Subventricular zone predicts high velocity of tumor expansion and poor clinical outcome in patients with low grade astrocytoma

Wen, Bing; Fu, Feixian; Hu, Liangbo; Cai, Qing-Qing; Xie, Jia

doi:10.1016/j.clineuro.2018.02.036

Cited by 8 publications

(14 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, contact with the SGZ does not seem to influence survival [48]. For low-grade astrocytoma, it has been reported that anatomical involvement of the SVZ might predict poor survival [49,50]. Still, due to cell migration it is possible that the origin of gliomas is not related to the center of maximum tumor load.…”

Section: Discussionmentioning

confidence: 99%

Is the anatomical distribution of low-grade gliomas linked to regions of gliogenesis?

et al. 2020

View full text Add to dashboard Cite

Introduction According to the stem cell theory, two neurogenic niches in the adult human brain may harbor cells that initiate the formation of gliomas: The larger subventricular zone (SVZ) and the subgranular zone (SGZ) in the hippocampus. We wanted to explore whether defining molecular markers in low-grade gliomas (LGG; WHO grade II) are related to distance to the neurogenic niches. Methods Patients treated at two Norwegian university hospitals with population-based referral were included. Eligible patients had histopathological verified supratentorial low-grade glioma. IDH mutational status and 1p19q co-deletion status was retrospectively assessed. 159 patients were included, and semi-automatic tumor segmentation was done from pretreatment T2-weighted (T2W) or Fluid-Attenuated Inversion Recovery (FLAIR) images. 3D maps showing the anatomical distribution of the tumors were then created for each of the three molecular subtypes (IDH mutated/1p19q co-deleted, IDH mutated and IDH wild-type). Both distance from tumor center and tumor border to the neurogenic niches were recorded. Results In this population-based cohort of previously untreated low-grade gliomas, we found that low-grade gliomas are more often found closer to the SVZ than the SGZ, but IDH wild-type tumors are more often found near SGZ. Conclusion Our study suggests that the stem cell origin of IDH wild-type and IDH mutated low-grade gliomas may be different.

show abstract

Section: Discussionmentioning

confidence: 99%

Is the anatomical distribution of low-grade gliomas linked to regions of gliogenesis?

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In our study, 44 of 77 patients with nSVZE had unfavorable survival outcome. Previous studies have shown there is a correlation between preoperative invasion at the subventricular zone and the unfavorable outcome of grade IV gliomas, suggesting an unfavorable impaction of invasion at the subventricular zone on PFS and OS [16][17][18]. e subventricular zone, which is believed as a pool of stem cells and is within 5 mm to the ventricular wall, may be a structure that the brain tumor stem cells would be derived from [5].…”

Section: Discussionmentioning

confidence: 99%

New Enhancement beyond Radiation Field Improves Survival Prediction in Patients with Post-Treatment High-Grade Glioma

Tao

Liu

et al. 2021

Journal of Oncology

View full text Add to dashboard Cite

The imaging signs which can accurately predict survival prognosis after standard treatment of high-grade glioma (HGG) are highly desirable. This study aims to explore the role of new enhancement beyond radiation field (NERF) in the survival prediction in patients with post-treatment HGG. The present study included 142 pathologically confirmed HGG patients who had received standard treatment. NERF, as well as other conventional MR findings and clinical variables, were included in univariate and multivariate analyses for evaluating their impactions on progression-free survival (PFS) and overall survival (OS). Univariate analysis showed that histological grade ( p = 0.008 ) and NERF ( p = 0.001 ) were the prognostic variables for poor PFS, whereas histological grade ( p = 0.017 ), NERF ( p = 0.001 ), and new subventricular zone enhancement (nSVZE) ( p = 0.001 ) were prognostic variables for poor OS. The multivariate analysis showed that NERF (HR 3.93; 95% CI 1.93–8.01; p = 0.001 ) and nSVZE (HR 3.92; 95% CI 1.95–7.89; p = 0.001 ) were the prognostic variables for poor OS. However, only nSVZE was (HR 3.29; 95% CI 2.04–5.28; p = 0.001 ) the prognostic variable for poor PFS. When combining the NERF with the clinical and other MR variables, the highest AUC (0.924) and specificity (0.899) for predicting poor OS were achieved. The location of new developed enhancements relevant to high dose radiation field appears to be the main determinant of their prognostic value. Our results suggest that the new enhancement beyond radiation field can improve the survival prediction in patients with HGG after standard treatment.

