Sudden Sensorineural Hearing Loss in Lupus Erythematosus Associated with Antiphospholipid Syndrome: Case Report and Review

Compadretti, Giacomo Ceroni; Brandolini, Cristina; Tasca, Ignazio

doi:10.1177/000348940511400308

Cited by 36 publications

(26 citation statements)

References 21 publications

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“…Researchers have also speculated on the existence of a strong relationship between the presence of anticardiolipin antibodies, often found in patients with SLE, and sudden SNHL. 2 27 29 In such cases, the authors argue that the formation of microthrombus in cochlear vessels could be the etiology of sudden SNHL. …”

Section: Discussionmentioning

confidence: 99%

Sudden Sensorioneural Hearing Loss and Autoimmune Systemic Diseases

Rossini

Penido

Munhoz

et al. 2016

Int Arch Otorhinolaryngol

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Introduction Several authors have demonstrated the relationship between sudden sensorineural hearing loss (SNHL) and systemic autoimmune diseases (SAD). Immune-mediated SNHL can rarely present as unilateral sudden SNHL and manifests itself in the contralateral ear only after years. It presents clinical relevance for being one of the few SNHL that may be reversible given that early and appropriate treatment is applied. Objective The objective of this study is to describe the clinical presentations and audiological findings from patients with idiopathic sudden SNHL and SAD associated with a probable diagnosis of immune-mediated SNHL. Furthermore, we strive to estimate the prevalence of SAD in patients with sudden SNHL. Methods This is an observational retrospective cohort. We have selected and studied patients with SAD. Revision of available literature on scientific repositories. Results We evaluated 339 patients with sudden SNHL. Among them, 13 (3.83%) patients suffered from SAD. Three patients had bilateral involvement, a total of 16 ears. We evaluate and describe various clinical, epidemiological, and audiological aspects of this sample. Conclusion In our sample of patients with sudden SNHL, the prevalence of SAD was found relevant. The majority had tinnitus and dizziness concomitant hearing loss, unilateral involvement and had experienced profound hearing loss at the time of the installation. In spite of instituted treatment, most cases showed no improvement in audiometric thresholds. Apparently, patients with sudden SNHL and SAD have a more severe initial impairment, higher percentage of bilateral, lower response to treatment, and worse prognosis than patients with sudden SNHL of unknown etiology.

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Section: Discussionmentioning

confidence: 99%

Sudden Sensorioneural Hearing Loss and Autoimmune Systemic Diseases

Rossini

Penido

Munhoz

et al. 2016

Int Arch Otorhinolaryngol

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“…20 Nevertheless, Compadretti et al 7 reported the case of a patient who received hydroxychloroquine therapy for three years but did not show any signs of cochlear damage.…”

Section: Discussionmentioning

confidence: 99%

Young systemic lupus erythematosus patients with no hearing involvement: 10-year follow up

et al. 2012

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These results supply no evidence for progressive hearing loss in systemic lupus erythematosus patients with no hearing involvement at study commencement. Therefore, we recommend audiometric tests only for systemic lupus erythematosus patients complaining of hearing loss, or for other clinical purposes. It is conceivable that asymptomatic hearing loss could be observed over a more extended follow-up period (i.e. more than 10 years).

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“…Apabila vaskulitis terdapat pada arteri labirin dan cabangnya pada penderita LES, keadaan tersebut mengakibatkan gangguan pada pendengaran. [3][4][5] Kerusakan telinga pada pasien LES sudah banyak dilaporkan. Pada penelitian di Polandia pada tahun 2009 terhadap 35 pasien LES, dari pemeriksaan brainstem evoked respons auditory (BERA) didapatkan bahwa 10 orang mengalami gangguan dengar sensorineural secara simetris pada frekuensi tinggi.…”

