Sudden Sensorineural Hearing Loss in Children—Management and Outcomes: A Meta‐analysis

Wood, Joshua; Shaffer, Amber D.; David, Helena Maria Scherlowski Leal

doi:10.1002/lary.28829

Cited by 28 publications

(33 citation statements)

References 30 publications

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“…However, a relevant predictor of poor improvement appeared to be profound hearing loss. Sex was not significantly associated with occurrence risk and hearing prognosis, 2,5,9,10,[12][13][14] whereas in the adult population it seemed to be relevant. 35,36 A recent systematic review and meta-analysis on pediatric sudden sensorineural hearing loss considered children with identified causes of hearing loss.…”

Section: Discussionmentioning

confidence: 75%

Idiopathic Sudden Sensorineural Hearing Loss in Children: A Systematic Review and Meta‐analysis

Franz

Gallo

Filippis

et al. 2020

Otolaryngol.--head neck surg.

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Objective Idiopathic sudden sensorineural hearing loss (ISSNHL) is uncommon in children, and its treatment and outcome are debated. We aimed to critically review evidence in the literature about treatment options and functional outcomes of pediatric ISSNHL. Additionally, we performed a meta-analysis of the results of combined systemic-intratympanic steroid therapy versus solely systemic treatment. Data Sources A search was run in the PubMed, Scopus, and Google Scholar databases. Review Methods Included articles were original ISSNHL case series, written in English, with a population age ranging from 2 to 19 years. Other study types (single case reports, editorials, and reviews) and case series with known etiology of sudden hearing loss were excluded. Descriptive data of patients, treatments, outcomes, and possible prognostic factors were extracted and recorded for every included study. Results Twelve articles (7 cohort and 5 case-control studies) met all the selection criteria. Based on only the studies that provided sufficient data about clinical outcome, the pooled overall recovery rate was 67.91% (95% CI, 58.34%-77.48%). No studies showed a significant difference between systemic steroid and combined systemic-intratympanic steroid. The pooled odds ratio for combined systemic-intratympanic steroid versus systemic steroid alone was 0.90 (95% CI, 0.36-2.27) based on a random effects model, ruling out any significant difference between these treatment options. Conclusions The results of our meta-analysis did not support combination therapy more than systemic steroid alone. Further prospective clinical trials are necessary to establish evidence-based therapies.

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Section: Discussionmentioning

confidence: 75%

Idiopathic Sudden Sensorineural Hearing Loss in Children: A Systematic Review and Meta‐analysis

Franz

Gallo

Filippis

et al. 2020

Otolaryngol.--head neck surg.

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“…91 Niños: Si bien se plantea iniciar con corticoides tal como en adultos, Woods y cols (2020) demostraron que a pesar del tratamiento con corticoides sean orales o intratimpánicos no existió mejoría del perfil auditivo. 99…”

Section: Los Esquemas Usados Incluyenunclassified

“…En niños especialmente: traumáticas, colesteatoma congénito, displasia del nervio coclear, infección del oído interno, citomegalovirus (CMV) y parotiditis. 99 Específicamente en relación a la hipoacusia neurosensorial súbita idiopática, se han planteado numerosas líneas de tratamiento entre ellas: corticoides, antivirales, antioxidantes, vitaminas, agentes vasoactivos, vasodilatadores, oxígeno hiperbárico, calcio antagonista, timpanostomía, neurorehabilitación, acupuntura, medicina oriental, células madre, implante coclear, entre otros; sin evidencia concluyente hasta el momento. 42 El consenso SEORL 201837 y la guía AAO-HNS 201914 plantean iniciar con prednisona oral, además el uso de dexametasona oral, parenteral o intratimpánica.…”

Section: Introductionunclassified

Hipoacusia neurosensorial súbita, el gran dilema de la otorrinolaringología. Una revisión de la literatura

