Sudden sensorineural hearing loss in a patient with primary antiphospholipid syndrome

Kt, Kang; Young, YH

doi:10.1017/s0022215107007736

Cited by 15 publications

(5 citation statements)

References 18 publications

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“…10 Autoimmune diseases such as the primary antiphospholipid syndrome also seem to be associated with SSNHL. 11 The endothelium plays a major role in this initial stage of vascular disease. Endothelial dysfunction is characterized by an increased production of cytokines in addition to an elevated expression of adhesion molecules.…”

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confidence: 99%

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The Role of Soluble Adhesion Molecules and Cytokines in Sudden Sensorineural Hearing Loss

Haubner

Martin

Steffens

et al. 2011

Otolaryngol.--head neck surg.

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This study revealed no association concerning SSNHL and typical vascular risk factors such as lipids and fibrinogen. Soluble adhesion molecules were not elevated in the SSNHL group. The role of endothelial dysfunction represented by increased levels of soluble adhesion molecules in the pathogenesis of SSNHL remains unclear. Further studies are necessary to elucidate the vascular etiology of SSNHL.

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confidence: 99%

“…Autoimmune diseases such as the primary antiphospholipid syndrome also seem to be associated with SSNHL 11 . The endothelium plays a major role in this initial stage of vascular disease.…”

mentioning

confidence: 99%

The Role of Soluble Adhesion Molecules and Cytokines in Sudden Sensorineural Hearing Loss

Haubner

Martin

Steffens

et al. 2011

Otolaryngol.--head neck surg.

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“…4–7 SNHL has been linked to APS. 14,16–19 Case reports have indicated a connection between APS and neuronal hearing loss. High antibody titres have been found in patients with unilateral or bilateral SNHL.…”

Section: Discussionmentioning

confidence: 99%

“…reported an association between anticardiolipin antibodies (aCL) and SNHL in a girl with SLE. 14 Since then, SNHL has been linked sporadically to APS, primarily in case reports, 15–17 while prospective clinical studies examining SNHL among APS patients are sparse. Moreover, many of the studies addressing the relationship between antiphospholipid antibodies (aPL) and SNHL involved SLE patients and not primary APS patients or examined the prevalence of aPL antibodies per se in patients with SNHL.…”

Section: Introductionmentioning

confidence: 99%

Audiological disturbances in patients with primary antiphospholipid syndrome

Erez

Abarbuch

Natour

et al. 2020

Lupus

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Background Antiphospholipid syndrome (APS) is an autoimmune disease of hypercoagulability state in the presence of antibodies against phospholipids. Many neurological deficits related to APS have been described. Sensory neural hearing loss has been described only anecdotally, mostly in case reports. This study investigated a possible association between hearing disorders and APS. Methods Seventeen patients (aged 20–80 years) diagnosed with primary APS were evaluated for evidence of hearing disorders. All had otoscopy, full audiometry test, brainstem evoked response audiometry and otoacoustic emissions testing, and completed a questionnaire. Hearing levels were compared to the standard hearing levels of the general population by age group. Results Of the 17 APS patients, 10 (age groups 20–29 and 50–59) had significantly reduced hearing levels in all or part of the tested frequencies compared to standard levels. Three patients (age group 60–69) had better hearing levels at low frequencies compared to standard hearing levels. Conclusion These findings support the existence of hearing disorders in primary APS.

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“…An etiology can be identified in only one-third of cases (in decreasing order of frequency: infectious, otologic, traumatic, hematologic, neoplastic), and most SSNHL cases are idiopathic [ 9 ]. The pathophysiological mechanisms underlying the onset of idiopathic SSNHL have been described as viral [ 10 , 11 ], vascular [ 12 , 13 ], pressure-related [ 14 , 15 ], autoimmune [ 16 , 17 ], and genetic [ 18 , 19 ]. It has been reported that examining vestibular organ functions in subjects suffering from SSNHL could help identify its etiopathogenesis [ 20 ].…”

Section: Available Epidemiological Data On Sudden Sensorineural Heari...mentioning

confidence: 99%

Sudden Sensorineural Hearing Loss after COVID-19 Vaccination: A Review of the Available Evidence through the Prism of Causality Assessment

Thai-Van,

Bagheri,

Valnet-Rabier

2024

Vaccines

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Sudden sensorineural hearing loss (SSNHL), a rare audiological condition that accounts for 1% of all cases of sensorineural hearing loss, can cause permanent hearing damage. Soon after the launch of global COVID-19 vaccination campaigns, the World Health Organization released a signal detection about SSNHL cases following administration of various COVID-19 vaccines. Post-marketing studies have been conducted in different countries using either pharmacovigilance or medico-administrative databases to investigate SSNHL as a potential adverse effect of COVID-19 vaccines. Here, we examine the advantages and limitations of each type of post-marketing study available. While pharmacoepidemiological studies highlight the potential association between drug exposure and the event, pharmacovigilance approaches enable causality assessment. The latter objective can only be achieved if an expert evaluation is provided using internationally validated diagnostic criteria. For a rare adverse event such as SSNHL, case information and quantification of hearing loss are mandatory for assessing seriousness, severity, delay onset, differential diagnoses, corrective treatment, recovery, as well as functional sequelae. Appropriate methodology should be adopted depending on whether the target objective is to assess a global or individual risk.

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Sudden sensorineural hearing loss in a patient with primary antiphospholipid syndrome

Abstract: Consensus exists on the effectiveness of anticoagulant agents in aiding a favourable outcome of sudden sensorineural hearing loss in patients with antiphospholipid syndrome.

Cited by 15 publications

References 18 publications

The Role of Soluble Adhesion Molecules and Cytokines in Sudden Sensorineural Hearing Loss

The Role of Soluble Adhesion Molecules and Cytokines in Sudden Sensorineural Hearing Loss

Audiological disturbances in patients with primary antiphospholipid syndrome

Sudden Sensorineural Hearing Loss after COVID-19 Vaccination: A Review of the Available Evidence through the Prism of Causality Assessment

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