Sudden sensorineural hearing loss with end-stage renal disease: a report of 32 cases

Wang, Xiangsheng; Jiang, Ruirui; Su, Jian

doi:10.1080/00016489.2019.1659516

Cited by 8 publications

(11 citation statements)

References 17 publications

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“…Our results are consistent with those of a previous report that demonstrated that patients with ISSHL undergoing HD did not have a worse hearing prognosis. 8 As the results of our study indicate that HD does not interfere with the treatment outcomes of ISSHL, standard treatment, using mainly corticosteroid tapering and vasodilators, should be conducted in patients undergoing HD in the same way as in those not receiving it. Moreover, because the pharmacokinetics of the administered corticosteroid is considered independent of HD, the amount of steroid should not be adjusted by renal function.…”

Section: Discussionmentioning

confidence: 83%

“…Our results are consistent with those of a previous report that demonstrated that patients with ISSHL undergoing HD did not have a worse hearing prognosis. 8 …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“… 4 , 5 By contrast, a previous study demonstrated that HD itself did not affect the hearing prognosis of patients with ISSHL. 8 Therefore, the relationship between ISSHL and HD has not been fully elucidated. Consequently, the effect of global standard treatment, such as systemic steroid therapy for patients undergoing HD, is uncertain.…”

Section: Introductionmentioning

confidence: 99%

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Clinical features and hearing prognosis of idiopathic sudden sensorineural hearing loss in patients undergoing hemodialysis: A retrospective study

Yamamoto

Kurioka

Furuki

et al. 2021

Laryngoscope Investig Oto

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Background: Patients undergoing hemodialysis (HD) tend to experience hearing loss, including idiopathic sudden sensorineural hearing loss (ISSHL). However, little is known about the relationship between HD and ISSHL.Objective: To investigate the effects of HD on the hearing level and the treatment prognosis of ISSHL. Methods: We reviewed the medical records of 23 patients with ISSHL receiving HD treatment (HD group) and 101 patients with ISSHL not receiving HD treatment (non-HD group), and assessed clinical features, results of audiometric tests and blood examination results.Results: Statistically significant differences were not observed in pretreatment hearing level and hearing recovery of the ear affected with ISSHL between the two groups (P > .05). Conversely, hearing thresholds in the unaffected ear were statistically different (P < .0001), and the hearing thresholds of the HD groups were significantly increased compared with those of the non-HD groups, especially at high frequency. In addition, patients with renal dysfunction not receiving HD treatment showed similar hearing thresholds in the unaffected ear when compared with patients receiving HD treatment.Conclusion: HD itself did not influence the treatment prognosis of ISSHL. Renal dysfunction itself, and not HD treatment, worsened the hearing level. As similar treatment results are expected, standard treatment should be administered to patients undergoing HD.

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Section: Discussionmentioning

confidence: 83%

“…Our results are consistent with those of a previous report that demonstrated that patients with ISSHL undergoing HD did not have a worse hearing prognosis. 8 …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical features and hearing prognosis of idiopathic sudden sensorineural hearing loss in patients undergoing hemodialysis: A retrospective study

Yamamoto

Kurioka

Furuki

et al. 2021

Laryngoscope Investig Oto

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“…All SSNHL patients received PTA before the onset of treatment, and they were treated with standard treatment protocol in our department, including oral or intravenous steroids, and adjuvant blood flowing promoting agents as our previous publication described ( Wang et al, 2019 ). PTA was conducted before the first day of treatment onset, and the initial hearing threshold was calculated based on the arithmetic mean of thresholds at 500, 1000, 2000, and 4000 Hz.…”

Section: Methodsmentioning

confidence: 99%

Diagnostic and predictive values of serum metabolic profiles in sudden sensorineural hearing loss patients

Wang

Gao

Jiang

2022

Front. Mol. Biosci.

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Sudden sensorineural hearing loss (SSNHL) is an otologic emergency, and metabolic disturbance is involved in its pathogenesis. This study recruited 20 SSNHL patients and 20 healthy controls (HCs) and collected their serum samples. Serum metabolites were detected by liquid chromatography-mass spectrometry, and metabolic profiles were analyzed. All patients were followed up for 3 months and categorized into recovery and non-recovery groups. The distinctive metabolites were assessed between two groups, and their predictive values for hearing recovery were evaluated. Analysis results revealed that SSNHL patients exhibited significantly characteristic metabolite signatures compared to HCs. The top 10 differential metabolites were further analyzed, and most of them showed potential diagnostic values based on receiver operator characteristic (ROC) curves. Finally, 14 SSNHL patients were divided into the recovery group, and six patients were included in the non-recovery group. Twelve distinctive metabolites were observed between the two groups, and ROC curves demonstrated that N4-acetylcytidine, p-phenylenediamine, sphingosine, glycero-3-phosphocholine, and nonadecanoic acid presented good predictabilities in the hearing recovery. Multivariate analysis results demonstrated that serum N4-Acetylcytidine, sphingosine and nonadecanoic acid levels were associated with hearing recovery in SSNHL patients. Our results identified that SSNHL patients exhibited distinctive serum metabolomics signatures, and several serum biomarkers were proved to be potential in predicting hearing recovery. The discriminative metabolites might contribute to illustrating the mechanisms of SSNHL and provide possible clues for its treatments.

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Treatment outcomes for idiopathic sudden sensorineural hearing loss in dialysis patients

Kim,

Lee,

Kim

et al. 2024

Sci Rep

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Idiopathic sudden sensorineural hearing loss (ISSNHL) is challenging for both nephrologists and otolaryngologists treating patients undergoing dialysis. This single-center, retrospective, observational study investigated the treatment outcomes of patients with ISSNHL undergoing dialysis, enrolling 700 patients (47 undergoing and 653 not undergoing dialysis) diagnosed with ISSNHL between January 2005 and December 2021 at Asan Medical Center, Republic of Korea. To balance pre-existing clinical characteristics, 1:5 propensity score matching (PSM) was performed with the patients who were not undergoing dialysis. Treatment included high-dose systemic steroid therapy or intra-tympanic steroid injections. The pure tone average of the groups was compared before and 2 weeks and 2 months after treatment. The hearing-improvement degree was evaluated using Siegel's criteria. Before PSM, age, prevalence of diabetes or hypertension, initial hearing threshold at each frequency level (0.5, 1, 2, and 4 kHz), and treatment strategies exhibited significant between-group differences. However, in the PS-matched cohort, none of the confounders showed significant between-group differences. Two months after steroid treatment, the non-dialysis patient group demonstrated significantly higher average improvement in pure tone audiometry (P = 0.029) and greater percentage of complete response according to Siegel's criteria. This study suggests that treatment outcomes for ISSNHL are significantly poorer for patients undergoing than for those not undergoing dialysis.

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Sudden sensorineural hearing loss with end-stage renal disease: a report of 32 cases

Cited by 8 publications

References 17 publications

Clinical features and hearing prognosis of idiopathic sudden sensorineural hearing loss in patients undergoing hemodialysis: A retrospective study

Clinical features and hearing prognosis of idiopathic sudden sensorineural hearing loss in patients undergoing hemodialysis: A retrospective study

Diagnostic and predictive values of serum metabolic profiles in sudden sensorineural hearing loss patients

Treatment outcomes for idiopathic sudden sensorineural hearing loss in dialysis patients

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