Sudden bilateral sensorineural hearing loss as the presenting symptom of meningeal carcinomatosis of gastric cancer: Report of a case

Ohno, Tetsuro; Yokoyama, Yozo; Aihara, Ryuusuke; Mochiki, Erito; Asao, Takayuki; Kuwano, Hiroyuki

doi:10.1007/s00595-009-4099-1

Cited by 18 publications

(12 citation statements)

References 16 publications

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“…Our patients' clinical manifestations were generally consistent with those previously reported [1,2,5,7], as was their median length of survival (33 days) [1,3]. Cytology of the CSF is the gold standard for LMC cancer diagnosis.…”

Section: Discussionsupporting

confidence: 87%

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Frequent development of leptomeningeal carcinomatosis in patients with peritoneal dissemination of gastric cancer

et al. 2011

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We detected 7 cases of leptomeningeal carcinomatosis in 126 patients with peritoneal dissemination of gastric cancer who received combined systemic and intraperitoneal chemotherapy. Leptomeningeal carcinomatosis was diagnosed 79-1540 days after the diagnosis of the primary gastric cancer. Patients presenting with various neurological symptoms were diagnosed by cerebrospinal fluid (CSF) cytology and radiological imaging. Irradiation to the whole brain and spine was performed in 4 patients, and provided palliation and increased survival for 1 patient. Intrathecal chemotherapy and drainage of CSF was performed in 1 patient each, but produced no significant clinical benefit in either of them. Survival after the diagnosis of leptomeningeal carcinomatosis was between 3 and 155 days. As patients with peritoneal dissemination of gastric cancer are living longer because of improved chemotherapy, clinicians must recognize the possibility of leptomeningeal carcinomatosis when patients complain of neurological symptoms.

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Section: Discussionsupporting

confidence: 87%

“…LMC is thought to be relatively rare in gastric cancer, with a frequency of 0.16-0.69% in all gastric cancer patients [4][5][6][7][8]. Peritoneal metastasis is the most frequent and life-threatening mode of metastasis and recurrence in patients with gastric cancer.…”

Section: Introductionmentioning

confidence: 99%

Frequent development of leptomeningeal carcinomatosis in patients with peritoneal dissemination of gastric cancer

et al. 2011

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“…However, although rare, meningeal carcinomatosis can be the initial and early manifestations of the malignancy (as was observed in our patient) [3],[11]–[18]. In these patients, the diagnosis of meningeal carcinomatosis contributed to the identification of the primary malignancy and the primary tumors were found in the stomach [3],[12], the lung [14],[16], the bronchus [15] and the colon [13]. Common neurological presentations are headache [3],[11],[15] and bilateral deafness [12]–[14].…”

Section: Discussionmentioning

confidence: 71%

“…In these patients, the diagnosis of meningeal carcinomatosis contributed to the identification of the primary malignancy and the primary tumors were found in the stomach [3],[12], the lung [14],[16], the bronchus [15] and the colon [13]. Common neurological presentations are headache [3],[11],[15] and bilateral deafness [12]–[14]. Radiation therapy and chemotherapy including intrathecal methotrexate are used in patients with meningeal carcinomatosis [3],[11],[12],[15],[16].…”

Section: Discussionmentioning

confidence: 99%

Co-occurrence of multiple cerebral infarctions due to hypercoagulability associated with malignancy and meningeal carcinomatosis as the initial manifestation of gastric cancer

et al. 2014

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BackgroundMeningeal carcinomatosis and hypercoagulability associated with malignancy are typical late stage complications in cancer patients. The co-occurrence of meningeal carcinomatosis and cerebral infarction related to hypercoagulability associated with malignancy in an individual as the initial manifestation of malignancy has not been previously reported.Case presentationHerein, we report the case of an 80-year-old patient who presented with meningeal carcinomatosis and hypercoagulability related to malignancy as the initial manifestation of occult gastric cancer. The patient displayed consciousness disturbance, mild left facial paralysis, and bilateral positive Babinski’s sign. Using brain magnetic resonance imaging, the patient was diagnosed as having acute multiple cerebral infarctions. Cerebrospinal fluid (CSF) cytology showed adenocarcinoma and upper gastrointestinal endoscopy disclosed scirrhous gastric cancer. The patient presented with headache, fever, and meningeal irritation with a subacute course. Tuberculous or fungal meningitis was initially suspected; however, cytological evidence of adenocarcinoma in the CSF led to the diagnosis of meningeal carcinomatosis.ConclusionThe comorbidity of hypercoagulability associated with malignancy and meningeal carcinomatosis should be considered in a patient presenting with multiple cerebral infarctions, progressive disturbance of consciousness, fever, and meningeal irritation.

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“…However, very often, the primary cancer is already known, and therefore facilitates the diagnosis of the metastases 7. Gadolinium-enhanced MRI is accepted as the ‘gold standard’ in investigation of CPA tumours 8.…”

Section: Discussionmentioning

confidence: 99%

Lung adenocarcinoma metastastic lesion in the internal auditory meatus

et al. 2017

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Metastasis to the cerebellopontine angle (CPA) or internal auditory meatus (IAM) is rare.We report a rare case of a 69-year-old woman with metastatic lung adenocarcinoma, who presented with 2 weeks history of left-sided hearing loss and progressively worsening vertigo. Examination revealed a left-sided facial nerve palsy while pure tone audiometry (PTA) showed a new left-sided deafness. MRI showed a new enhancing soft tissue lesion in the left IAM, highly suspicious of new metastases from her progressive lung cancer, which contributed to her neuro-otological symptoms. Subsequent MRI scans 4 months later also showed new brain metastases. She continued to be managed with supportive palliative care in view of her extensive disease.

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Sudden bilateral sensorineural hearing loss as the presenting symptom of meningeal carcinomatosis of gastric cancer: Report of a case

Cited by 18 publications

References 16 publications

Frequent development of leptomeningeal carcinomatosis in patients with peritoneal dissemination of gastric cancer

Frequent development of leptomeningeal carcinomatosis in patients with peritoneal dissemination of gastric cancer

Co-occurrence of multiple cerebral infarctions due to hypercoagulability associated with malignancy and meningeal carcinomatosis as the initial manifestation of gastric cancer

Lung adenocarcinoma metastastic lesion in the internal auditory meatus

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