Successful percutaneous CT-guided microwave ablation of adrenal gland for ectopic Cushing syndrome

Zener, Rebecca; Zaleski, Andrew; Uum, Stan H. Van; Gray, Daryl; Mujoomdar, Amol

doi:10.1016/j.clinimag.2016.11.021

Cited by 11 publications

(7 citation statements)

References 12 publications

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“…In recent years, several radio-wave medical imaging and therapeutic systems have been developed, with radio-wave ablation being one of the most notable development to treat cancerous lesions in the human body. Radio-wave thermal ablation has been investigated for minimally invasive treatment of adrenal adenomas [11][12]. The development of ablative therapy for adrenal adenomas require accurate knowledge of dielectric properties of the adrenal gland.…”

Section: Introductionmentioning

confidence: 99%

Broadband dielectric properties of adrenal gland for accurate anatomical modelling in medical applications

Shahzad

Clausing

Prakash

et al. 2017

2017 International Conference on Electromagnetics in Advanced Applications (ICEAA)

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− Dielectric properties of biological tissue are important in safety assessment and evaluation of novel medical imaging and therapeutic devices. This paper reports frequency dependent dielectric properties of adrenal tissue, which is a potential target for microwave ablative therapy to treat benign and malignant adrenal tumors. Dielectric properties of bovine adrenal glands were measured using open-ended coaxial probe over 0.5 to 20 GHz, and a two pole Cole-Cole model was fitted to the measured data. The parameters of Cole-Cole model are presented in this paper.

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Section: Introductionmentioning

confidence: 99%

Broadband dielectric properties of adrenal gland for accurate anatomical modelling in medical applications

Shahzad

Clausing

Prakash

et al. 2017

2017 International Conference on Electromagnetics in Advanced Applications (ICEAA)

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“…RFA of adrenal glands in tumor treatment has been reported on widely, [ 5 - 10 ] and multiple publications describe ablation of functioning adrenal tumors. [ 11 - 15 ] In turn, the few published reports on microwave adrenal ablation in ectopic Cushing syndrome [ 3 , 4 , 16 ] note a significant decrease in serum cortisol levels, although with follow-up periods only between a week and 5 months in length. Sarma et al .…”

Section: Discussionmentioning

confidence: 99%

“…However, the follow-up period was again a relatively short one (at 2–3 months). A second report [ 3 ] presented a patient with ectopic Cushing syndrome treated by way of right adrenal microwave ablation. Before this, the patient had had pancreatic tumor resection, as well as a splenectomy, left adrenalectomy, and left nephrectomy.…”

Section: Discussionmentioning

confidence: 99%

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Percutaneous Bilateral Adrenal Radiofrequency Ablation in Severe Adrenocorticotropic Hormone-dependent Cushing Syndrome

Rosiak

Milczarek

Konecki

et al. 2020

JCIS

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Objectives: The objectives of the study were to evaluate adrenal radiofrequency ablation (RFA) as a method of treatment in patients with severe adrenocorticotropic hormone (ACTH)-dependent Cushing syndrome, among whom bilateral adrenalectomy is not a suitable option. Material and Methods: Five patients with ACTH-dependent Cushing syndrome underwent RFA of both adrenal glands. Four of them presented with Cushing disease unsuccessfully treated with pituitary surgery and medical therapy, while one patient had ACTH-dependent Cushing syndrome due to pancreatic endocrine tumor with liver metastases. All patients were disqualified from adrenalectomy due to morbid obesity or lack of consent. Results: A technical success was obtained in all cases, with only one re-intervention necessitated by a cooling effect of the inferior vena cava. Despite pre-procedural adrenergic blockade, severe hypertension was noted during the procedure in three cases, this being treated immediately using direct-acting vasodilators. No complications occurred otherwise. In all cases, significant improvement of clinical symptoms was observed, as well as marked decreases in levels of serum cortisol, free urine cortisol, and dehydroepiandrosterone sulfate. Conclusion: Bilateral RFA under CT-guidance is technically feasible and clinical improvement can be achieved using the method. In patients disqualified from adrenal surgery, RFA might be considered as an alternative method of ACTH-dependent Cushing syndrome treatment.

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“…It offers higher tissue temperature, larger ablation volume, faster ablation times, and less heat-sink effect compared to RFA [72][73][74][75][76]. Recently, MWA has been used to treat adrenal benign and metastatic tumors [77][78][79][80][81][82] as well as liver, kidney, and lung tumors. The outcomes of this ablation technique have been reported to be excellent although long-term follow-up data are not still available [77][78][79][80][81][82].…”

Section: Microwave Ablationmentioning

confidence: 99%

Asian Conference on Tumor Ablation Guidelines for Adrenal Tumor Ablation

et al. 2021

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Thermal ablation is a good alternative treatment in patients who are unable to undergo adrenalectomy. Even though the Asian Conference on Tumor Ablation (ACTA) has been held for many years, adrenal ablation guidelines have not been established. No guidelines for adrenal ablation are established in American and European countries, either. The aim of this review was to introduce the first version of ACTA guidelines for adrenal tumor ablation.

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Successful percutaneous CT-guided microwave ablation of adrenal gland for ectopic Cushing syndrome

Cited by 11 publications

References 12 publications

Broadband dielectric properties of adrenal gland for accurate anatomical modelling in medical applications

Broadband dielectric properties of adrenal gland for accurate anatomical modelling in medical applications

Percutaneous Bilateral Adrenal Radiofrequency Ablation in Severe Adrenocorticotropic Hormone-dependent Cushing Syndrome

Asian Conference on Tumor Ablation Guidelines for Adrenal Tumor Ablation

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