Sudden sensorineural hearing loss: Is antiviral treatment really necessary?

Övet, Gültekin; Alataş, Necat; Kocacan, Fatma Nur; Gürcüoğlu, Sermin Selver; Görgülü, Hakan; Güzelkara, Fatih; Övet, Habibe

doi:10.1016/j.amjoto.2015.02.011

Cited by 4 publications

(3 citation statements)

References 26 publications

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“…The therapeutic role of corticosteroids and/or corticosteroids with antiviral agents for SSNHL has not been fully proven yet, although corticosteroids are known to alleviate hearing loss and reduce cochlear damage in patients receiving this treatment by strongly suppressing immune-mediated inflammatory reactions [32,38,39]. Acyclovir and valacyclovir, two anti-herpes virus medications commonly used to treat HZ, are efficacious only against HSV and VZV, but have not been proven to be efficacious against SSNHL and may cause ototoxicity [32,38,[40][41][42]. Although the first two drugs did not show a clear effect on short-term hearing restoration after a diagnosis of SSNHL, they may have reduced the long-term course or deterioration.…”

Section: Discussionmentioning

confidence: 99%

Effect of Herpes Zoster Treatment and Sudden Sensorineural Hearing Loss Using National Health Insurance Claims Data of South Korea

et al. 2023

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Background and objectives: Herpes zoster (HZ) is caused by the reactivation of a pre-existing latent varicella zoster virus, which is one of the viruses that causes hearing loss, and hearing loss may occur due to a systemic immune response even if it does not invade the auditory nerve. This study aimed to determine the correlation between sudden sensorineural hearing loss (SSNHL) in older adult patients who received HZ treatment. Materials and Methods: We used the cohort data of patients aged 60 years and above (n = 624,646) between 2002 and 2015 provided by the National Health Insurance Service. The patients were divided into two groups: those who were diagnosed with HZ between 2003 and 2008 (group H, n = 36,121) and those who had not been diagnosed with HZ between 2002 and 2015 (group C, n = 584,329). Results: In the main model (adjusted HR = 0.890, 95% CI = 0.839–0.944, p < 0.001) adjusted for sex, age, and income, and the full model (adjusted HR = 0.894, 95% CI = 0.843–0.949, p < 0.001) adjusted for all comorbidities, group H had a lower risk of SSNHL than group C. Conclusions: This study showed that patients who received HZ treatment had a lower incidence of SSNHL within five years after diagnosis.

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Section: Discussionmentioning

confidence: 99%

Effect of Herpes Zoster Treatment and Sudden Sensorineural Hearing Loss Using National Health Insurance Claims Data of South Korea

et al. 2023

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“…Se han atribuido varios agentes virales como causa de HNSS como adenovirus, arenavirus, herpes virus rubeola, VIH, entre otros, ya sea por invasión directa (parotiditis), reactivación viral (VVZ) o inmunomediado (CMV con cambios en el ganglio espiral). 18,72 Sin embargo hasta el momento en adultos ningún antiviral ha demostrado tener eficacia en el tratamiento de hipoacusia neurosensorial súbita, así lo ha demostrado en revisiones sistemáticas y meta análisis realizados, el último en el 2012. 4 En niños, se establece la asociación con CMV e hipoacusia neurosensorial súbita: la asociación más frecuentemente encontrada fue de inicio tardío y progresiva32.…”

Section: A Antiviralesunclassified

Hipoacusia neurosensorial súbita, el gran dilema de la otorrinolaringología. Una revisión de la literatura

Montúfar¹,

Tobar²

2020

RECIMUNDO

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Introducción La hipoacusia neurosensorial súbita es una emergencia otorrinolaringológica descrita desde 1944 y que continúa siendo un gran enigma. El objetivo es resumir e identificar los aspectos relevantes, avances y futuras perspectivas acerca del tema Metodología: Se realizó una revisión de literatura usando los motores de búsqueda de MEDLINE y Google académico de los últimos 5 años. Resultados: Es de causa idiopática en el 85% a 90%, con presentación bilateral en 0,4 a 3,4%, se han planteado numerosas teorías etiológicas entre ellas: vascular, inmunológica, estrés oxidativo, autoinmune, fístula perilinfática, traumáticas, viral, tumoral,entre otros, y en relación a ellas, numerosas líneas de tratamiento sin evidencia concluyente hasta el momento. Discusión: Frente a este cuadro clínico, se debe actuar inmediatamente; en el diagnóstico es importante la diferenciación con hipoacusia secundaria, la detección de signos de alarma, la forma de presentación y la severidad de la hipoacusia. No existe al momento un consenso global sobre su manejo, sin embargo, se recomienda iniciar con corticoterapia de manera inmediata, El uso de otras terapias aún se encuentra en debate, parecería tener evidencia prometedora el uso adyuvante con corticoides de vasodilatadores (PGE1), calcio antagonistas y acupuntura. La terapia de rescate parecería ser prometedora con el uso de oxígeno hiperbárico y corticoides intratimpánicos. Se han planteado otras terapias a futuro, buscando la estimulación de la regeneración de cilios celulares, o el reemplazo con células madre, sin embargo, estas terapias son conceptuales y aun no se han comprobado en estudios experimentales.

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“…3,4 Because of the relatively low incidence of SSNHL, neither its etiology nor adequate therapy can be determined with certainty. The most commonly suspected etiologies of SSNHL include viral infection, 5 vascular occlusion, 6 abnormal cellular stress responses within the cochlea, 7 and immune-mediated mechanisms. 8 Many studies that have proposed a possible association between viral infection and SSNHL; [9][10][11] the virus species in these studies include herpes simplex virus (HSV), HIV, hepatitis virus, measles virus, rubella virus, mumps virus, Lassa virus, and enterovirus.…”

Section: Introductionmentioning

confidence: 99%

Role of viral infection in sudden hearing loss

Chen

Zhang

2019

J Int Med Res

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According to a recent epidemiological survey, the incidence of sudden sensorineural hearing loss (SSNHL) is increasing yearly. The cause of SSNHL is of great interest in research. To date, viral infection, vascular occlusion, abnormal cellular stress responses within the cochlea, and immune-mediated mechanisms are considered the most likely etiologies of this disease. Among these etiologies, the relationship between viral infection and sudden deafness has been unclear. In this review, we mainly discuss the viral hypothesis of SSNHL. There is little research proving or clearly indicating the pathogenesis of this disease. Further research is needed to elucidate the precise etiopathogenesis to better understand SSNHL and establish more suitable treatment to help restore hearing in affected patients.

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Sudden sensorineural hearing loss: Is antiviral treatment really necessary?

Cited by 4 publications

References 26 publications

Effect of Herpes Zoster Treatment and Sudden Sensorineural Hearing Loss Using National Health Insurance Claims Data of South Korea

Effect of Herpes Zoster Treatment and Sudden Sensorineural Hearing Loss Using National Health Insurance Claims Data of South Korea

Hipoacusia neurosensorial súbita, el gran dilema de la otorrinolaringología. Una revisión de la literatura

Role of viral infection in sudden hearing loss

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