Sucralfate as an Adjunct to Analgesia to Improve Oral Intake in Children With Infectious Oral Ulcers: A Randomized, Double-Blind, Placebo-Controlled Trial

Singh, Nidhi; Gabriele, Giovanni; Wilkinson, Matthew

doi:10.1016/j.annemergmed.2021.01.019

Cited by 2 publications

(2 citation statements)

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“…SCF join tightly to the inflamed mucosa, forming a stable and insoluble layer that protect damaged epithelium 20,21 . SCF improves the healing of inflamed mucosa, has an antioxidant and anti-inflammatory properties, and stimulates the production of EGF [18][19][20][21][22][23][24] . Authors who evaluated the effects of SCF using models of chemically-induced colitis have shown that the application of clysters with SCF increases mucosal repair, probably through increasing mucus production, which favors epithelial healing 31,32 .…”

Section: Discussionmentioning

confidence: 99%

“…Due to all these features, SCF has been used for several years to heal different types of cutaneous lesions, such as surgical wounds and those caused by skin ulcers, mucositis, and mucosal ulceration of the gastrointestinal tract [18][19][20][21][22] . Enemas with SCF have also been considered a promising tool for the treatment of different types of colitis 14,[23][24][25] .…”

Section: Introductionmentioning

confidence: 99%

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Sucralfate enemas reduce the oxidative tissue damage and preserves the contents of E-cadherin and ?-catenin in colonic mucosa without fecal stream

et al. 2021

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Purpose: To evaluate the effects of sucralfate enemas in tissue contents of E-cadherin and β-catenin in an experimental diversion colitis. Methods: Thirty-six male Wistar rats were submitted to a proximal colostomy and a distal mucous fistula. They were allocated into three groups: first group received daily saline enemas (2 mL/day) and the two other groups daily enemas with sucralfate at dosage of 1 or 2 g/kg/day, respectively. Six animals of each group were euthanized after two weeks and six animals after four weeks. The inflammation of the excluded mucosa was evaluated by histological analysis. The oxidative damage was quantified by measurement of malondialdehyde tissue levels. The expression of E-cadherin and β-catenin was identified by immunohistochemistry, and its contents were quantified by computer-assisted image analysis. Results: Sucralfate enemas reduced inflammation in animals subjected to treatment with 2 g/kg/day by four weeks, and the levels of oxidative damage in mucosa without fecal stream irrespective of concentration and time of intervention. E-cadherin and β-catenin content increased in segments without fecal stream in those animals subjected to treatment with sucralfate. Conclusion: Sucralfate reduces the inflammation and oxidative stress and increases the tissue content of E-cadherin and β-catenin in colonic mucosa devoid to the fecal stream.

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