Sudden hearing loss as the initial symptom in Japanese patients with multiple sclerosis and seropositive neuromyelitis optica spectrum disorders

Tanaka, Masami; Tanaka, Keiko

doi:10.1016/j.jneuroim.2016.06.004

Cited by 18 publications

(12 citation statements)

References 17 publications

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“…The inner ear and brain are traditionally viewed as being immune privileged because there is a blood-labyrinthine barrier that acts in a similar manner as the blood-brain barrier, and only a few macrophages are present in these organs [ 1 ]. However, a large number of experimental and clinical cases of SSHL have been identified in which SSHL is a symptom associated with other autoimmune diseases or is the primary symptom of spontaneous systemic autoimmune diseases such as autoimmune hepatitis [ 2 ], sympathetic neural hyperalgesia edema syndrome [ 3 ], Cogan's syndrome [ 4 , 5 ], systemic lupus erythematosus [ 6 , 7 ], multiple sclerosis [ 8 – 10 ], rheumatoid arthritis [ 11 ], nodular polyarteritis [ 12 ], Crohn's disease [ 13 ], and so on. Increasing experimental evidence suggesting an autoimmune component in the pathology of SSHL has emerged since 1979 when McCabe first identified 18 patients with autoimmune-associated SSHL who were effectively medicated with glucocorticoid and vincristine [ 14 ].…”

Section: The Evidence For Autoimmunity In Sshlmentioning

confidence: 99%

The Role of Autoimmunity in the Pathogenesis of Sudden Sensorineural Hearing Loss

You

et al. 2018

Neural Plasticity

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Sudden sensorineural hearing loss (SSHL) is a clinically common acute symptom in otolaryngology. Although the incidence of SSHL has increased around the world in recent years, the etiology of the disease is still unclear. It has been reported that infections, ototoxic drugs, membrane labyrinth rupture, carcinomas, circulatory system diseases, autoimmune diseases, brain lesions, mental diseases, congenital or inherited diseases, and so on, are all risk factors for SSHL. Here, we discuss the autoimmune mechanisms behind SSHL, which might be induced by type II–IV allergic reactions. We also introduce the main immunosuppressive medications that have been used to treat SSHL, which will help us to identify potential targets for immune therapy.

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Section: The Evidence For Autoimmunity In Sshlmentioning

confidence: 99%

The Role of Autoimmunity in the Pathogenesis of Sudden Sensorineural Hearing Loss

You

et al. 2018

Neural Plasticity

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“…[298] Sensory symptoms such as numbness, dysesthesia, pain, and tonic spasms are well documented and neuropathic pruitis and sudden sensineurial hearing loss are also reported. [230262290308] Headache of several etiologies is reported and is another possible first-presenting symptom. [163] NMOSD patients are also at an increased risk of seizures.…”

Section: Symptoms Of Neuromyelitis Opticamentioning

confidence: 99%

Comprehensive review of neuromyelitis optica and clinical characteristics of neuromyelitis optica patients in Puerto Rico

Zarei¹,

Eggert²,

Franqui-Dominguez³

et al. 2018

Surg Neurol Int

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Neuromyelitis optica (NMO) is an immune-mediated inflammatory disorder of the central nervous system. It is characterized by concurrent inflammation and demyelination of the optic nerve (optic neuritis [ON]) and the spinal cord (myelitis). Multiple studies show variations in prevalence, clinical, and demographic features of NMO among different populations. In addition, ethnicity and race are known as important factors on disease phenotype and clinical outcomes. There are little data on information about NMO patients in underserved groups, including Puerto Rico (PR). In this research, we will provide a comprehensive overview of all aspects of NMO, including epidemiology, environmental risk factors, genetic factors, molecular mechanism, symptoms, comorbidities and clinical differentiation, diagnosis, treatment, its management, and prognosis. We will also evaluate the demographic features and clinical phenotype of NMO patients in PR. This will provide a better understanding of NMO and establish a basis of knowledge that can be used to improve care. Furthermore, this type of population-based study can distinguish the clinical features variation among NMO patients and will provide insight into the potential mechanisms that cause these variations.

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“…3 In all, 90% of HLs in SSHL cases were unilateral, and age was mostly from 40 to 60 years. 4 Many studies showed the SSHL was involved in some autoimmune diseases or was the primary symptom of spontaneous systemic autoimmune diseases such as systemic lupus erythematosus, 5 multiple sclerosis, 6 and Crohn disease. 7,8 For these patients with SSHL, timely treatment was important.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Steroid Treatment for Sudden Sensorineural Hearing Loss: A Meta-analysis of Randomized Controlled Trials

Ding

2020

Ann Pharmacother

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Background: The best way to administer steroids for sudden sensorineural hearing loss (SSHL) is still unclear. The present study was aimed at estimating the efficacy of steroids by intratympanic, systemic, and combined therapy (CT) routes. Methods: A systematic literature search was performed from 1950 to October 2019 for randomized controlled trials comparing the use of intratympanic, systemic, and combined steroid therapy for SSHL. The outcomes of recovery rate and pure tone average (PTA) improvement were assessed by random-effects and fixed-effects meta-analysis. Results: A total of 20 articles identified from 7 countries were eligible for analysis. Although no significant difference in recovery rate was observed between intratympanic steroid therapy (IST) and systemic steroid therapy (SST), IST did demonstrate better hearing improvement, as evidenced by a higher PTA than SST. Compared with SST, CT comprising IST and SST had significant recovery rate improvement. Patients treated with CT had a significantly higher PTA than those treated with SST. Through subgroup analysis based on the equivalent dose of prednisone, it was shown that CT led to a significantly higher PTA than SST only in the high-dose CT versus high-dose SST groups and moderate-dose CT versus high-dose SST groups. Conclusion: Moderate and high dose of CT could accelerate hearing improvement in SSHL.

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Sudden hearing loss as the initial symptom in Japanese patients with multiple sclerosis and seropositive neuromyelitis optica spectrum disorders

Cited by 18 publications

References 17 publications

The Role of Autoimmunity in the Pathogenesis of Sudden Sensorineural Hearing Loss

The Role of Autoimmunity in the Pathogenesis of Sudden Sensorineural Hearing Loss

Comprehensive review of neuromyelitis optica and clinical characteristics of neuromyelitis optica patients in Puerto Rico

Effectiveness of Steroid Treatment for Sudden Sensorineural Hearing Loss: A Meta-analysis of Randomized Controlled Trials

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