Successful Revascularization has a Significant Impact on Limb Salvage Rate and Wound Healing for Patients with Diabetic Foot Ulcers: Single-Centre Retrospective Analysis with a Multidisciplinary Approach

Caetano, António; Vasco, Inês Conde; Gomes, Filipe Veloso; Costa, Nuno Vasco; Luz, José Hugo Mendes; Spaepen, Erik; Formiga, Ana; Coimbra, Élia; Neves, José; Bilhim, Tiago

doi:10.1007/s00270-020-02604-4

Cited by 21 publications

(7 citation statements)

References 15 publications

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“…Similarly, a retrospective comparison of patients with Charcot foot found a high prevalence of PAD, which was predicted by the presence of DFUs [ 31 ]. There are many revascularization techniques that have shown that reperfusion of the ulcer area in eligible patients decreases amputation risk and death [ 32 , 33 , 34 ]. One method to evaluate the benefit of revascularization for the treatment of PAD in diabetic patients is with the wound, ischemia, and foot infection (WIFI) classification system developed by the Society for Vascular Surgery.…”

Section: Pathophysiology Associated With Diabetic Wound Healingmentioning

confidence: 99%

Diabetic Wound-Healing Science

et al. 2021

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Diabetes mellitus is an increasingly prevalent chronic metabolic disease characterized by prolonged hyperglycemia that leads to long-term health consequences. It is estimated that impaired healing of diabetic wounds affects approximately 25% of all patients with diabetes mellitus, often resulting in lower limb amputation, with subsequent high economic and psychosocial costs. The hyperglycemic environment promotes the formation of biofilms and makes diabetic wounds difficult to treat. In this review, we present updates regarding recent advances in our understanding of the pathophysiology of diabetic wounds focusing on impaired angiogenesis, neuropathy, sub-optimal chronic inflammatory response, barrier disruption, and subsequent polymicrobial infection, followed by current and future treatment strategies designed to tackle the various pathologies associated with diabetic wounds. Given the alarming increase in the prevalence of diabetes, and subsequently diabetic wounds, it is imperative that future treatment strategies target multiple causes of impaired healing in diabetic wounds.

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Section: Pathophysiology Associated With Diabetic Wound Healingmentioning

confidence: 99%

Diabetic Wound-Healing Science

et al. 2021

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“… 43 Once a PAD referral has been made, vascular surgeons can use the ML algorithm in addition to their clinical judgment to identify those at higher risk of adverse limb events who may be considered for (1) additional vascular imaging to delineate anatomy and disease severity, 44 (2) medical management with low-dose rivaroxaban, 45 and/or (3) interventions for limb salvage in the highest risk patients. 46 , 47 Overall, our automated ML tool can improve care for PAD patients in several ways in both the generalist and specialist settings, including providing efficient PAD screening and stratification of risk, supporting early identification and treatment of patients at high risk for adverse limb events, and reducing the number of unneeded specialist referrals, ultimately improving PAD outcomes and reducing health care costs. 48 …”

Section: Discussionmentioning

confidence: 99%

A machine learning algorithm for peripheral artery disease prognosis using biomarker data

Li,

Shaikh,

Zamzam

et al. 2024

iScience

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“…For example, a study from the United States suggested that many patients do not even receive angiography in the year before major limb amputation [ 37 ]. In the last two decades, improved awareness of the need for limb preservation has given rise to the idea of integrated amputation prevention programs in which specialized multidisciplinary teams cooperate in the medical/surgical management of these patients [ 38 , 39 ]. In the new GVG, the importance of multidisciplinary teams (MDT) and centres of excellence for amputation prevention are stressed as a key health system initiative [ 4 ].…”

Section: The Need For Fast-track Team-based Management For Optimal Cl...mentioning

confidence: 99%

Limb Salvage and Survival in Chronic Limb-Threatening Ischemia: The Need for a Fast-Track Team-Based Approach

Ventoruzzo,

Mazzitelli,

Ruzzi

et al. 2023

JCM

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Chronic limb-threatening ischemia (CLTI) represents the end-stage form of peripheral arterial disease (PAD) and is associated with a very poor prognosis and high risk of limb loss and mortality. It can be considered very similar to a terminal cancer disease, reflecting a large impact on quality of life and healthcare costs. The aim of this study is to offer an overview of the relationship between CLTI, limb salvage, and mortality, with a focus on the need of a fast-track team-based management that is a driver to achieve better survival results. This review can be useful to improve management of this growing impact disease, and to promote the standardisation of care and communication between specialist and non-specialist healthcare professionals.

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Successful Revascularization has a Significant Impact on Limb Salvage Rate and Wound Healing for Patients with Diabetic Foot Ulcers: Single-Centre Retrospective Analysis with a Multidisciplinary Approach

Cited by 21 publications

References 15 publications

Diabetic Wound-Healing Science

Diabetic Wound-Healing Science

A machine learning algorithm for peripheral artery disease prognosis using biomarker data

Limb Salvage and Survival in Chronic Limb-Threatening Ischemia: The Need for a Fast-Track Team-Based Approach

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