Sugammadex: clinical development and practical use

Fuchs‐Buder, Thomas; Meistelman, Claude; Raft, Julien

doi:10.4097/kjae.2013.65.6.495

Cited by 66 publications

(61 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This can be observed with several anesthetic agents; therefore its signification was highly questionable. Fuchs-Buder et al have confirmed the lack of cardiovascular effects of both 2 and 4 mg/kg sugammadex in patients with cardiovascular disease undergoing non cardiac surgery [16].…”

Section: Discussionmentioning

confidence: 90%

“…Results: Intracerebroventricular SUG administration did not result in any changes in behavioral status, locomotor activity or posture at any doses (2,4,8,16 and 32 mg/kg). There was no tonic clonic convulsion or seizure development following the sugammadex administration.…”

Section: Introductionmentioning

confidence: 89%

“…Increasing the administered dose is not always a solution because it exhibits ceiling effect greater than 70 µg/kg dose due to limited amount of acetylcholine at the neuromuscular junction. Additionally the recovery of neuromuscular blockage following neostigmine administration is not fast enough [16].…”

Section: Effects Of Intracerebroventricular Sugammadex Administrationmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Intracerebroventricular Sugammadex Administration on Central Nervous System in Rats

Erdost¹,

Öçmen²,

Duru³

et al. 2016

Brain Disord Ther

View full text Add to dashboard Cite

Introduction: Sugammadex (Bridon ®) (SUG) is a recently developed neuromuscular block reversing agent. SUG can reverse also deep neuromuscular blockages in a short time period unlike other existing agents. SUG passes across blood brain barrier (BBB) in a very low ratio in normal patients. However SUG may pass the BBB in a higher ratio in patients whom BBB integrity is decreased. Since SUG passes BBB in a low ratio in normal patients there are only a small amount of studies investigating effects of this agent on central nervous system (CNS). In this study we aimed to assess the effects of SUG administered directly to intracerebroventricular space on CNS system of rats.

show abstract

Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 89%

Section: Effects Of Intracerebroventricular Sugammadex Administrationmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Intracerebroventricular Sugammadex Administration on Central Nervous System in Rats

Erdost¹,

Öçmen²,

Duru³

et al. 2016

Brain Disord Ther

View full text Add to dashboard Cite

show abstract

“…One of the most compelling factors of sugammadex is its ability to reverse -reliably and quickly -deep NMB defined as 0 twitches after a TOF stimulation or 1 to 2 twitches after a tetanic stimulation, PostTetanic Count=1-2 (PTC=1-2) [9,10]. Recently, Rahe-Meyer et al [14] enrolled patients from 10 different institutions in Germany.…”

Section: Deep Neuromuscular Blockade (Post-tetanic Count=1-2)mentioning

confidence: 99%

A Short Update on Sugammadex with a Special Focus on Economic Assessment of its Use in North America

Zaouter¹,

Mion²,

Palomba³

et al. 2017

J Anesth Clin Res

View full text Add to dashboard Cite

Sugammadex offers significant advantages over the current anticholinesterase reversal drugs. Sugammadex used has been approved for the United Stated and for Canada since December 2015 and February 2016, respectively. The present article aims to provide a straightforward and concise review of the most recent literature describing its clinical advantages in routine use. A thorough and cost-effective evaluation has been conducted specifically for North America to determine if its price justifies its inclusion into regular patients' care. The search examined the relevant literature from January 2013 to October 2016. The present narrative review describes how sugammadex could play a crucial role in the modern conduct of anesthesia. The particular emphasis on sugammadex cost-effective analysis performed in this article suggests that this new reversal agent should be considered for a wider use in North America.

show abstract

“…Short to intermediate acting muscle relaxants are used as there may be no need to reverse them. Sugammadex is a novel agent that leads to rapid reversal of non-depolarising agents which may be used to hasten early reversal and extubation [20].…”

Section: General Anaesthesiamentioning

confidence: 99%

Anaesthesia in Fast Track Gastrointestinal Surgeries

Prabhakar¹

2014

J Anesth Clin Res

View full text Add to dashboard Cite

Fast track surgery is a global healthcare package for the care of the patient in the peri-operative period. It consists of a multi-disciplinary team approach where several interventions of surgery, anaesthesia, nursing, nutrition and physical rehabilitation are simultaneously applied to expedite recovery. Other than surgical technique the cornerstone of a successful fast track program is anaesthesia delivery. By using the several interventions at the disposal of an anaesthesiologist there should be a reduction in the surgical stress induced on a patient. Each phase before, during and after surgery is targeted to employ techniques known to facilitate early recovery after surgery. The Anaesthesiologist-Surgeon partnership is crucial in effective peri-operative management of the patient. Understanding each one's role and places where their paths coincide is essential. The healthcare delivery system stands to gain a lot from the effective implementation of a fast track surgery program. Strict adherence to fast track principles has shown to be beneficial but there is scope of flexibility and individualisation. An appropriate fast track policy is one which is suited to meet local requirements and formulated with facilities that are locally available. Even though it has been demonstrated that fast track surgery is safe and effective there has not been across the board acceptance of all its aspects.

show abstract

Sugammadex: clinical development and practical use

Cited by 66 publications

References 37 publications

Effects of Intracerebroventricular Sugammadex Administration on Central Nervous System in Rats

Effects of Intracerebroventricular Sugammadex Administration on Central Nervous System in Rats

A Short Update on Sugammadex with a Special Focus on Economic Assessment of its Use in North America

Anaesthesia in Fast Track Gastrointestinal Surgeries

Contact Info

Product

Resources

About