Succinic Ester‐Based Shape Memory Gelatin Sponge for Noncompressible Hemorrhage without Hindering Tissue Regeneration (Adv. Healthcare Mater. 5/2023)

Zhu, Yong‐Guan; Zhang, Lining; Duan, Wanglin; Martín-Saldaña, Sergio; Li, Chaowei; Yu, Huimei; Li, Feng; Zhang, Xianpeng; Du, Baoji; Li, Guanying; Zheng, Xifu; Bu, Yazhong

doi:10.1002/adhm.202370021

Cited by 4 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Stainless steel drill was used to form cylindrical bone holes on the inner surface of the tibia (Φ2 × 3 mm). [ 59 ] Then, each defect was injected with sterile saline solution to remove bone debris, and the materials of each group were implanted or left blank. SD rats of each group were killed at day 1, 2, 4, and 7 after operation, and 2 mL of whole blood samples were taken for blood biochemical determination.…”

Section: Methodsmentioning

confidence: 99%

Sea Cucumber‐Inspired Aerogel for Ultrafast Hemostasis of Open Fracture

Han

Feng

et al. 2023

Adv Healthcare Materials

View full text Add to dashboard Cite

The symptomatic management of hemorrhagic shock complicated by open fractures is a great challenge, because it is also complicated by complex wound bleeding, bacterial infection, and bone defects. Inspired by the water absorption and cross‐sectional microstructure of sea cucumbers, in this study, a new sea cucumber‐like aerogel (GCG) is proposed. Its aligned porous structure and composition can stop bleeding rapidly and effectively with a blood clotting index of 3.73 ± 1.8%. More importantly, the data of in vivo hemostasis test in an amputating rat tail hemostatic model (15.69 ± 2.45 s, 26.95 ± 8.43 mg) and liver puncture bleeding model (23.77 ± 2.68 s, 36.22 ± 16.92 mg) also indicate the excellent hemostatic performance of GCG. In addition, GCG also shows a significant inhibitory effect on S. aureus and E. coli, which can prevent the occurrence of postoperative osteomyelitis. Not only that, after filling in the bone defect, it is shown that this GCG aerogel completely degrades eight weeks after surgery and induces new bone ingrowth, achieving functional regeneration after hemostasis of an open fracture defect. Generally, because of its combination of hemostatic, antibacterial, and osteogenic activities, this new aerogel is a promising option for open fractures treatment.

show abstract

Section: Methodsmentioning

confidence: 99%

Sea Cucumber‐Inspired Aerogel for Ultrafast Hemostasis of Open Fracture

Han

Feng

et al. 2023

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…Notably, PBEAGA-CPT demonstrated the capability to completely eliminate tumors measuring 500 mm 3 in nude mouse models (Figure 10e,f ). In a separate endeavor, Tang et al [225] designed a prodrug exhibiting a [29] Orthotopic pancreatic cancer model [226] Liver cancer model [228] Aminopeptidase N (APN) APN hydrolysis to generate cationic groups for AMT Liver cancer model [218] MMP-2 hydrolysis to generate cationic groups for AMT Breast cancer model [229] pH Matrix Metalloproteinase-2 (MMP-2) Charge reversal from negative to positive under acidic environment Prostate cancer model [35] Orthotopic pancreatic cancer model [38] Acidic tumor microenvironments Breast cancer model [230,231] Size decrease and charge reversal under acidic environment…”

Section: Transcytosis-based Stimuli-responsive Nanocarriers For Cance...mentioning

confidence: 99%

“…Indeed, pH-triggered transcytosis systems represent the most extensively investigated models in the field of stimuli-responsive transcytosis nanosystems to date. [35,38,209,[229][230][231][232] In the research by Zhang group, [35] they harnessed both the charge reversal responsive to acidic tumor microenvironment and transcytosis strategies to augment tumor penetration. They formulated small morph NPs (PDMA) by modifying polyamidoamine (PAMAM) dendrimers with dimethylmaleic anhydride (DMA).…”

Section: Transcytosis-based Stimuli-responsive Nanocarriers For Cance...mentioning

confidence: 99%

Stimuli‐Responsive Nanocarriers for Transcytosis‐Based Cancer Drug Delivery

Wang,

Sun,

Shen

et al. 2024

Advanced NanoBiomed Research

View full text Add to dashboard Cite

Significant challenges persist in enhancing the delivery efficiency of tumor nanomedicines, predominantly due to the difficulty of successfully surpassing pathophysiological barriers. Enhancing tumor penetration of nanomedicines in such conditions represents a pivotal goal in advancing anticancer nanotherapeutics. Transcytosis emerges as a promising solution in this context, addressing the limitations of passive drug delivery. By harnessing diverse stimuli to induce transcytosis, nanocarriers can achieve precise drug delivery and deep tumor penetration, resulting in high therapeutic efficacy and reduced systemic exposure to the therapeutic compound. This review briefly examines various stimuli‐responsive nanosystems and offers an overview and outlook on the development of stimuli‐responsive nanocarriers for transcytosis‐based cancer drug delivery, aiming to provide informative insights for the design of nanomedicines capable of deep tissue penetration and enhanced therapeutic efficacy.

show abstract

“…When the albumin is exogenous, it can form stable complexes with the molecules in vitro, making it suitable for injection purposes, such as the Nab paclitaxel (Abraxane) for chemotherapy, 74 cyanine@albumin for NIR imaging and imaging-guided surgery. [38][39][40]75 This allows for controlled delivery of the molecules to specific sites in the body. On the other hand, when the albumin is endogenous, it can in situ encapsulate the molecules, resulting in in vivo complexing or tagging.…”

Section: Shoujun Zhumentioning

confidence: 99%

“…In addition, we found that the metabolic half-life of ICG is significantly shorter compared to Cl-containing dyes such as IR-780, IR-808, and IR-783. 75 Due to the presence of numerous exposed cysteine residues in albumin, Tian et al conducted an experiment to identify the precise binding site of Cl-containing cyanine dyes on albumin (Fig. 4).…”

Section: Study On the Binding Mechanism Of Cl-containing Cyanine Dyes...mentioning

confidence: 99%