Successful treatment with UVA rush hardening in a case of solar urticaria

Mori, Naoya; Makino, Teruhiko; Matsui, Kenichi; Takegami, Yoshiaki; Murayama, Shotaro; Shimizu, Tadamichi

doi:10.1684/ejd.2013.2238

Cited by 3 publications

(4 citation statements)

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“…While previous therapeutic approaches for light hardening with PUVA [31,36] or UVA therapy [32][33][34][35] were often successful, inducing tolerance was very time consuming.…”

Section: ) Patientsmentioning

confidence: 99%

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Solar urticaria: Clinic, diagnostic, course and therapy management in 27 patients

Gaebelein-Wissing

Ellenbogen

Lehmann

2020

J Deutsche Derma Gesell

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Background and objectives: Solar urticaria is a rare photodermatosis, the diagnosis and therapy of which have not yet been standardized. The aim of this research was to use innovative radiation sources for diagnostics with defined and reproducible emission spectra and doses. A uniform therapy step scheme was to be created. Patients and methods: In a longitudinal study, 27 patients with solar urticaria were examined over 13 years. With a characteristic anamnesis, the diagnosis was confirmed with phototesting (photoprovocation) from various radiation sources (UVB, UVB-311nm, UVA, UVA-1, green light, red light) and a therapy step scheme was designed consisting of light protection, antihistamines, rush hardening with UVA-1, and administration of omalizumab. Results: Action spectrum: UVB 44 %, UVA 70 %, UVA-1 89 %, green light 37 % and red light 22 %. Rush hardening with subsequent maintenance therapy was performed on 20 patients, 17 of whom were hereby adequately protected. In three further patients, omalizumab was additionally administered. Conclusions: Phototesting with UVB, UVB311nm, UVA, UVA-1, and visible light with innovative radiation sources is uniformly possible in every major skin clinic. With the help of the therapy step scheme the patients can be adjusted well. Rush hardening with UVA-1 is a safe method to help the patients during the sunny season. Omalizumab as the last therapy option is effective, but currently only possible in off-label use.

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“…While previous therapeutic approaches for light hardening with PUVA [31,36] or UVA therapy [32][33][34][35] were often successful, inducing tolerance was very time consuming.…”

Section: ) Patientsmentioning

confidence: 99%

“…The following types of phototherapy have been presented most often as effective: systemic PUVA therapy, if necessary in combination with systemic glucocorticoids [31], irradiation with UVA [32][33][34][35][36], irradiation with broadband or narrowband UVB [36][37][38].…”

Section: Introductionmentioning

confidence: 99%

Solar urticaria: Clinic, diagnostic, course and therapy management in 27 patients

Gaebelein-Wissing

Ellenbogen

Lehmann

2020

J Deutsche Derma Gesell

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“…Bisherige Therapieansätze zum Light‐Hardening mit PUVA [31,36] oder UVA‐Therapie [32--35], waren häufig erfolgreich, es war allerdings ein großer Zeitaufwand nötig, bis eine Toleranz induziert werden konnte.…”

Section: Diskussionunclassified

“…Die folgenden Formen der Phototherapie wurden am häufigsten als effektiv dargestellt: systemische PUVA‐Therapie, gegebenenfalls in Kombination mit systemischen Glukokortikoiden [31], Bestrahlung mit UVA [32--36], Bestrahlung mit Breitband‐ oder Schmalspektrum‐UVB [36--38].…”

Section: Introductionunclassified