Suction-Assisted Lipectomy for Lipodystrophy Syndromes Attributed to HIV-Protease Inhibitor Use

Wolfort, Francis G.; Cetrulo, Curtis L.; Nevarre, Daniel R.; Rohrich, Rod J.

doi:10.1097/00006534-199911000-00033

Cited by 23 publications

(19 citation statements)

References 6 publications

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“…Cannulas are used for feathering and refinement with attachment to vacuum curettage. Access site incisions are closed with simple interrupted nylon sutures and elastic compression garment applied [18].…”

Section: Discussionmentioning

confidence: 99%

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Antiretroviral Treatment-Associated Labia Majora Lipohypertrophy: A Rare Case and Plastic Surgical Treatment Options

Hisham¹,

Ilenghoven²,

Kamal³

et al. 2017

JCHS

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The emergence of highly active antiretroviral therapy (HAART) has revolutionized the prognosis of HIV-infected patients. However, the extended use of HAART is associated with a disfiguring complication termed lipodystrophy, a disorder of body fat maldistribution causing peripheral fat loss (lipoatrophy) and central fat accumulation (lipohypertrophy). Lipoatrophy commonly affects the face, legs, buttocks and arm, whilst lipohypertrophy frequently favours the abdomen, breast and dorsocervical region. To our knowledge, we present only the second documented case in the literature of a labia majora lipohypertrophy in a HIV-positive patient receiving long-term HAART. The severity of labial abnormality caused significant physical and functional morbidities. Labiaplasty with dermolipectomy of the labia majora and excisional lipectomy of the mons pubis was successfully performed. At a 6-month follow-up, patient had no recurrence with resolution of symptoms and resumption of normal activities of daily living (ADL).

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Section: Discussionmentioning

confidence: 99%

“…UAL setting of 5-6/10 for duration is expected to yield 50-100ml of cavitation per minute. End points of UAL include loss of resistance within the area of lipohypertrophy, reaching the pre-calculated duration of cavitation, and/or appearance of blood tinged lipoaspirate [18].…”

Section: Discussionmentioning

confidence: 99%

Antiretroviral Treatment-Associated Labia Majora Lipohypertrophy: A Rare Case and Plastic Surgical Treatment Options

Hisham¹,

Ilenghoven²,

Kamal³

et al. 2017

JCHS

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“…Existem alguns relatos de caso utilizando hormônio do crescimento (GH) nesta população; contudo, há controvérsias quanto aos efeitos do GH na homeostase glicídica e no desenvolvimento de neoplasias malignas, às quais estes pacientes já são mais susceptíveis (48). Uma alternativa para os casos de lipodistrofia seria o emprego de procedimentos estéticos como a cirurgia plástica, opção paliativa e que não interfere no perfil metabólico da síndrome (49). Uma droga da classe dos IPs recentemente descoberta, chamada atazanavir, caracteriza-se por sua potência antiviral e segurança, não alterando níveis séricos de colesterol total e triglicérides em pacientes virgens de tratamento antiretroviral (49,50).…”

Section: Lipodistrofia Do Hivunclassified

“…Uma alternativa para os casos de lipodistrofia seria o emprego de procedimentos estéticos como a cirurgia plástica, opção paliativa e que não interfere no perfil metabólico da síndrome (49). Uma droga da classe dos IPs recentemente descoberta, chamada atazanavir, caracteriza-se por sua potência antiviral e segurança, não alterando níveis séricos de colesterol total e triglicérides em pacientes virgens de tratamento antiretroviral (49,50). Estudos demonstram, ainda, que o atazanavir reduziu os níveis de colesterol total, LDL colesterol, triglicérides, gordura abdominal e gibosidade dorsal de indivíduos já em tratamento com a HAART (50-53), surgindo como alternativa para os casos de SLHIV.…”

Section: Lipodistrofia Do Hivunclassified

Alterações metabólicas da síndrome lipodistrófica do HIV

Valente

Reis

Machado

et al. 2005

Arq Bras Endocrinol Metab

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The introduction of highly active antiretroviral therapy (HAART) has reduced morbidity and mortality in patients infected with the human immunodeficiency virus (HIV). However, prolonged treatment with combination regimens can be difficult to sustain because of problems with adherence and toxic effects. Treatment with antiretroviral agents--protease inhibitors in particular--has uncovered a syndrome of abnormal fat redistribution, impaired glucose metabolism, insulin resistance and dyslipidemia, collectively termed lipodystrophy syndrome (SLHIV). Nowadays, no clinical guidelines are available for the prevention or treatment of SLHIV, and its cause have yet to be totally elucidated. This review emphasizes the clinical features and the data from previous studies about the SLHIV taking into account that a better understanding of this syndrome for HIV specialists, cardiologists and endocrinologists is fundamental for the disease control.

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“…Some cases of hyperpigmentation have been related to AZT therapy, although the condition is also reported in HIVinfected patients who have never been given AZT [105].…”

Section: Cutaneous Drug Eruptionsmentioning

confidence: 99%

Skin Diseases Associated with HIV Infection

Innocenzi

2001

Current Topics in Pathology

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Suction-Assisted Lipectomy for Lipodystrophy Syndromes Attributed to HIV-Protease Inhibitor Use

Cited by 23 publications

References 6 publications

Antiretroviral Treatment-Associated Labia Majora Lipohypertrophy: A Rare Case and Plastic Surgical Treatment Options

Antiretroviral Treatment-Associated Labia Majora Lipohypertrophy: A Rare Case and Plastic Surgical Treatment Options

Alterações metabólicas da síndrome lipodistrófica do HIV

Skin Diseases Associated with HIV Infection

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