Successful in vitro fertilization with anonymous donor oocytes in a patient with recurrent massive hemoperitoneum following spontaneous and induced ovulation

Brabec, Celeste; Vogt, Margaret A.; Wilson, J. Frank; Lyles, R.

doi:10.1016/s0015-0282(01)03277-0

Cited by 2 publications

(3 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bleeding often recurred and required transfusion in the majority of cases [4]. Massive hemoperitoneum due to rupture of a hemorrhagic corpus luteum is an uncommon but serious complication of vWD [40][41][42][43][44][45]. Patients present with severe midcycle abdominal pain, hypotension, and profound anemia, often requiring surgical exploration and aggressive bloodproduct replacement.…”

Section: Other Gynecological Bleedingmentioning

confidence: 99%

“…Patients present with severe midcycle abdominal pain, hypotension, and profound anemia, often requiring surgical exploration and aggressive bloodproduct replacement. Hemoperitoneum preceded the diagnosis of vWD in several cases and often recurred during subsequent cycles [40][41][42]44].…”

Section: Other Gynecological Bleedingmentioning

confidence: 99%

“…It is unknown whether the particular composition and estrogen dose affect their efficacy for vWD-associated menorrhagia. Oral contraceptives are also used to suppress ovulation and prevent recurrent hemoperitoneum in women with vWD [40][41][42]44].…”

Section: Oral Contraceptivesmentioning

confidence: 99%

See 2 more Smart Citations

von Willebrand's disease and menorrhagia: Prevalence, diagnosis, and management

Kujovich¹

2005

American J Hematol

View full text Add to dashboard Cite

The reported prevalence of von Willebrand's disease (vWD) is increased in women with menorrhagia, with current estimates ranging from 5% to 20%. The consistent results of multiple studies suggest testing should be included in the evaluation of patients with menorrhagia, especially in unexplained cases and prior to surgical intervention. Although a cyclic variation in von Willebrand's factor levels has not been confirmed, several studies suggest lower levels during menses and the early follicular phase. Menorrhagia is one of the most common bleeding manifestations of von Willebrand's disease, reported by 60-95% of women afflicted with this bleeding disorder. Menorrhagia is typically severe, often resulting in anemia and interfering with quality of life. Despite the frequency of menorrhagia, there is no consensus on optimal management. Although oral contraceptives are frequently prescribed, there are no studies confirming their efficacy using objective measures of response. Desmopressin was associated with an 80-92% response rate in several uncontrolled studies relying on patient assessment of efficacy. However, a small, randomized trial found no significant reduction in menstrual blood flow compared with placebo. There are anecdotal reports of the successful use of antifibrinolytic agents alone and in combination with other therapies. There are no studies comparing the relative efficacy and safety of the available medical therapies for von Willebrand's disease associated menorrhagia. Until these studies are completed, treatment should be individualized based on von Willebrand's disease subtype, patient age, contraceptive needs, and personal preference. Am.

show abstract