Subtle chemical modification for enrichment of Fmoc-amino acid at a phospholipid interface

Abstract

A modest chemical modification of the Fmoc-amino acids led to enhanced interaction with a model surface for biomembrane.

Bioinspired Amino Acid Based Materials in Bionanotechnology: From Minimalistic Building Blocks and Assembly Mechanism to Applications

“…Gour et al reported the self-assembly of the nonaromatic amino acids cysteine (Cys) and methionine (Met) into amyloid-like fibrils in neutral water . The formation of amyloid-like assembled structures was verified by binding assays of Thioflavin T (ThT) and Congo red (CR) as ThT exhibited significant fluorescence enhancement, while CR showed increased red-shifted light absorption intensity upon binding to the amyloid structures. , In addition, amino acids could self-assemble into 3D gels through molecular modification. ,− Typically, Fmoc-modified amino acids are able to trap solvent molecules to form hydrogels. ,− Among these, as a leading hydrogel promoter, Fmoc-Phe has excellent assembly capabilities and could self-assemble into efficient, stable, and transparent hydrogels with a minimum gelation concentration of 0.1% w/v. Hydrogels with 3D structures act as templates to complex with silver ions (Ag + ) and induce the formation of silver nanoclusters in the presence of diffuse sunlight at pH 7.46 and room temperature .…”