Successful pregnancy occurring with interferon‐alpha therapy in chronic myeloid leukemia

Successful pregnancies in patients with BCR‐ABL‐positive leukemias treated with interferon‐alpha therapy during the tyrosine kinase inhibitors era

“…Several case reports have been documented. 9,11,16,[30][31][32][33][34][35][36][37][38][39][40][41][42][43] This review of the 22 reported IFN-alpha exposures in pregnancy confirms our results and did not identify any published report of major malformations (only one case with fetal growth retardation and oligohydramnios). All pregnancies resulted in healthy babies and favorable maternal outcome.…”

CML in pregnancy: A case report using leukapheresis and literature review

“…One study reported using interferon alpha in 27 infants born to 26 mothers, demonstrated no fetal malformations other than premature deliveries and intrauterine growth retardation but it was unclear whether the later was related to interferon alpha [22][23][24][25]. Hydroxyurea is another option to treat CML in pregnancy and appears to be safe as reported previously [26].…”

A Case of Chronic Myelogenous Leukemia in Pregnancy Characterized by a Complex Translocation t(9;22;11)(q34;q11.2;q13)

“…The incidence of CML in pregnancy is 1–2 per 100,000 pregnancies/year. 3,4 Although most patients carry the t(9;22) translocation, atypical translocations are found in approximately 5–8% of cases. 5,6 It is plausible that those variations could affect the course of the disease by altering the structure of the tyrosine kinase ligand binding site.…”

“…9 Successful pregnancies have been reported with close observation, leuka-pheresis, hydroxyurea, IFN-α, and tyrosine kinase inhibitors. 3,4,18–29 …”

“…It does not inhibit DNA synthesis directly and it crosses the placenta to a minimal extent 4,29,32 Many references describe administration of IFN-α during pregnancy. 4,22,29,32,34,35 All pregnancies resulted in healthy babies without congenital abnormalities. Interferon is relatively safe in pregnancy and could be considered a drug of choice.…”