Sudden death in a foal due to Tyzzer’s disease: a case report

Haghighi, Zahra Minoosh Siavosh; Moaddab, H.; Safavi, Ehsan Allah Afshari; Moshaverinia, Ali; Miraghaii, Shahram

doi:10.1007/s00580-012-1670-8

Cited by 2 publications

(2 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…35 Two individual case reports described only hepatic lesions in foals. 1,11 In a retrospective study of 148 foals, TD was characterized primarily by hepatic lesions, with lesser involvement of the intestinal tract and rarely the myocardium, although no details of the pathologic findings in heart and colon were given. 30 Our results are consistent with previous reports in which the liver was the organ most frequently affected by TD in horses.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Clostridium piliforme infection (Tyzzer disease) in horses: retrospective study of 25 cases and literature review

et al. 2021

View full text Add to dashboard Cite

Tyzzer disease (TD) is caused by Clostridium piliforme, a gram-negative and obligate intracellular bacterium. The disease occurs in multiple species. A triad of lesions, namely colitis, hepatitis, and myocarditis, is described in cases of TD in some species, such as rats and mice. We carried out a retrospective analysis of 25 equine cases with a diagnosis of TD; 24 of 25 cases occurred in foals <45 d old; the remaining foal was 90 d old. There were 12 males and 12 females; no sex information was available for one foal. The affected breeds were Quarter Horse, Thoroughbred, Arabian, Paint, and Hanoverian. Most of the cases (19 of 25) occurred in the spring. There were 9 cases of sudden death; the remaining animals had diarrhea, fever, distended abdomen, depression, weakness, non-responsiveness, and/or recumbency. Gross findings included icterus, hepatomegaly with acinar pattern, serosal hemorrhages, pulmonary edema, and/or fluid content in small and large intestine. Microscopically, all foals had severe, multifocal, necrotizing hepatitis. Necrotizing lymphohistiocytic colitis was observed in 10 of 25 foals, and multifocal necrotizing myocarditis was found in 8 of 25. Gram-negative, Steiner-positive, intracytoplasmic filamentous bacteria were observed in hepatocytes, enterocytes, and myocardiocytes, respectively. PCR detected C. piliforme DNA in the liver (24 of 24), colon (20 of 24), and heart (5 of 25). Our results indicate that necrotic hepatitis is the hallmark of TD in horses; the so-called triad of lesions is not a consistent characteristic of the disease in this species.

show abstract

Section: Discussionmentioning

confidence: 99%

“…15,32,36 Most cases of TD in horses seem to affect the liver, and rarely the heart and colon. 3,11,21,30,35 However, information about the distribution of lesions in horses with TD is scant and, to our knowledge, there are no detailed descriptions of the distribution of C. piliforme in different tissues of horses with this disease.…”

mentioning

confidence: 99%