Succinic acid from renewable resources as a C<sub>4</sub>building-block chemical—a review of the catalytic possibilities in aqueous media

Delhomme, Clara; Weuster‐Botz, Dirk; Kühn, Fritz E.

doi:10.1039/b810684c

Cited by 320 publications

(235 citation statements)

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“…Based on our results, we speculate that enhanced succinic acid production is caused by an increased NADH/NAD + ratio resulting from the introduction of pntAB, and by increased ATP formation that occurs as a result of enhanced acetic acid production. Succinic acid is an important compound as a building block of useful chemicals (Cheng et al, 2012;Delhomme et al, 2009). Many studies on metabolic engineering of microorganisms for succinic acid production have been reported ( Okino et al, 2008;Thakker et al, 2012;Wang et al, 2011a, b;Wendisch et al, 2006;Wieschalka et al, 2013;Yuzbashev et al, 2010;Zhang et al, 2009Zhang et al, , 2010.…”

Section: Discussionmentioning

confidence: 99%

Enhanced acetic acid and succinic acid production under microaerobic conditions by Corynebacterium glutamicum harboring Escherichia coli transhydrogenase gene pntAB

Yamauchi¹,

Hirasawa²,

Nishii³

et al. 2014

J. Gen. Appl. Microbiol.

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Some microorganisms, such as Escherichia coli, harbor transhydrogenases that catalyze the interconversion between NADPH and NADH. However, such transhydrogenase genes have not been found in the genome of a glutamic acid-producing bacterium Corynebacterium glutamicum. In this study, the E. coli transhydrogenase genes udhA and pntAB were introduced into the C. glutamicum wild-type strain ATCC 13032, and the metabolic characteristics of the recombinant strains under aerobic and microaerobic conditions were examined. No major metabolic changes were observed following the introduction of the E. coli transhydrogenase genes under aerobic conditions. Under microaerobic conditions, significant metabolic change was not observed following the introduction of the udhA gene. However, the specific production rates of lactic acid, acetic acid, and succinic acid, and the overall production levels of acetic acid and succinic acid were increased by introducing the E. coli pntAB gene. Moreover, the NADH/NAD + ratio was increased by introduction of pntAB. Our results suggest that the E. coli PntAB transhydrogenase enhances the conversion of NADPH to NADH in C. glutamicum under microaerobic conditions, and the increased NADH/NAD + ratio results in increased succinic acid production. In addition, acetic acid production might be enhanced to supply ATP to the anaplerotic reaction catalyzed by pyruvate carboxylase.Key words: acetic acid; Corynebacterium glutamicum; pntAB; redox balance; succinic acid; transhydrogenases IntroductionMany oxidation and reduction reactions are involved in cellular metabolism, most of which require pyrimidine nucleotide cofactors, such as nicotinamide adenine dinucleotide (NAD + ) and nicotinamide adenine dinucleotide phosphate (NADP + ) and their reduced forms NADH and NADPH, to supply oxidizing and reducing equivalents. Generally, NADH is produced via catabolism, and is oxidized in the respiratory chain under aerobic conditions or by fermentation under anaerobic conditions. Anabolic reactions to produce cell biomass components, such as fatty acid and amino acid biosynthesis, require NADPH as a reducing equivalent. Therefore, maintaining the intracellular balance of NAD(P) + and NAD(P)H is very important for most intracellular metabolic reactions to occur.Some organisms contain the enzymes catalyzing the following interconversion of NADH and NADPH, called transhydrogenase:NADPH + NAD + NADP + + NADH. To date, two types of transhydrogenases have been identified; the cytoplasmic-soluble and membrane-bound types. Membrane-bound transhydrogenases have been found in the inner mitochondrial membrane of eukaryotic cells and in the cytoplasmic membrane of many bacteria, and simultaneously catalyze proton translocation across a membrane. Full PaperEnhanced acetic acid and succinic acid production under microaerobic conditions by Corynebacterium glutamicum harboring Escherichia coli transhydrogenase gene pntAB (Received April 3, 2014; Accepted April 8, 2014) Yuto Yamauchi, None of the authors of this manuscript ha...