show abstract

“…A few papers have investigated whether SVZ involvement is also a poor prognostic indicator in lower grade gliomas (LGG). Both SVZ involvement and a shorter distance between the tumor margin and the SVZ were found to be associated with more rapid growth and worse prognosis in grade II and III astrocytomas 7‐9 . Furthermore, involvement of the occipital portion of the SVZ was associated with worse prognosis in grade III astrocytomas 9 …”

Section: Introductionmentioning

confidence: 99%

“…Both SVZ involvement and a shorter distance between the tumor margin and the SVZ were found to be associated with more rapid growth and worse prognosis in grade II and III astrocytomas. [7][8][9] Furthermore, involvement of the occipital portion of the SVZ was associated with worse prognosis in grade III astrocytomas. 9 Recently, tumor genetics has assumed a major role in glioma prognostication, 10,11 particularly mutations in isocitrate dehydrogenase (IDH1 or IDH2), which are found in more than 70% of LGGs.…”

Section: Introductionmentioning

confidence: 99%

The Prognostic Value of MRI Subventricular Zone Involvement and Tumor Genetics in Lower Grade Gliomas

Chiang

Pisapia

Liechty

et al. 2020

Journal of Neuroimaging

View full text Add to dashboard Cite

BACKGROUND AND PURPOSE: Glioblastomas (GBMs) that involve the subventricular zone (SVZ) have a poor prognosis, possibly due to recruitment of neural stem cells. The purpose of this study was to evaluate whether SVZ involvement by lower grade gliomas (LGG), WHO grade II and III, similarly predicts poorer outcomes. We further assessed whether tumor genetics and cellularity are associated with SVZ involvement and outcomes. METHODS: Forty-five consecutive LGG patients with preoperative imaging and next generation sequencing were included in this study. Regional SVZ involvement and whole tumor apparent diffusion coefficient (ADC) values, as a measure of cellularity, were assessed on magnetic resonance imaging. Progression was determined by RANO criteria. Kaplan-Meier curves and Cox regression analyses were used to determine the hazard ratios (HR) for progression and survival. RESULTS: Frontal, parietal, temporal, and overall SVZ involvement and ADC values were not associated with progression or survival (P ≥ .05). However, occipital SVZ involvement, seen in two patients, was associated with a higher risk of tumor progression (HR = 6.6, P = .016) and death (HR = 31.5, P = .015), CDKN2A/B mutations (P = .03), and lower ADC histogram values at the 5th (P = .026) and 10th percentiles (P = .046). Isocitrate dehydrogenase, phosphatase and tensin homolog, epidermal growth factor receptor, and cyclin-dependent kinase 4 mutations were also prognostic (P ≤ .05). CONCLUSIONS: Unlike in GBM, overall SVZ involvement was not found to strongly predict poor prognosis in LGGs. However, occipital SVZ involvement, though uncommon, was prognostic and found to be associated with CDKN2A/B mutations and tumor hypercellularity. Further investigation into these molecular mechanisms underlying occipital SVZ involvement in larger cohorts is warranted.

show abstract

Subventricular zone predicts high velocity of tumor expansion and poor clinical outcome in patients with low grade astrocytoma

Cited by 8 publications

References 21 publications

Is the anatomical distribution of low-grade gliomas linked to regions of gliogenesis?

Is the anatomical distribution of low-grade gliomas linked to regions of gliogenesis?

New Enhancement beyond Radiation Field Improves Survival Prediction in Patients with Post-Treatment High-Grade Glioma

The Prognostic Value of MRI Subventricular Zone Involvement and Tumor Genetics in Lower Grade Gliomas

Contact Info

Product

Resources

About