Sudden Sensorineural Hearing Loss

Alexiou, Christoph; Arnold, W.; Fauser, C.; Schratzenstaller, Bruno; Gloddek, B.; Fuhrmann, S.; Lamm, Kerstin

doi:10.1001/archotol.127.3.253

Cited by 96 publications

(10 citation statements)

References 25 publications

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“…There was a clear trend towards improved outcome in patients receiving high-dose steroids, but, no significant relationship. The question if steroids or the dose of the administered steroids have important influence on hearing recovery remains controversial [21–23, 29, 44, 55–57]. …”

Section: Discussionmentioning

confidence: 99%

Predictors of hearing recovery in patients with severe sudden sensorineural hearing loss

Weiß

Böcker

Koopmann³

et al. 2017

Journal of Otolaryngology - Head & Neck Surgery

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BackgroundSudden sensorineural hearing loss (SSHL) is a disease, which severely affects the patient’s social and relational life. The underlying pathomechanisms have not been finally clarified yet and outcome is not predictable.MethodsWe conducted a retrospective study in order to identify parameters that influence hearing recovery. The data base contains results of basic otoneurological tests and clinical parameters of 198 patients with idiopathic SSHL of at least 60 dB in at least four frequencies, diagnosed and treated at the University Hospital of Münster, Germany, between 1999 and 2015. Hearing recovery was measured by pure tone audiometry.ResultsMultivariate linear and logistic regression analyses indicate that the chance as well as the magnitude of hearing recovery is higher for patients with normal caloric testing than for patients with pathological caloric testing. However, for the subgroup of patients who attained a hearing recovery, the caloric testing result was not found to influence the magnitude. Instead, the magnitude was noticeably lower for patients within this subgroup who had a previous hearing loss. Furthermore, we found indications that the magnitude is higher for men than for women and that receiving a high-dose steroid therapy is associated with a higher chance and magnitude of a hearing recovery.ConclusionsWe conclude that SSHL associated with disorders of the vestibular system or previous hearing loss represent special sub-entities of SSHL that may be caused by unique pathophysiological mechanisms and are associated with worse outcome. Furthermore, our data support the importance of elevated dosage of steroids in SSHL therapy.

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Section: Discussionmentioning

confidence: 99%

Predictors of hearing recovery in patients with severe sudden sensorineural hearing loss

Weiß

Böcker

Koopmann³

et al. 2017

Journal of Otolaryngology - Head & Neck Surgery

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show abstract

“…Corticosteroids might cause anti-inflammatory and metabolic effects, and alter the immune response [15]. With prolonged use of systemic steroids, significant adverse reactions such as abnormal liver function, gastrointestinal trouble, avascular necrosis, epistaxis, acne, and gluteal abscess can occur [916]. …”

Section: Discussionmentioning

confidence: 99%

Comparative Analysis of the Combined Therapeutic Effects of Lipoprostaglandin E1 on Sudden Idiopathic Sensorineural Hearing Loss

Shim

Kim

2017

J Audiol Otol

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Background and ObjectivesViral and vascular disorders are considered to be a major cause of idiopathic sudden sensorineural hearing loss (ISSNHL). Lipoprostaglandin E1 (lipo-PGE1) has vasodilating activity and has been used to treat ISSNHL. The purpose of this study was to determine the specific therapeutic effects of lipo-PGE1 and compare them to other treatment modalities for ISSNHL.Subjects and MethodsThe study group had 1,052 patients diagnosed with ISSNHL. All were treated with steroid, carbogen inhalation, stellate ganglion block (SGB), or PGE1. The CP group (steroid, carbogen inhalation, and PGE1 injection; 288 patients) was treated with lipo-PGE1 and carbogen inhalation, the CS group (steroid, carbogen inhalation, and stellate ganglion block; 232 patients) with steroid, carbogen inhalation, and SGB, the C group (steroid and carbogen inhalation; 284 patients) with steroid and carbogen, and the control group (steroid only; 248 patients) with steroid only. Patients in the groups receiving lipo-PGE1 received a continuous infusion of 10 µL lipo-PGE1.ResultsThe overall recovery rate after treatment was 52.2%, and recovery rates by group were 67.7% in the CP group, 54.3% in the CS group, 52.1% in the C group, and 32.2% in the control group. Therefore, the therapeutic results in groups treated with lipo-PGE1 were better than results in other groups. The difference was statistically significant.ConclusionsThe study results suggested that the CP group received effective treatment modalities for ISSNHL. The combined therapy of lipo-PGE1 with carbogen inhalation in patients with ISSNHL was more beneficial than other treatment modalities.

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“…diabetics, and ruptured round window membrane (in the glucocorticoid group) [4]. These were serious flaws significantly jeopardizing the validity of results.…”

Section: Discussionmentioning

confidence: 99%

Steroid Use in Idiopathic Sudden Sensorineural Hearing Loss: What is the Evidence?

Gheriani¹,

Mh²,

Da³

2008

Libyan J Med

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Sudden Sensorineural Hearing Loss

Abstract: Administration of glucocorticoids should be recommended for treatment of patients with SSNHL. In particular, patients with SSNHL in the lower and middle frequency range and pancochlear hearing loss have significantly better recovery of hearing levels.

Cited by 96 publications

References 25 publications

Predictors of hearing recovery in patients with severe sudden sensorineural hearing loss

Predictors of hearing recovery in patients with severe sudden sensorineural hearing loss

Comparative Analysis of the Combined Therapeutic Effects of Lipoprostaglandin E1 on Sudden Idiopathic Sensorineural Hearing Loss

Steroid Use in Idiopathic Sudden Sensorineural Hearing Loss: What is the Evidence?

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