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Section: Discussionmentioning

confidence: 99%

Enhanced acetic acid and succinic acid production under microaerobic conditions by Corynebacterium glutamicum harboring Escherichia coli transhydrogenase gene pntAB

Yamauchi¹,

Hirasawa²,

Nishii³

et al. 2014

J. Gen. Appl. Microbiol.

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“…Vacuum distillation and crystallisation of fermentation products afforded highly-crystalline succinic acid, at up to 35% overall yield. 144 The DuPont process 145 for converting succinic acid to 1,4-BDO uses a 1% Pd-4% Re/TiO 2 catalyst, under 69 bar H 2 at 200°C, providing 1,4-BDO at 89% overall yield (eqn (41)). …”

Section: ð40þmentioning

confidence: 99%

Catalytic routes towards acrylic acid, adipic acid and ε-caprolactam starting from biorenewables

2015

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“…Currently, the main catalysts widely applied in the MAH processes are noble metal catalysts (Pd, Ru and Au) [4] and transition metal copper chromite (Cu-Cr) catalysts [5], though they are either costly, less selective or toxic. For developing environmentally-friendly and low-cost alternative MAH catalysts, extensive efforts have been made on: (1) exploring various transition metal Ni [1,2,6], Co [3], Cu [7][8][9] and bimetallic catalysts [10] with controlled particle sizes and surface dispersion; (2) modifying the traditional porous Al 2 O 3 [11], SiO 2 [3], zeolite [2] and SiO 2 -Al 2 O 3 composite oxide supports [8] using functional promoters (e.g., CeO 2 [12], TiO 2 [13] and ZrO 2 [14], etc.)…”

Section: Introductionmentioning

confidence: 99%

The Catalytic Hydrogenation of Maleic Anhydride on CeO2−δ-Supported Transition Metal Catalysts

et al. 2017

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Abstract:The proper selection of transition metals and support is pivotal to the design of active and selective catalysts for maleic anhydride hydrogenation (MAH). Herein, the M/CeO 2−δ (M = Co, Ni, Cu, respectively) catalysts with pre-optimised metal loading of 10 wt % were prepared via a wet impregnation method and well characterized to corroborate their MAH performance with the properties of metal, support and the M/CeO 2−δ catalysts. The results revealed that the metal dispersion on the catalyst declines in the order of Ni/CeO 2−δ > Co/CeO 2−δ > Cu/CeO 2−δ , similar to the apparent activity for maleic anhydride (MA) transformation to succinic anhydride (SA). The hydrogenolysis of SA to γ-butyrolactone (GBL) occurs on Ni/CeO 2−δ and Co/CeO 2−δ only when the MA → SA transformation completing. The Ni/CeO 2−δ displays superior activity and selectivity to Co/CeO 2−δ in both MA → SA and SA → GBL reactions, while the Cu/CeO 2−δ and CeO 2−δ are both inert for SA → GBL hydrogenolysis. The MA hydrogenation to SA follows the first order kinetic law on the Ni/CeO 2−δ and Co/CeO 2−δ catalysts yet a more complex kinetic characteristics observed on the Cu/CeO 2−δ . The distinct catalytic hydrogenation behaviours of the M/CeO 2−δ catalysts are assigned to the synergism of dispersion and electronic configuration of the transition metals and oxygen vacancies.

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Succinic acid from renewable resources as a C₄building-block chemical—a review of the catalytic possibilities in aqueous media

Cited by 320 publications

References 32 publications

Enhanced acetic acid and succinic acid production under microaerobic conditions by Corynebacterium glutamicum harboring Escherichia coli transhydrogenase gene pntAB

Enhanced acetic acid and succinic acid production under microaerobic conditions by Corynebacterium glutamicum harboring Escherichia coli transhydrogenase gene pntAB

Catalytic routes towards acrylic acid, adipic acid and ε-caprolactam starting from biorenewables

The Catalytic Hydrogenation of Maleic Anhydride on CeO2−δ-Supported Transition Metal Catalysts

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Succinic acid from renewable resources as a C4building-block chemical—a review of the catalytic possibilities in aqueous media

Cited by 320 publications

References 32 publications

Enhanced acetic acid and succinic acid production under microaerobic conditions by Corynebacterium glutamicum harboring Escherichia coli transhydrogenase gene pntAB

Enhanced acetic acid and succinic acid production under microaerobic conditions by Corynebacterium glutamicum harboring Escherichia coli transhydrogenase gene pntAB

Catalytic routes towards acrylic acid, adipic acid and ε-caprolactam starting from biorenewables

The Catalytic Hydrogenation of Maleic Anhydride on CeO2−δ-Supported Transition Metal Catalysts

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Succinic acid from renewable resources as a C₄building-block chemical—a review of the catalytic possibilities in aqueous media