Sucrose Diet Elevates Cardiovascular Risk Factors in Male Albino Rats

Salau, Bamidele Adewale; Olooto, Wasiu Eniola; Adebayo, Olusegun L.; Ajani, Emmanuel Oladipo; Odufuwa, Kuburat Temitope; Olowookere, Julius O.

doi:10.3923/ijbc.2012.61.68

Cited by 7 publications

(3 citation statements)

References 7 publications

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“…Similar results were observed by (37) on alloxan-induced diabetic rats after oral administration of Bauhinia thoningii . Similar results were reported by (39) . Rats with high AI and CRI indexes are at a high risk of diseases like diabetes as evidenced also by their higher Hb1Ac levels.…”

Section: Resultssupporting

confidence: 93%

Hypolipidaemic effects of papaya (Carica papayaL.) juice on rats fed on a high fat and fructose diet

et al. 2023

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Papaya (Carica papaya L.) is a highly nutritious and less-caloric fruit, commonly consumed for its minerals and vitamins and hence may help in controlling obesity and abdominal discomforts. The present study investigated the hypolipidaemic effects of papaya juice extract on male Albino Wistar rats (7 weeks old; 185 ± 17 g) fed on a high fat and fructose diet (HFFD) for 6 weeks. The rats were divided into groups I–IV of five rats each and fed on either a HFFD (i.e. the Control), HFFD + 200 mg papaya, HFFD + 350 mg papaya or a HFFD + 500 mg papaya. On day 34, after an overnight fast, blood samples were obtained by cardiac puncture under 99⋅8 % Chloroform anaesthesia for the determination of serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c) and high-density cholesterol (HDL-c). The atherogenic (AI) and coronary risk (CRI) indices were also calculated. Statistical analysis was performed using ANOVA where means were separated using Tukey's HSD test. Resulted showed that all rats given papaya juice had an increasing, non-significant HDL-c and reduced LDL-c levels while rats fed on HFFD had the highest TC (53⋅2 mg/dl) and TG (37⋅6 mg/dl) levels. Papaya juice statistically reduced the AI and CRI of the rats. In conclusion, consumption of HFFD + 500 mg was the most effective in the reduction of rats’ blood lipids and fats, due to its anti-obesity and hypolipidaemic properties, thus can be used in the management of dyspilidaemic disorders.

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Section: Resultssupporting

confidence: 93%

Hypolipidaemic effects of papaya (Carica papayaL.) juice on rats fed on a high fat and fructose diet

et al. 2023

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“…Therefore, the pro-oxidants attack cholesterol and oxidise them. The oxidised cholesterol is not recognised by normal cholesterol receptor, and consequently there is demand from the cells for more cholesterol to be synthesised in order to meet and perform their biochemical roles [46] , thereby activating HMGCR. Free radical generation leading to the induction of cholesterol biosynthesis in AD has been described [45] .…”

Section: Discussionmentioning

confidence: 99%

Dietary Selenium or Zinc Supplementation Restores Brain Lipid Composition and Membrane Fluidity in Protein-Undernourished Rats

Adebayo

Salau²,

Sandhir³

et al. 2016

Dev Neurosci

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Studies have shown that protein undernutrition (PU) modifies the membrane lipid composition in the intestine and liver, as well as in plasma and other areas. However, there is limited information on the effect of PU on synaptosomal membrane lipid composition and fluidity and the protective role of selenium (Se) and zinc (Zn), which is a major focus of the present study. For 10 weeks, rats were fed diets containing 16% casein, which constituted the adequate protein diet, or 5% casein, representing the PU diet. The animals were supplemented with Se and Zn at a concentration of 0.15 and 227 mg L^-1, respectively, in drinking water for 3 weeks. The results showed a significant increase in total lipids, glycolipids, triglycerides, cholesterol, and the cholesterol/phospholipid (Chol/PL) ratio, and a significant reduction in phospholipids and membrane fluidity. Se and Zn supplementation to PU rats, however, significantly lowered total lipids, glycolipids, triglycerides, cholesterol, and the Chol/PL ratio, while phospholipids and membrane fluidity were significantly restored. It is concluded that a perturbed lipid composition induced by PU affects the membrane structure and fluidity, which in turn influences membrane functions. The study suggests that Se and Zn supplementation might be beneficial in restoring the lipid dyshomeostasis associated with PU.

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“…Sucrose diet has been shown to cause different disorders in humans and animal models (Salau et al,2013;Salau et al, 2012;Sivabalan and Menon, 2008) some of those abnormalities include derangement in fasting blood glucose, oral glucose tolerance test and body weight (Salau et al, et al 2011;Saris, 2003). However, intake of other dietary components may have a moderating effect on some of these parameters.…”

Section: Introductionmentioning

confidence: 99%

Beniseed Diet Moderates Blood Glucose and Body Weght in Rat Fed High Sucrose Diet

M.M¹

2013

IOSR-JDMS

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Sucrose Diet Elevates Cardiovascular Risk Factors in Male Albino Rats

Cited by 7 publications

References 7 publications

Hypolipidaemic effects of papaya (Carica papayaL.) juice on rats fed on a high fat and fructose diet

Hypolipidaemic effects of papaya (Carica papayaL.) juice on rats fed on a high fat and fructose diet

Dietary Selenium or Zinc Supplementation Restores Brain Lipid Composition and Membrane Fluidity in Protein-Undernourished Rats

Beniseed Diet Moderates Blood Glucose and Body Weght in Rat Fed High Sucrose Diet

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