Successful Treatment of Refractory Enteropathy-Associated T-Cell Lymphoma Using High-Dose Chemotherapy and Autologous Stem Cell Transplantation

Ikebe, Taichi; Miyazaki, Yasuhiko; Abe, Yui; Urakami, Kuniko; Ohtsuka, Eiichi; Saburi, Yoshio; Saburi, Masuho; Ando, Tadasuke; Kohno, Kazuhiro; Ogata, Masao; Kadota, Jun‐ichi

doi:10.2169/internalmedicine.49.3409

Cited by 8 publications

(2 citation statements)

References 19 publications

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“…Surgery, chemotherapy and radiotherapy are all used to treat MEITL, although these treatments have shown poor overall outcomes[ 21 ]. Although several studies have demonstrated the benefit of autologous stem cell transplantation[ 22 - 25 ], there is no standardized treatment strategy. Moreover, MEITL often requires emergency surgery due to intestinal perforation or obstruction, and the lesion has usually spread before it is diagnosed[ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Monomorphic epitheliotropic intestinal T-cell lymphoma presenting as melena with long-term survival: A case report and review of literature

Ozaka

Inoue

Okajima

et al. 2021

WJG

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BACKGROUND Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a rare primary intestinal T-cell lymphoma, previously known as enteropathy-associated T-cell lymphoma type II. MEITL is an aggressive T-cell lymphoma with a poor prognosis and high mortality rate. The known major complications of MEITL are intestinal perforation and obstruction. Here, we present a case of MEITL that was diagnosed following upper gastrointestinal bleeding from an ulcerative duodenal lesion, with recurrence-free survival for 5 years. CASE SUMMARY A 68-year-old female was admitted to our hospital with melena and mild anemia. An urgent esophagogastroduodenoscopy (EGD) revealed bleeding from an ulcerative lesion in the transverse part of the duodenum, for which hemostatic treatment was performed. MEITL was diagnosed following repeated biopsies of the lesion, and cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy was administered. She achieved complete remission after eight full cycles of CHOP therapy. At the last follow-up examination, EGD revealed a scarred ulcer and 18 Fluorodeoxyglucose ( 18 FDG) positron emission tomography/computed tomography showed no abnormal FDG accumulation. The patient has been in complete remission for 68 mo after initial diagnosis. CONCLUSION To rule out MEITL, it is important to carefully perform histological examination when bleeding from a duodenal ulcer is observed.

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Section: Discussionmentioning

confidence: 99%

Monomorphic epitheliotropic intestinal T-cell lymphoma presenting as melena with long-term survival: A case report and review of literature

Ozaka

Inoue

Okajima

et al. 2021

WJG

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“…Overall, a considerable improvement in survival after SCT has been seen; however, younger patients with few comorbidities who can tolerate the high-dose chemotherapy will probably benefit more than any other population. This therapeutic option needs to be considered cautiously, as many of them present with poor performance status and malnutrition, which may worsen tolerance to chemotherapy or impair them to finalise treatment [ 1 , 6 , 40 ].…”

Section: Discussion/literature Reviewmentioning

confidence: 99%

Use of PEG-asparaginase in monomorphic epitheliotropic intestinal T-cell lymphoma, a disease with diagnostic and therapeutic challenges

Sánchez

Qian

Barbieri

et al. 2017

ecancer

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Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), previously known as enteropathy associated T-cell lymphoma (EATL) type II, is a rare haematological malignancy with a difficult and delayed diagnosis. Symptoms can include abdominal pain, weight loss, and chronic diarrhoea. However, most patients are only diagnosed after complications, such as perforation or obstruction, have developed. There is no standard treatment for MEITL; most accepted regimens consist of surgical resection and anthracycline-based chemotherapy. Prognosis is poor with an approximate survival of less than a year. Even though other therapies, such as autologous stem cell transplant, has shown promising results, not all patients can tolerate this course of treatment especially if they are elderly, have several comorbidities or are malnourished. Innovative therapies that improve survival and can be used as an alternative for more intensive treatment are needed. We report the use of PEG-asparaginase along with conventional anthracycline therapy in a 70-year-old woman diagnosed with MEITL, who went into remission and survived for more than one year before succumbing to relapsed disease.

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Enteropathy-Associated T-Cell Lymphomas

Teja

Mehta‐Shah²

2019

Novel Therapeutics for Rare Lymphomas

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Successful Treatment of Refractory Enteropathy-Associated T-Cell Lymphoma Using High-Dose Chemotherapy and Autologous Stem Cell Transplantation

Cited by 8 publications

References 19 publications

Monomorphic epitheliotropic intestinal T-cell lymphoma presenting as melena with long-term survival: A case report and review of literature

Monomorphic epitheliotropic intestinal T-cell lymphoma presenting as melena with long-term survival: A case report and review of literature

Use of PEG-asparaginase in monomorphic epitheliotropic intestinal T-cell lymphoma, a disease with diagnostic and therapeutic challenges

Enteropathy-Associated T-Cell Lymphomas

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