Successful Treatment Outcomes for Partial Thickness Burns by Innovative Bovine Peritoneum Dressing

Abstract

Summary: In the world practice of treating burns, acellular matrices have been used for quite a long time. However, the budget for treating one burn patient in Kazakhstan does not exceed $1000. This amount does not cover the costs for procurement of foreign-made xenograft dressings. Because the cattle breeding sector is very well-developed in the country, a domestic xenograft is produced by decellularization and sterilization of the cattle peritoneum, which costs only $10. This case report outlines how we used this matrix in a patient with partial thickness burns. A 45-year-old woman was admitted to the burn department with second stage burns on her back and right shoulder. The burn area comprised 10%, according to the Lund Browder chart. Once formal consent was obtained from the patient, an occlusive dressing was applied from the decellularized cattle peritoneum. Good adhesion of the dressing to the wound bed was noted. The patient was discharged from the hospital on the tenth day. It took 23 days to reach complete epithelialization. No adverse effects were noted. We believe that further studies conducted by our research team will allow this innovative, low-cost, easy-to-apply biologic dressing to be widely used in the therapeutic treatment of burns.

Animal tissue-derived biomaterials for promoting wound healing

“…53,54 As a result, dECM has been generated from a variety of tissue sources, including dermis, skin flaps, peritoneum, and intestinal tissues, for use as skin substitutes. [55][56][57] In particular, numerous methods for decellularization have been researched, such as acid treatment, alkali treatment, enzyme treatment, freeze/thaw cycles method and so on. [58][59][60][61] Practically, for a more global optimal decellularization protocol in actual experiments, their combinations are more frequently used.…”

Therapeutic Treatment of 2A Grade Burns with Decellularized Bovine Peritoneum as a Xenograft: Multicenter Randomized Clinical Trial

“…The patients in both groups underwent mechanical debridement of the wound from external contaminants, and superficial necrotic tissue and blisters were removed. After that, 2% chlorhexidine gluconate was used to treat the wounds [15].…”