Successful treatment with continuous subcutaneous insulin infusion for allergy to human insulin and its analogs

Zhang, Lin; Zhang, Mei; Liu, Yuan Yuan; Hu, Maoqing; Zhou, Xue-Lei; Luo, Yong

doi:10.1016/j.diabres.2011.06.015

Cited by 5 publications

(7 citation statements)

References 12 publications

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“…40,42 The presence of pruritus was consistent in all three cases with wheal-and-flare reactions noted in two. 40,42 The reported onset of these reactions ranged from 5 to 10 min and lasted anywhere from several hours to a full day. Confirmatory testing for insulin hypersensitivity included SPT, IDT and laboratory evaluation for elevated antibody levels.…”

Section: Literature Reviewsupporting

confidence: 63%

“…Bolus insulin analogs Aspart. Case reports describing hypersensitivity reactions to aspart included localized reactions, [40][41][42] with two cases progressing to systemic reactions. 40,42 The presence of pruritus was consistent in all three cases with wheal-and-flare reactions noted in two.…”

Section: Literature Reviewmentioning

confidence: 99%

“…Case reports describing hypersensitivity reactions to aspart included localized reactions, [40][41][42] with two cases progressing to systemic reactions. 40,42 The presence of pruritus was consistent in all three cases with wheal-and-flare reactions noted in two. 40,42 The reported onset of these reactions ranged from 5 to 10 min and lasted anywhere from several hours to a full day.…”

Section: Literature Reviewmentioning

confidence: 99%

“…49,51 The selection of the ideal HIA for desensitization may be assisted by using the least reactive insulin for the patient (identified via confirmatory testing) when implementing the protocol 14 . CSII has also been successfully used in patients who experienced difficulty while attempting desensitization protocols via subcutaneous injections 40,42 . Other potential management strategies include conversion to an alternative insulin therapy 37,41 ; concurrent use of antihistamines, steroids, immunosuppressant/immunomodulator therapies [52][53][54] ; and even pancreas transplantation.…”

Section: Data Synthesismentioning

confidence: 99%

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Hypersensitivity reactions to human insulin analogs in insulin-naïve patients: a systematic review

Bzowyckyj

Stahnke

2017

Therapeutic Advances in Endocrinology

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Objective: The objective of this study was to raise awareness of hypersensitivity reactions to human insulin analogs (HIAs) in insulin-naïve patients and encourage consistent and detailed reporting of HIA reactions. Data sources: A search of PubMed, MEDLINE and International Pharmaceutical Abstracts using the terms 'insulin' and 'hypersensitivity' was completed with English language, humans, and publication date after 1 January 1990 as limits. Study selection and data extraction: The initial search identified 598 articles. These titles and abstracts were reviewed for relevance (e.g. mention of HIA) resulting in the exclusion of 477 articles. The full texts of the remaining titles were evaluated in addition to each article's references to identify additional reports meeting criteria (n = 14). Upon extensive review, 118 articles were excluded for not meeting prespecified inclusion criteria, resulting in 17 articles. Data synthesis: Evidence supporting hypersensitivity reactions to HIAs was variable, potentially due to a variety of causes (e.g. difficulty identifying a true case of hypersensitivity reaction to HIAs). Inconsistencies were noted for the identification, confirmatory testing, management, and reporting of these reactions. Management strategies included use of insulin desensitization protocols, antihistamines, steroids, immunosuppressant/immunomodulator therapies, conversion to noninsulin therapies, and pancreas transplantation. Conclusions: Complete and consistent identification, evaluation, management, and reporting of these reactions is essential. Specific aspects of the patient's history should be reported, including previous insulin exposure, the specific HIAs used, duration of use prior to the reaction, a clear timeline of the reaction, and discussion of precipitating events or confounding factors.

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Section: Literature Reviewsupporting

confidence: 63%

Section: Literature Reviewmentioning

confidence: 99%

Section: Literature Reviewmentioning

confidence: 99%

Section: Data Synthesismentioning

confidence: 99%

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Hypersensitivity reactions to human insulin analogs in insulin-naïve patients: a systematic review

Bzowyckyj

Stahnke

2017

Therapeutic Advances in Endocrinology

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“…A recent case report documented the successful treatment of a woman with allergy to human insulin and its analogs with continuous subcutaneous infusion of human insulin [166].…”

Section: Insulin Therapymentioning

confidence: 99%

Diabetic Ketoacidosis

Cesur¹,

Sayi²

2013

Type 1 Diabetes

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Desensitization of allergy to human insulin and its analogs by administering insulin aspart and insulin glargine

Cheng

Wang

et al. 2013

Annales d'Endocrinologie

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Successful treatment with continuous subcutaneous insulin infusion for allergy to human insulin and its analogs

Cited by 5 publications

References 12 publications

Hypersensitivity reactions to human insulin analogs in insulin-naïve patients: a systematic review

Hypersensitivity reactions to human insulin analogs in insulin-naïve patients: a systematic review

Diabetic Ketoacidosis

Desensitization of allergy to human insulin and its analogs by administering insulin aspart and insulin glargine

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