter myelination are unknown. Therefore, we chose chronic unpredictable stress (CUS) as a model of depression and designed an experiment. After a 4-week CUS period, 40 animals were tested using the sucrose preference test (SPT) and the open field test (OFT). The depressed rats then underwent 4-week running exercise. Next, electron microscopy and unbiased stereological methods were used to investigate white matter changes in the rats. After the 4-week CUS stimulation, body weight, sucrose preference and scores on the OFT were significantly lower in the depression rats than in the unstressed rats (p < .05). After undergoing a 4-week running exercise, the depression rats showed a significantly greater sucrose preference than the depression control rats without running exercise (p < .05). Furthermore, the white matter parameters of the depression rats (including the white matter volumes, the length and volumes of myelinated fibers, and the volumes and thickness of the myelin sheaths) were significantly reduced after the CUS period (p < .05). However, these white matter parameters were significantly increased after running exercise (p < .05). The present study is the first to provide evidence that running exercise has positive effects on white matter and the myelinated fibers of white matter in depressed rats, and this evidence might provide an important theoretical basis for the exercise-mediated treatment of depression.

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Section: Discussionmentioning

confidence: 99%

Exercise protects myelinated fibers of white matter in a rat model of depression

Xiao

Wang

Luo

et al. 2017

J of Comparative Neurology

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“…Similarly, Hayakawa (Hayakawa et al, 2013) found decreased volume of the anterior cingulate gyrus in women with StD compared with healthy controls. The gray matter volume of the hippocampus, parahippocampus, ventromedial prefrontal cortex, cingulate cortex and caudate also showed negative correlations with StD severity (Vulser et al, 2015, Zhou et al, 2016). …”

Section: Introductionmentioning

confidence: 92%

Anatomical brain difference of subthreshold depression in young and middle-aged individuals

Wang

Hwang

et al. 2017

NeuroImage: Clinical

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BackgroundSubthreshold depression (StD) is associated with substantial functional impairments due to depressive symptoms that do not fully meet the diagnosis of major depressive disorder (MDD). Its high incidence in the general population and debilitating symptoms has recently put it at the forefront of mood disorder research.AimIn this study we investigated common volumetric brain changes in both young and middle-aged StD patients.MethodsTwo cohorts of StD patients, young and middle-aged, (n = 57) and matched controls (n = 76) underwent voxel-based morphometry (VBM).ResultsVBM analysis found that: 1) compared with healthy controls, StD patients showed decreased gray matter volume (GMV) in the bilateral globus pallidus and precentral gyrus, as well as increased GMV in the left thalamus and right rostral anterior cingulate cortex/medial prefrontal cortex; 2) there is a significant association between Center for Epidemiological Studies Depression Scale scores and the bilateral globus pallidus (negative) and left thalamus (positive); 3) there is no interaction between age (young vs. middle-age) and group (StD vs. controls).ConclusionsOur findings indicate significant VBM brain changes in both young and middle-aged individuals with StD. Individuals with StD, regardless of age, may share common neural characteristics.

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“…A few brain imaging studies on the neurobiology of subthreshold depression have been carried out recently. For example, a voxel-based morphometry (VBM) study revealed decreased gray matter volume in the right parahippocampal gyrus (PHG) in elderly individuals with subthreshold depression (Zhou et al, 2016); in addition, compared with controls, smaller gray matter volume in the frontolimbic circuits including the prefrontal, ACC, caudates and cingulum was found in adolescents with subthreshold depression (Vulser et al, 2015). These studies may partially indicate neural substrates related to structural alterations of subthreshold depression; however, the changes in FC between these brain regions with structural alterations remain unknown.…”

Section: Introductionmentioning

confidence: 99%

Decreased Subcortical and Increased Cortical Degree Centrality in a Nonclinical College Student Sample with Subclinical Depressive Symptoms: A Resting-State fMRI Study

Gao

Liu

et al. 2016

Front. Hum. Neurosci.

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Abnormal functional connectivity (FC) at rest has been identified in clinical depressive disorder. However, very few studies have been conducted to understand the underlying neural substrates of subclinical depression. The newly proposed centrality analysis approach has been increasingly used to explore the large-scale brain network of mental diseases. This study aimed to identify the degree centrality (DC) alteration of the brain network in subclinical depressive subjects. Thirty-seven candidates with subclinical depression and 34 well-matched healthy controls (HCs) were recruited from the same sample of college students. All subjects underwent a resting-state fMRI (rs-fMRI) scan to assess the DC of the whole brain. Compared with controls, subclinical depressive subjects displayed decreased DC in the right parahippocampal gyrus (PHG), left PHG/amygdala, and left caudate and elevated DC in the right posterior parietal lobule (PPL), left inferior frontal gyrus (IFG) and left middle frontal gyrus (MFG). In addition, by using receiver operating characteristic (ROC) analysis, we determined that the DC values in the regions with altered FC between the two groups can be used to differentiate subclinical depressive subjects from HCs. We suggest that decreased DC in subcortical and increased DC in cortical regions might be the neural substrates of subclinical depression.

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Subthreshold Depression and Regional Brain Volumes in Young Community Adolescents

Cited by 53 publications

References 45 publications

Exercise protects myelinated fibers of white matter in a rat model of depression

Exercise protects myelinated fibers of white matter in a rat model of depression

Anatomical brain difference of subthreshold depression in young and middle-aged individuals

Decreased Subcortical and Increased Cortical Degree Centrality in a Nonclinical College Student Sample with Subclinical Depressive Symptoms: A Resting-State fMRI Study

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