Subtotal Excision With Adjunctive Sclerosing Therapy for the Treatment of Severe Symptomatic Orbital Lymphangiomas

Kahana, Alon

doi:10.1001/archophthalmol.2011.204

Cited by 17 publications

(12 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…173 The efficacy of other sclerosants including sodium tetradecyl sulphate (Sotradecol) 136,198 and sodium morrhuate have been studied. 78,162 These agents cause fibrosis and vascular obliteration by intimal inflammation and thrombus formation. There is concern regarding the use of these traditional sclerosants (e.g., sodium tetradecyl sulfate) in the deep orbit because they might be associated with significant swelling, increased mass effect, and intraorbital pressure.…”

Section: Nonsurgical Managementmentioning

confidence: 99%

“…Kahana et al described a subtotal excision with adjunctive sclerosing therapy for the treatment of severe symptomatic orbital lymphaticovenous malformations. 78 In their technique, cycles of dissection, injection of sodium morrhuate, and excision were repeated until most of the tumor bulk was removed or extinguished. 78 One of the concerns about large, deep lesions is excessive bleeding that can occur during excision or debulking of the lesions.…”

Section: Surgical Managementmentioning

confidence: 99%

“…78 In their technique, cycles of dissection, injection of sodium morrhuate, and excision were repeated until most of the tumor bulk was removed or extinguished. 78 One of the concerns about large, deep lesions is excessive bleeding that can occur during excision or debulking of the lesions. Some authors have reported intralesional injection of liquid polymers (e.g., cyanoacrylate glue, fibrin glue) into the friable cystic or the deep venous components.…”

Section: Surgical Managementmentioning

confidence: 99%

See 2 more Smart Citations

Orbital lymphaticovenous malformations: Current and future treatments

Nassiri

Rootman

et al. 2015

Survey of Ophthalmology

101

View full text Add to dashboard Cite

Section: Nonsurgical Managementmentioning

confidence: 99%

Section: Surgical Managementmentioning

confidence: 99%

Section: Surgical Managementmentioning

confidence: 99%

See 1 more Smart Citation

Orbital lymphaticovenous malformations: Current and future treatments

Nassiri

Rootman

et al. 2015

Survey of Ophthalmology

101

View full text Add to dashboard Cite

“…These include neurofibromatosis type 1, 12 Klippel-Trenaunay syndrome, 13 and tuberous sclerosis complex. 14 Orbital lymphangioma was related in association with persistent fetal vasculature 15 and retinal and iris malformations, 16 among other vascular system abnormalities.…”

Section: Discussionmentioning

confidence: 99%

Orbital Lymphangioma: Case Report and Management Paradigms

et al. 2017

View full text Add to dashboard Cite

Introduction Lymphangioma is a rare congenital vascular malformation of the head and neck region isolated from the systemic circulation. It has a benign etiology, and represents 1-3% of all orbital tumors. These hamartomas often present in the pediatric population with a slightly female predilection. They have a lymphocytic composition, and may increase in size with episodes of viral infection, causing proptosis. Discussion The management of this lesion is controversial, hardly curative, and depends on the clinical presentation. The treatment options include partial surgical resection of the major cyst, needle aspiration, surgical debulking, systemic steroids, sildenafil, intralesional injection of the sclerosing agents, and local radiotherapy. Case Report In the present report, we describe an uncommon case of lymphangioma in a 6-year-old female who was first submitted to neurosurgery for tumor resection and received sildenafil therapy later, with promising results. Conclusion The treatment of orbital lymphangiomas remains a controversial topic, and the use of sildenafil along with needle aspiration and microsurgical removal is a viable option of treatment. However, many issues, such as the ideal duration of the therapy, the dosage regimen and the recurrence rate, still remain unclear. Our case report adds promising data on this pathology, even though larger trials are needed to properly elucidate the remaining questions.

show abstract

“…One study reported that incomplete excision with intraoperative adjuvant injection of 5% sodium morrhuate resulted in phlebosclerosis in orbital lymphatic malformations [15]. This study was limited by the lack of a control group that did not receive the adjuvant sclerotherapy.…”

Section: Discussionmentioning

confidence: 99%