Successful pregnancy after spontaneous remission of familial pulmonary alveolar proteinosis

Canto, M. J.; Vives, Marian; Carmona, Francisco; Agustı́, Carles; Cararach, V.; Iglesias, Xavier

doi:10.1016/0301-2115(95)02237-6

Cited by 7 publications

(3 citation statements)

References 8 publications

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“…The indication of therapy must be considered by a multidisciplinary team including internal medicine specialists, anesthesiologists, obstetricians, fetal medicine specialists, and neonatologists. So far in the literature, there are few cases of WLL in pregnancy described, and mainly before 34 weeks gestation, as shown in Table 3 [ 12 , 13 , 14 , 15 ]. Among those cases, all but one experienced the exacerbation of the disease during pregnancy [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Alveolar Proteinosis and Pregnancy: A Review of the Literature and Case Presentation

et al. 2022

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Pulmonary Alveolar Proteinosis (PAP) is a rare, usually autoimmune, disease, where surfactant accumulates within alveoli due to decreased clearance, causing dyspnea and hypoxemia. The disease is even more rare in pregnancy; nevertheless, it has been reported in pregnant women and can even appear for the first time during pregnancy as an asthma-like illness. Therefore, awareness is important. Similarly to many autoimmune diseases, it can worsen during pregnancy and postpartum, causing maternal and fetal/neonatal complications. This paper offers a narrative literature review of PAP and pregnancy, while illustrating a case of a pregnant patient with known PAP who developed preeclampsia in the third trimester but had an overall fortunate maternal and neonatal outcome.

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Section: Discussionmentioning

confidence: 99%

Pulmonary Alveolar Proteinosis and Pregnancy: A Review of the Literature and Case Presentation

et al. 2022

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“…There are only few case reports describing PAP during pregnancy. [59606162] Its presence may lead to perinatal or postnatal complications. [59606162] Whether physiologic changes in pregnancy or alteration in levels of various growth factors predispose to PAP is not known.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary alveolar proteinosis: Experience from a tertiary care center and systematic review of Indian literature

et al. 2016

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Background:Pulmonary alveolar proteinosis (PAP) is a rare disorder characterized by deposition of lipoproteinaceous material within alveoli, with a variable clinical course. Here, we report an experience of management of PAP at our center. A systematic review of previously reported cases from India is also included in the article.Materials and Methods:This study included patients with primary PAP managed at our center from 2009 to 2015. Diagnosis of primary PAP was based on histopathologic diagnosis on bronchoalveolar lavage or transbronchial lung biopsy and absence of causes of secondary PAP. For systematic review of Indian publications, the literature search was performed using PubMed and EMBASE databases using the terms “pulmonary alveolar proteinosis'” or “alveolar proteinosis” and “India” or “Indian.”Results:During the above-specified period, five patients with diagnosis of PAP were admitted at our center. Median age of patients was 32 years (interquartile range [IQR] 30.5–59); 80% were female. Mean duration (± standard deviation) of symptoms was 6.2 (±1.79) months. Anti-granulocyte-macrophage colony stimulating factor (GM-CSF) antibodies were elevated in 4 out of 5 patients (80%). For management, whole lung lavage (WLL) was done for four patients with median volume of 32.5 (IQR 18–74) L per patient. All the patients showed significant symptomatic as well as improvement in physiological parameters. Subcutaneous GM-CSF and ambroxol were given to 3 patients and 1 patient, respectively. The median follow-up of all patients was 18 (IQR 5–44) months. A systematic review of all Indian studies of PAP revealed thirty publications.Conclusions:WLL is the most common, effective, and safe therapy in patients with PAP. GM-CSF administration is an efficacious treatment for patients with incomplete response after WLL.

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“…En la serie de Goldstein, el 46% de los pacientes no requerían lavado pulmonar completo (LPC) en el tiempo de seguimiento (8). Por otra parte, se han publicado casos de remisión espontánea sin tratamiento (10,15,16). De ser necesario algún tratamiento el LPC es el más seguro y efectivo (1), siendo la administración de GM-CSF una alternativa en casos seleccionados (17,18).…”

Section: Discussionunclassified

Proteinosis alveolar, un hallazgo incidental en un estudio preoperatorio con respuesta insuficiente al lavado pulmonar completo

González‐Barcala

Blanco-González

Valdés-Cuadrado

et al. 2003

An. Med. Interna (Madrid)

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Successful pregnancy after spontaneous remission of familial pulmonary alveolar proteinosis

Cited by 7 publications

References 8 publications

Pulmonary Alveolar Proteinosis and Pregnancy: A Review of the Literature and Case Presentation

Pulmonary Alveolar Proteinosis and Pregnancy: A Review of the Literature and Case Presentation

Pulmonary alveolar proteinosis: Experience from a tertiary care center and systematic review of Indian literature

Proteinosis alveolar, un hallazgo incidental en un estudio preoperatorio con respuesta insuficiente al lavado pulmonar completo

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