Sudden Death Associated With Possible Flare-Ups of Multiple Sclerosis After COVID-19 Vaccination and Infection: A Case Report and Literature Review

Jeon, Yo Han; Choi, Sangjoon; Park, Ji Hyun; Lee, Jong Kyu; Yeo, Nam Seok; Lee, SangHan; Suh, Yeon Lim

doi:10.3346/jkms.2023.38.e78

Cited by 5 publications

(12 citation statements)

References 29 publications

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“…Ancha Baranova et al concluded from MR analysis that hospitalized COVID-19 increases the risk of multiple sclerosis by 15% ( 35 ). Moreover, several cases of MS have been published that may be associated with COVID-19 vaccination ( 36 ). A case report described a 40-year-old woman who developed cervical myelitis after COVID-19 vaccination, which is considered to be the initial clinical manifestation of MS ( 37 ).…”

Section: Discussionmentioning

confidence: 99%

COVID-19 vaccination and the risk of autoimmune diseases: a Mendelian randomization study

Shan,

Hu,

Chen

et al. 2024

Front. Public Health

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BackgroundIn recent times, reports have emerged suggesting that a variety of autoimmune disorders may arise after the coronavirus disease 2019 (COVID-19) vaccination. However, causality and underlying mechanisms remain unclear.MethodsWe collected summary statistics of COVID-19 vaccination and 31 autoimmune diseases from genome-wide association studies (GWAS) as exposure and outcome, respectively. Random-effects inverse variance weighting (IVW), MR Egger, weighted median, simple mode, and weighted mode were used as analytical methods through Mendelian randomization (MR), and heterogeneity and sensitivity analysis were performed.ResultsWe selected 72 instrumental variables for exposure (p < 5 × 10−6; r2 < 0.001, genetic distance = 10,000 kb), and MR analyses showed that COVID-19 vaccination was causally associated with an increased risk of multiple sclerosis (MS) (IVW, OR: 1.53, 95% CI: 1.065–2.197, p = 0.026) and ulcerative colitis (UC) (IVW, OR: 1.00, 95% CI: 1.000–1.003, p = 0.039). If exposure was refined (p < 5 × 10−8; r2 < 0.001, genetic distance = 10,000 kb), the associations became negative. No causality was found for the remaining outcomes. These results were robust to sensitivity and heterogeneity analyses.ConclusionOur study provided potential evidence for the impact of COVID-19 vaccination on the risk of MS and UC occurrence, but it lacks sufficient robustness, which could provide a new idea for public health policy.

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Section: Discussionmentioning

confidence: 99%

COVID-19 vaccination and the risk of autoimmune diseases: a Mendelian randomization study

Shan,

Hu,

Chen

et al. 2024

Front. Public Health

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“…We read with interest the article by Jeon et al 1 on a 19-year-old man with a history of unilateral optic neuritis, who died suddenly six months after SARS-CoV-2 vaccination with the second dose of the Biontech Pfizer vaccine (BPV). Autopsy revealed multifocal discoloration of the white matter, active and inactive demyelinating plaques around cortical and white matter veins, perivascular lymphocytic infiltration, and microglial proliferation.…”

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confidence: 99%

“…Autopsy revealed multifocal discoloration of the white matter, active and inactive demyelinating plaques around cortical and white matter veins, perivascular lymphocytic infiltration, and microglial proliferation. 1 The sudden death was attributed to laryngospasm or malignant ventricular arrhythmia (MVA) triggered by an end-stage seizure. 1 The study is excellent but has limitations that raise objections that should be discussed.…”

mentioning

confidence: 99%

“… 1 The sudden death was attributed to laryngospasm or malignant ventricular arrhythmia (MVA) triggered by an end-stage seizure. 1 The study is excellent but has limitations that raise objections that should be discussed.…”

mentioning

confidence: 99%

“…There is no mention that the patient met the Barkhof criteria. 1 Third, cerebrospinal fluid (CSF) findings after the first seizure were not indicative of multiple sclerosis. Aquaporin-4 antibodies were negative and myelin oligodendrocyte glycoprotein (MOG) antibodies have not been reported.…”

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confidence: 99%

See 2 more Smart Citations

Sudden Death Is More Likely to Result From SARS-COV-2 Infection Than Multiple Sclerosis

Finsterer

2023

J Korean Med Sci

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Withdrawn: A systematic review of autopsy findings in deaths after COVID-19 vaccination

Hulscher,

Alexander,

Amerling

et al. 2024

Forensic Science International

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Sudden Death Associated With Possible Flare-Ups of Multiple Sclerosis After COVID-19 Vaccination and Infection: A Case Report and Literature Review

Cited by 5 publications

References 29 publications

COVID-19 vaccination and the risk of autoimmune diseases: a Mendelian randomization study

COVID-19 vaccination and the risk of autoimmune diseases: a Mendelian randomization study

Sudden Death Is More Likely to Result From SARS-COV-2 Infection Than Multiple Sclerosis

Withdrawn: A systematic review of autopsy findings in deaths after COVID-19 vaccination

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