SUDOSCAN, an effective tool for screening chronic kidney disease in patients with type 2 diabetes

Mao, Fei; Liu, Siying; Qiao, Xuguang; Zheng, Hangping; Xiong, Qian; Wen, Jie; Zhang, Shuo; Zhang, Zhaoyun; Ye, Hongying; Shi, Hongli; Lü, Bin; Li, Yiming

doi:10.3892/etm.2017.4689

Cited by 18 publications

(10 citation statements)

References 35 publications

(53 reference statements)

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“…The primary endpoint was the difference of ESC values, in patients with FM and HVs, on hands and feet measured by Sudoscan, a noninvasive, quantitative, rapid, and reproducible tool that evaluates sweat gland function. 18,19,22,23 This device is based on an electrochemical reaction between steel electrodes and chloride ions. 19 Sudoscan measurements were carried out twice, at T 0 and T 0 + 30 minutes (T 30 ), to ensure reproducibility of the test.…”

Section: Endpointsmentioning

confidence: 99%

“…A‐delta and C nerve fibers, involved in painful and thermal perception, also innervate sweat glands that are linked to the autonomic nervous system, and sweat gland innervation could be dysfunctional because of an alteration of these nerve fibers. Such a dysautonomia may be a detectable abnormality in diabetic SFN, familial amyloid polyneuropathy, or Fabry's disease, and has been studied using an electrophysiological noninvasive tool (Sudoscan; Impeto Medical, Paris, France) that measures electrochemical skin conductance (ESC).…”

Section: Introductionmentioning

confidence: 99%

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Electrochemical Skin Conductance and Quantitative Sensory Testing on Fibromyalgia

et al. 2019

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Background An impairment of the peripheral nervous system has been suggested in fibromyalgia (FM). Noninvasive distal electrochemical skin conductance (ESC) has been studied little so far when combined with quantitative sensory testing (QST) in patients with FM. Methods This study (clinicaltrials.gov NCT03347669) included 50 female patients with FM and 50 matched healthy volunteers (HVs). ESC (measured in microsiemens [µS] with Sudoscan), as well as psychological, quality of life, sleep, and social characteristics, were assessed in both groups. In a subgroup of 24 patients with FM and 24 HVs, QST of cold and warm detection and pain thresholds and diffuse noxious inhibitory controls (DNICs) were explored. Statistical analysis was performed for a 2‐sided type I error at 5%. Results Between patients with FM and HVs, ESC values differed (71.4 ± 11.2 µS vs. 74.4 ± 10.3 µS, respectively; P = 0.003), especially on the dominant hand (P = 0.03), where more patients with FM had ESC values < 66 µS than did HVs (P = 0.046). No difference was observed on feet. In patients with FM, all collected characteristics were impaired (P < 0.001), DNICs were less functional, detection thresholds occurred later, and pain thresholds occurred earlier. No correlation was observed between ESC and DNICs or with any parameter. Conclusion This study shows that the sudomotor function is significantly impaired in patients with FM, especially on the dominant hand. This occurs in parallel with adjustments of detection and pain thresholds in the context of deficient spinal pain modulation. ESC values combined with QST values are relevant in the context of patients with FM and need to be explored further in this nociception‐autonomic system intertwining.

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Section: Endpointsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Electrochemical Skin Conductance and Quantitative Sensory Testing on Fibromyalgia

et al. 2019

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“…Electrochemical skin conductanceMore recently, the Sudoscan was developed. It is a simple, quick, painless, and non-invasive quantitative test measuring C-fiber postganglionic sympathetic nerve function in sweat glands of the palms and soles of the feet, areas that contain a high density of these glands 1,[133][134][135]. The Sudoscan measures the electrochemical skin conductance [135][136][137].…”

mentioning

confidence: 99%

Small‐fiber neuropathy: Expanding the clinical pain universe

Sopacua

Hoeijmakers

Merkies

et al. 2019

J Peripheral Nervous Sys

104

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Small‐fiber neuropathy (SFN) is a disorder of thinly myelinated Aδ and unmyelinated C fibers. SFN is clinically dominated by neuropathic pain and autonomic complaints, leading to a significant reduction in quality of life. According to international criteria, the diagnosis is established by the assessment of intraepidermal nerve fiber density and/or quantitative sensory testing. SFN is mainly associated with autoimmune diseases, sodium channel gene variants, diabetes mellitus, and vitamin B12 deficiencies, although in more than one half of patients no etiology can be identified. Recently, gain‐of‐function variants in the genes encoding for the Nav1.7, Nav1.8 and Nav1.9 sodium channel subunits have been discovered in SFN patients, enlarging the spectrum of underlying conditions. Sodium channel gene variants associated with SFN can lead to a diversity of phenotypes, including different pain distributions and presence or absence of autonomic symptoms. This suggests that SFN is part of a clinical continuum. New assessments might contribute to a better understanding of the cellular and molecular substrates of SFN and might provide improved diagnostic methods and trial designs in the future. Identification of the underlying mechanisms may inform the development of drugs that more effectively address neuropathic pain and autonomic symptoms of SFN.

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“…In a Chinese cohort, Sudoscan™ was a useful method to detect PN in a screening of 394 asymptomatic persons with diabetes [33].…”

Section: Discussionmentioning

confidence: 99%

Feasibility and Effectiveness of Electrochemical Dermal Conductance Measurement for the Screening of Diabetic Neuropathy in Primary Care. Decoding Study (Dermal Electrochemical Conductance in Diabetic Neuropathy)

Vila

Mur

Costa

et al. 2019

JCM

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Diabetes mellitus (DM) is the leading cause of polyneuropathy in the Western world. Diabetic neuropathy (DNP) is the most common complication of diabetes and is of great clinical significance mainly due to the pain and the possibility of ulceration in the lower limbs. Early detection of neuropathy is essential in the medical management of this complication. Early unmyelinated C-fiber dysfunction is one of the typical findings of diabetic neuropathy and the first clinical manifestation of dysfunction indicating sudomotor eccrine gland impairment. In order to assess newly developed technology for the measurement of dermal electrochemical conductance (DEC), we analyzed the feasibility and effectiveness of DEC (quantitative expression of sudomotor reflex) as a screening test of DNP in primary health care centers. The study included 197 people (with type 2 diabetes, prediabetes and normal tolerance) who underwent all the protocol tests and electromyography (EMG). On comparing DEC with EMG as the gold standard, the area under the receiver operating characteristic (ROC) curve (AUC, area under the curve) was 0.58 in the whole sample, AUC = 0.65 in the diabetes population and AUC = 0.72 in prediabetes, being irrelevant in subjects without glucose disturbances (AUC = 0.47). Conclusions: In usual clinical practice, DEC is feasible, with moderate sensitivity but high specificity. It is also easy to use and interpret and requires little training, thereby making it a good screening test in populations with diabetes and prediabetes. It may also be useful in screening general populations at risk of neuropathy.

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SUDOSCAN, an effective tool for screening chronic kidney disease in patients with type 2 diabetes

Cited by 18 publications

References 35 publications

Electrochemical Skin Conductance and Quantitative Sensory Testing on Fibromyalgia

Electrochemical Skin Conductance and Quantitative Sensory Testing on Fibromyalgia

Small‐fiber neuropathy: Expanding the clinical pain universe

Feasibility and Effectiveness of Electrochemical Dermal Conductance Measurement for the Screening of Diabetic Neuropathy in Primary Care. Decoding Study (Dermal Electrochemical Conductance in Diabetic Neuropathy)

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