Successful long-term thalidomide therapy for discoid lupus erythematosus-lichen planus overlap syndrome

Zhang, Lisa; Au, Sonoa; Aronson, Iris K.

doi:10.5070/d32010024267

Cited by 4 publications

(1 citation statement)

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“…The symptoms of the patient were controlled well after adding acitretin and immunosuppressive medicines. Effective treatments for LP/LE overlap syndrome include glucocorticoids combined with hydroxychloroquine, acitretin, thalidomide, cyclosporin, methotrexate, local tacrolimus, and corticosteroids (15)(16)(17).…”

Section: Discussionmentioning

confidence: 99%

Case Report: The First Reported Case of Bullous Lichen Planus-Systemic Lupus Erythematosus Overlap Syndrome

Liu

Liang

et al. 2021

Front. Med.

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Introduction: Lichen planus/lupus erythematosus overlap syndrome is rarely seen in the clinic and has the characteristic clinical manifestations, histopathology, and immunopathology of lichen planus (LP) and lupus erythematosus (LE). This is the first reported case of bullous lichen planus (BLP)/systemic lupus erythematosus (SLE) overlap syndrome with hair loss as the first symptom.Case Presentation: A 48-year-old female presented with alopecia for half a year, and skin lesions accompanied by itching on her face, trunk, and limbs for 3 months. She had a history suggestive of photosensitivity. Laboratory tests and histopathology were performed for diagnosis. Histopathologic features of the upper arm and back of the hand were consistent with BLP, whereas the scalp lesion indicated LE. Laboratory examination indicated positive for antinuclear antibody (ANA) (1:160), leukopenia, increased urinary protein, decreased C3/C4, and normal BP180. The patient was given glucocorticoid combined with acitretin and immunosuppressive therapy after a definite diagnosis of BLP/SLE overlap syndrome. The lesions of the patient disappeared and some hair had regrown during the two years of follow-up.Conclusion: This is the first reported case of BLP/SLE overlap syndrome which responded well to glucocorticoids, retinoids, and immunosuppressive drugs. Multiple biopsies from characteristic lesions will guide doctors to avoid misdiagnoses and delayed treatment.

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Section: Discussionmentioning

confidence: 99%