Suction Cups‐Inspired Adhesive Patch with Tailorable Patterns for Versatile Wound Healing

Abstract

Medical patches play an important role in wound healing because of their tissue conformality, drug release capacity, and convenient operation. Great efforts have been devoted to developing new-generation patches with distinctive features promoting wound healing. Here, inspired by the structure of octopus suction cups and the component of natural tissue, a biocompatible wound patch with selective adhesiveness and individualized design using a combined strategy of template-replication and mask-guided lithography is presented. Such patches are based on Ecoflex film with suction-cup-mimicking microstructures to adhere to normal skin and with biocompatible gelatin methacryloyl (GelMA) hydrogel to contact wounded areas. An ultraviolet mask with a tailorable pattern is employed to shape the GelMA hydrogel into customized geometry replicating individual wound areas, and thus both adhesion and antiadhesion properties are integrated into the same patch. In addition, vascular endothelial growth factor is loaded to accelerate the healing process. Based on these advantages, the authors demonstrate that the present patches not only adhere to different skin surfaces, but also promote the treatment of a rat cutaneous wound model. Thus, it is believed that this versatile patch can break through the limitation of traditional patches and be ideal candidates for wound healing and related biomedical applications.

Improving Biocompatibility of Polyester Fabrics through Polyurethane/Gelatin Complex Coating for Potential Vascular Application

“…As shown in Figure 3 A, there was no major difference between the pristine polyester fabrics with gelatin and polyurethane coating fabrics. Compared with the bare polyester, the polyurethane coating sample showed two new characteristic peaks at 2940 cm −1 and 2860 cm −1 , which was attributed to the stretch vibration of C-H groups [ 31 , 37 , 38 ]. In addition, the two absorption peaks showed as well.…”

Adhesion advances: from nanomaterials to biomimetic adhesion and applications

“…Inspired by the octopus sucker structure and natural tissue composition. Huang et al 120 used a combination strategy of template replication and mask-guided lithography to propose a biocompatible wound patch with selective adhesion and personalized design (Fig. 6C).…”

“…Reproduced with permission. 120 Copyright 2021, Wiley. (D) (a) Schematic diagram of MRP film design with micro suction cups on the surface inspired by octopus.…”

A Composite Hydrogel Containing Mesoporous Silica Nanoparticles Loaded With Artemisia argyi Extract for Improving Chronic Wound Healing

“…The biocompatibility of composite hydrogel is a crucial factor for functional tissue regeneration and a standard for safe application in the biomedical field (Huang et al, 2021). The cytocompatibility of MSN and hydrogels was examined using CCK-8 and live/dead cell staining, respectively.…”