Successive spectrophotometric resolution as a novel technique for the analysis of ternary mixtures of pharmaceuticals

A comparative study of novel spectrophotometric resolution techniques applied for pharmaceutical mixtures with partially or severely overlapped spectra

“…In this work, two recently introduced resolution techniques were applied namely successive [21][22][23] and progressive resolution techniques [24][25][26]. The resolution of spectra of the cited drugs can be achieved via those techniques based on the use of smart original mathematical techniques where successive techniques consist of several consecutive steps utilizing ratio of zero order absorption and/or derivative spectra while, progressive resolution consists of single manipulation step.…”

“…Successive resolution technique [21][22][23] based on the use of smart original mathematical techniques utilizing the constants which were previously applied for the analysis of binary mixture where the spectrum of one component was extended than the other using either ratio subtraction method [21,[25][26][27] or its newly developed extension namely spectrum subtraction [27], while the resolution technique based on derivative technique was introduced for the analysis of severely overlapped spectra of multi component dosage forms whether ternary or more, or as mixtures with their degradation products [22] which improved resolution bands, eliminated the influence of interfering components and minimized the degree of overlapping so partially overlapped spectra were obtained thus improving the performance of the proposed methods to achieve the complete resolution [21].…”

“…Successive Spectrophotometric resolution technique [21][22][23] based on the use of smart original mathematical techniques utilizing the constants of which were previously applied for the analysis of binary mixture where the spectrum of one component was extended than the other [22]. Recently, the constants of the ratio spectra of either zero order absorption spectra as in ratio subtraction or derivative spectra as in derivative subtraction were applied successfully as resolution techniques for solving spectra [21].…”

Mean centering of double divisor ratio spectra, a novel spectrophotometric method for analysis of ternary mixtures

“…Ternary mixtures suffer a higher degree of difficulty in spectrophotometric resolution than binary mixtures, due to the severe overlap usually noticed in their spectra. Many methods have been developed for resolution of the overlapped spectra of ternary mixtures using different spectrophotometric and chemometric techniques [1][2][3][4][5][6][7][8].…”

A novel pure component contribution algorithm (PCCA) for extracting components’ contribution from severely overlapped signals; an application to UV-spectrophotometric data

“…Afkhami and Bahram [16] developed successive derivative ratio spectra in which two successive derivative steps have been performed on ratio spectra. Amplitude factor [17] and derivative subtraction [18] were also developed and based on derivatization as a basic manipulation step. However, the advantages of derivative spectra are at least partially offset by degradation in signal-to-noise ratio that accompanies derivative calculations.…”