Section: Pendahuluanunclassified

Pengaruh Prednison terhadap Perbaikan Pendengaran Penderita Lupus Eritematosus

Wijana¹,

Mutiara²,

Agustian³

2016

mkb

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AbstrakLupus eritematosus sistemik (LES) merupakan penyakit kronik mengenai multisistem, merupakan gangguan autoimun yang ditandai oleh produksi autoantibodi dan deposisi kompleks imun di jaringan. Manifestasi klinis dapat meliputi berbagai organ termasuk telinga. Pada telinga dapat menimbulkan gangguan dengar, tinitus, dan vertigo. Gangguan dengar terjadi bilateral pada frekuensi tinggi. Prednison merupakan kortikosteroid oral yang memiliki efek glukokortikoid yang bersifat anti-inflamasi dan imunosupresif. Penelitian ini bertujuan mengetahui pengaruh prednison terhadap perbaikan pendengaran penderita LES. Penelitian dilakukan periode Maret-Mei 2013 di Poliklinik Gangguan Dengar dan Bicara, Telinga Hidung Tenggorok Bedah Kepala dan Leher Rumah Sakit Dr. Hasan Sadikin Bandung menggunakan metode quasi-experimental dengan rancangan one group pretestposttest design dan hasilnya dihitung secara statistik menggunakan uji Rank Spearman. Pada 28 subjek pasien LES dilakukan anamnesis, pemeriksaan fisis, laboratorium, audiometri nada murni, timpanometri, dan distortion production otoacoustic emissions. Subjek diberi prednison 1 mg/kgBB/hari (dosis maksimal 60 mg/hari) selama 4 minggu, kemudian dilakukan evaluasi ulang. Sebelum terapi, 26 subjek mengalami gangguan dengar sedang pada frekuensi tinggi, simetris. Sesudah terapi, 24 subjek ambang dengar menjadi normal dan 4 subjek tetap mengalami gangguan dengar (Rs=0,734; p<0,01 Prednisone Effect to on Hearing Status of Systemic Lupus Erythematosus Patients AbstractSystemic lupus erythematosus (SLE) is a chronic, multi-system, autoimmune disorder characterized by the production of autoantibodies and immune complexes deposition in tissue. Clinical manifestations may include skin, mucosa, joints, blood, heart, lungs, kidneys, central nervous system (CNS), immune system, and ears. SLE Iin the ears can caused sensorineural hearing loss, tinnitus, and vertigo. This hearing disorder is commonly bilateral and has high frequencies. Prednisone is an oral corticosteroid with glucocorticoid and mineralocorticoid effects. Glucocorticoids have anti-inflammatory and immunosuppressive effects. The aim of this study was to evaluate the effect of prednisone in improving the degree of hearing loss in patients with SLE. This study was conducted in from March-May 2013, at tThe Hearing and Speech Disorder Clinic of Ear Nose Throat-Head and Neck Surgery, Dr. Hasan Sadikin Hospital Bandung, using quasi-experimental method with pre-post design in which the results were statistically calculated using Rank Spearman test. This study involved 28 subjects who had been diagnosed for SLE. Anamnesis, physical examination, and laboratory test were performed, followed by pure tone audiometry, tympanometry, and distortion product optoacoustic emissions (DPOAE). Subjects were given prednisone 1 mg/kgBW/day with a maximum dose of 6o mg/day. Re-evaluation was performed after 4 weeksof treatment. Before treatment, 26 subjects had mild hearing loss and 2 subjects had symmetric moderate hearing loss at high freque...

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Sudden Sensorineural Hearing Loss in Lupus Erythematosus Associated with Antiphospholipid Syndrome: Case Report and Review

Cited by 36 publications

References 21 publications

Sudden Sensorioneural Hearing Loss and Autoimmune Systemic Diseases

Sudden Sensorioneural Hearing Loss and Autoimmune Systemic Diseases

Young systemic lupus erythematosus patients with no hearing involvement: 10-year follow up

Pengaruh Prednison terhadap Perbaikan Pendengaran Penderita Lupus Eritematosus

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