Montúfar¹,

Tobar²

2020

RECIMUNDO

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Introducción La hipoacusia neurosensorial súbita es una emergencia otorrinolaringológica descrita desde 1944 y que continúa siendo un gran enigma. El objetivo es resumir e identificar los aspectos relevantes, avances y futuras perspectivas acerca del tema Metodología: Se realizó una revisión de literatura usando los motores de búsqueda de MEDLINE y Google académico de los últimos 5 años. Resultados: Es de causa idiopática en el 85% a 90%, con presentación bilateral en 0,4 a 3,4%, se han planteado numerosas teorías etiológicas entre ellas: vascular, inmunológica, estrés oxidativo, autoinmune, fístula perilinfática, traumáticas, viral, tumoral,entre otros, y en relación a ellas, numerosas líneas de tratamiento sin evidencia concluyente hasta el momento. Discusión: Frente a este cuadro clínico, se debe actuar inmediatamente; en el diagnóstico es importante la diferenciación con hipoacusia secundaria, la detección de signos de alarma, la forma de presentación y la severidad de la hipoacusia. No existe al momento un consenso global sobre su manejo, sin embargo, se recomienda iniciar con corticoterapia de manera inmediata, El uso de otras terapias aún se encuentra en debate, parecería tener evidencia prometedora el uso adyuvante con corticoides de vasodilatadores (PGE1), calcio antagonistas y acupuntura. La terapia de rescate parecería ser prometedora con el uso de oxígeno hiperbárico y corticoides intratimpánicos. Se han planteado otras terapias a futuro, buscando la estimulación de la regeneración de cilios celulares, o el reemplazo con células madre, sin embargo, estas terapias son conceptuales y aun no se han comprobado en estudios experimentales.

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“…Otitis media, sudden sensorineural hearing loss (SSHL), tinnitus, presbycusis, autoimmune inner ear ailment, serious inner ear infections caused by bacteria and virus and Meniere's disease affect substantial portion of world population at any stage of life cycle/regardless of their age. [1][2][3][4] Heredity. [5][6] age factors, [7][8] autoimmune disorders, [9][10] pathogen (viral, bacterial, and fungal), [11][12][13][14][15] environmental factors (exposure to excessive noise and radiation), [16][17] increase in life expectancy, chemotherapeutic drugs induced ototoxic [18][19] are the main cause for the most of the disorders in the otic region.…”

Section: Introductionmentioning

confidence: 99%

An Overview of Nanoparticle Drug Delivery for Ototoxin and Noise Mediated Hearing Loss Treatment

Sreeharsha¹,

Nataraj²,

Jang³

et al. 2022

Ind. J. Pharm. Edu. Res

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Efficient delivery of therapeutic material to target site of the inner ear is considered as the most challenging process due to their poor blood flow and inaccessibility sensitivity towards chemical stimuli, inability of drug to be delivered as well. Novel nanoparticlebased drug transport approaches have emerged for overcoming the restriction associated with inner ear therapeutic material delivery. The main focus of this article is to highlight the potential benefits, pre-clinical level otoprotective effect of different types of NPs based payload delivery strategies in mitigating sensorineural hearing impairment resulting from medication (cisplatin and antibiotic treatment) and noise exposure. This review converses about advantage of nanocarrier assisted targeted cell specific inner ear drug delivery approach and demonstrates that targeted NPs delivery systems have the capability to be utilized as vehicle to transport therapeutic materials into the OHCs within the cochlea in controlled and sustained way and maximize following therapeutic effects. Efficacy of systemic and minimally invasive intratympanic and RWM approach for delivering steroids/ genetic material to the inner ear has also been compared in this article. Understanding the importance (design, formulation, cochlear biocompatibility and cell specific binding efficiency of NPs, mechanistic pathways, route of delivery, positive therapeutic outcomes) and hitches (adverse effects after treatment, negative therapeutic outcome) of currently available NPs based drug delivery systems offer new opportunity to develop best treatment methods for sensorineural hearing dysfunction.

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Sudden Sensorineural Hearing Loss in Children—Management and Outcomes: A Meta‐analysis

Cited by 28 publications

References 30 publications

Idiopathic Sudden Sensorineural Hearing Loss in Children: A Systematic Review and Meta‐analysis

Idiopathic Sudden Sensorineural Hearing Loss in Children: A Systematic Review and Meta‐analysis

Hipoacusia neurosensorial súbita, el gran dilema de la otorrinolaringología. Una revisión de la literatura

An Overview of Nanoparticle Drug Delivery for Ototoxin and Noise Mediated Hearing Loss Treatment

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